John-Paul Mutebi

ORCID: 0000-0001-7254-6537
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Mosquito-borne diseases and control
  • Viral Infections and Vectors
  • Malaria Research and Control
  • Dengue and Mosquito Control Research
  • COVID-19 epidemiological studies
  • Vector-borne infectious diseases
  • Insect symbiosis and bacterial influences
  • Vector-Borne Animal Diseases
  • Viral Infections and Outbreaks Research
  • Zoonotic diseases and public health
  • Insect Pest Control Strategies
  • Animal Ecology and Behavior Studies
  • Species Distribution and Climate Change
  • Virology and Viral Diseases
  • Public Health and Environmental Issues
  • Genetic diversity and population structure
  • Insect and Pesticide Research
  • Plant Parasitism and Resistance
  • Insect Resistance and Genetics
  • Botany and Geology in Latin America and Caribbean
  • Herpesvirus Infections and Treatments
  • Animal and Plant Science Education
  • Insects and Parasite Interactions
  • Insect-Plant Interactions and Control
  • International Development and Aid

Miami-Dade Public Library System
2020-2024

Waste Management (United States)
2024

Centers for Disease Control and Prevention
2013-2023

Florida Medical Entomology Laboratory
2020

National Center for Emerging and Zoonotic Infectious Diseases
2019

Vermont Department of Health
2012

MaineHealth
2012

Maine Medical Center
2012

Maine Medical Center Research Institute
2012

Animal and Plant Health Inspection Service
2012

Abstract Aedes (Stegomyia) aegypti (L.) and albopictus (Skuse) transmit arboviruses that are increasing threats to human health in the Americas, particularly dengue, chikungunya, Zika viruses. Epidemics of associated arboviral diseases have been limited South Central America, Mexico, Caribbean Western Hemisphere, with only minor localized outbreaks United States. Nevertheless, accurate up-to-date information for geographical ranges Ae. States is urgently needed guide surveillance enhance...

10.1093/jme/tjw072 article EN Journal of Medical Entomology 2016-06-09

The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most world's tropical belt over past four centuries, after evolution "domestic" form specialized biting humans breeding water storage containers. Here, we show specialization subsequent spread A. out were accompanied by an increase its intrinsic ability acquire transmit emerging pathogen Zika virus. Thus, recent...

10.1126/science.abd3663 article EN Science 2020-11-20

Aedes (Stegomyia) aegypti (L.) and albopictus (Skuse) are potential vectors of Zika, dengue, chikungunya viruses in the United States. A Zika virus outbreak Florida summer 2016, driven by Ae. resulting > 200 locally acquired cases human illness, underscored need for up-to-date information on geographic distribution In early we conducted a survey literature review to compile county records presence States from 1995 2016. Surveillance these was intensified across during fall At end therefore...

10.1093/jme/tjx088 article EN public-domain Journal of Medical Entomology 2017-06-19

Previous studies with a limited number of strains have indicated that there are two genotypes yellow fever (YF) virus in Africa, one west Africa and the other east central Africa. We examined prM/M portion E protein for panel 38 wild YF from representing different countries times isolation. Examination revealed more complex genetic relationship than previously reported. Overall, nucleotide substitutions varied 0 to 25.8% amino acid 9.1%. Phylogenetic analysis using parsimony neighbor-joining...

10.1128/jvi.75.15.6999-7008.2001 article EN Journal of Virology 2001-08-01

Mathematical models have been widely used to study the population dynamics of mosquitoes as well test and validate effectiveness arbovirus outbreak responses mosquito control strategies. The objective this is assess diel activity in Miami-Dade, Florida, Brownsville, Texas, most affected areas during Zika 2016–2017, evaluate simulated adulticide treatments on local populations. To variations patterns, were collected hourly for 96 hours once a month from May through November 2019 Miami-Dade...

10.1371/journal.pntd.0011074 article EN public-domain PLoS neglected tropical diseases 2023-01-26

African populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear what extent true dengue (DENV), most prevalent flavivirus humans. Addressing question complicated substantial genetic diversity among DENV strains, notably in form four types (DENV1 DENV4), that can lead genetically specific...

10.1371/journal.pntd.0011862 article EN cc-by PLoS neglected tropical diseases 2024-03-25

Aboveground and belowground populations of the mosquito Culex pipiens L. are traditionally classified as form molestus, respectively, gene flow between forms is thought to be limited. Relatively few f. molestus have been found in United States, which has hindered their study North America. In this study, we used microsatellites characterize a newly discovered population Chicago, IL, compared levels genetic diversity differentiation aboveground from Chicago New York City, NY. Levels...

10.1603/me10031 article EN Journal of Medical Entomology 2010-08-31

A large number of arthropod-borne viruses are endemic to East Africa. As a part the process undertaking systematic characterization mosquito fauna Uganda, we examined mosquitoes collected from 2008 through early 2012 for known and novel viruses. In all, 8,288 pools containing 157,554 were tested. Twenty-nine isolations 11 different made nine distinct species identified only genus Culex. Identified family Togaviridae, alphaviruses Sindbis Babanki viruses; Rhabdoviridae, hapaviruses Mossuril...

10.1093/jme/tjx120 article EN public-domain Journal of Medical Entomology 2017-06-22

Abstract In 2016, four clusters of local mosquitoborne Zika virus transmission were identified in Miami-Dade County, Florida, USA, generating “red zones” (areas into which pregnant women advised against traveling). The County Mosquito Control Division initiated intensive control activities, including property inspections, community education, and handheld sprayer applications larvicides adulticides. For the first time, used a combination areawide ultralow-volume adulticide low-volume...

10.3201/eid2605.191606 article EN cc-by Emerging infectious diseases 2020-04-20

Abstract Aedes aegypti is the main vector of arboviral diseases such as dengue, chikungunya and Zika. A key feature for disease transmission modeling control planning adult mosquito dispersal. We studied Ae dispersal by conducting a mark-capture study naturally occurring Ae. from discarded containers found along canal that divided two residential communities in Donna, Texas, USA. Stable isotopes were used to enrich with either 13 C or 15 N. Adult mosquitoes collected outdoors yards...

10.1038/s41598-020-63670-9 article EN cc-by Scientific Reports 2020-04-22

Powassan virus and its subtype, deer tick virus, are closely related tick-borne flaviviruses that circulate in North America. The incidence of human infection by these agents appears to have increased recent years. To define exposure patterns among white-tailed deer, potentially useful sentinels frequently parasitized ticks, we screened serum samples collected during 1979-2010 Connecticut, Maine, Vermont for neutralizing antibody using a novel recombinant virus-West Nile chimeric virus....

10.4269/ajtmh.12-0586 article EN American Journal of Tropical Medicine and Hygiene 2013-04-09

Abstract The diel biting activity of Aedes ( Stegomyia ) aegypti (L) populations was extensively investigated in the early 1900s to gain more information on biology Ae. , and this used devise effective approaches controlling species protect human population from widespread arbovirus outbreaks. However, few contemporary studies are available regarding patterns . To assess southern Florida Texas, we conducted 96-h uninterrupted mosquito collections once each month May through November 2019...

10.1038/s41598-022-06586-w article EN cc-by Scientific Reports 2022-03-29

Genetic relationships among flaviviruses within the yellow fever (YF) virus genetic group were investigated by comparing nucleotide sequences of 3' noncoding region (3'NCR). Size heterogeneity was observed between members and even strains same viral species. variation YF due to duplications and/or deletions repeated sequence elements (RYF). West African genotypes had three copies RYF (RYF1, RYF2, RYF3); Angola East Central two (RYF1 South American only a single copy (RYF3). Nucleotide...

10.1128/jvi.78.18.9652-9665.2004 article EN Journal of Virology 2004-08-26

ABSTRACT The 3′ noncoding region (3′ NCR) of flaviviruses contains secondary and tertiary structures essential for virus replication. Previous studies yellow fever (YFV) dengue have found that modifications to the NCR are sometimes associated with attenuation in vertebrate and/or mosquito hosts. NCRs 117 isolates South American YFV been examined, major deletions duplications conserved RNA identified several wild-type isolates. Nineteen (designated YF-XL isolates) from Brazil, Trinidad,...

10.1128/jvi.79.6.3807-3821.2005 article EN Journal of Virology 2005-02-24

Emerging infectious disease events are frequently caused by arthropod-borne viruses (arboviruses) that maintained in a zoonotic cycle between arthropod vectors and vertebrate wildlife species, with spillover to humans areas where human populations interface. The greater Congo basin region, including Uganda, has historically been hot spot for emergence of known novel arboviruses. Surveillance is critical activity monitoring predicting outbreaks arboviral disease, identification blood meals...

10.7589/2012-08-213 article EN Journal of Wildlife Diseases 2013-06-18

Eastern equine encephalitis (EEE) is one of the most severe arboviral encephalitides in North America. Before 2009, limited nonhuman EEE virus activity had been reported Maine, all from southernmost area state. No human case has a Maine resident.We review to Centers for Disease Control 2009 and describe current testing practices possible cases.In fatal cases were identified 15 horses, 1 llama, 3 flocks pheasants with extending into central part Although no identified, diagnostic meningitis...

10.1089/vbz.2010.0189 article EN Vector-Borne and Zoonotic Diseases 2011-01-23

The mosquito fauna in many areas of western Uganda has never been studied and is currently unknown. One area, Bwamba County, previously documented but the species lists have not updated for >40 yr. This paucity data makes it difficult to determine which arthropod-borne viruses pose a risk human or animal populations. Using CO2 baited-light traps, from 2008 through 2010, 67,731 mosquitoes were captured at five locations including Mweya, Sempaya, Maramagambo, Bwindi (BINP), Kibale (KNP)....

10.1603/me12111 article EN cc-by-nc Journal of Medical Entomology 2012-11-01

Entomologic investigations were conducted during an intense outbreak of West Nile virus (WNV) disease in Maricopa County, Arizona July 31-August 9, 2010. The compared the East Valley area, and a demographically similar control area northwestern metropolitan Phoenix where no human cases reported. Five mosquito species identified each composition was both areas. Significantly more Culex quinquefasciatus females collected by gravid traps at Outbreak sites (22.2 per trap night) than (8.9 night),...

10.4269/ajtmh.2012.11-0700 article EN American Journal of Tropical Medicine and Hygiene 2012-10-30

From July to September, 2009, an outbreak of eastern equine encephalitis virus (EEEv) occurred in five counties Maine. The was isolated from 15 horses, 1 llama, and pheasants three separate captive flocks. One wild turkey, screened before translocation, also showed exposure the January 2010. Two pools Culiseta melanura (Coquillett) tested positive for EEEv during routine seasonal surveillance York County but none mosquitoes collected rapid response surveys positive. There were more Cs. July,...

10.4269/ajtmh.2012.11-0358 article EN American Journal of Tropical Medicine and Hygiene 2012-12-04

Aedes (Stegomyia) aegypti (L.) and Ae. albopictus (Skuse) mosquitoes can transmit dengue, chikungunya, yellow fever, Zika viruses. Limited surveillance has led to uncertainty regarding the geographic ranges of these vectors globally, particularly in regions at present-day margins habitat suitability such as contiguous United States. Empirical models based on environmental conditions augment gaps describe estimated potential species ranges, but model accuracy is unclear. We identified...

10.1371/journal.pcbi.1007369 article EN public-domain PLoS Computational Biology 2019-10-10

A population of Culex pipiens form molestus was detected in a drainage sump Calumet Water Reclamation Plant on the South Side Chicago, IL. This is first documented collection within city Chicago and second metropolitan area >60 years. Field-collected specimens were used to initiate colony without bloodfeeding, autogenous stenogamous.

10.2987/09-5910.1 article EN Journal of the American Mosquito Control Association 2009-12-01
Coming Soon ...