A5101510903- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Full-Duplex Wireless Communications
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- SARS-CoV-2 and COVID-19 Research
- Genital Health and Disease
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Oral health in cancer treatment
- HIV/AIDS drug development and treatment
- Reproductive tract infections research
- Antenna Design and Analysis
- Vector-Borne Animal Diseases
- Histiocytic Disorders and Treatments
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Mycobacterium research and diagnosis
University of Belgrade
2013-2023
Czech Academy of Sciences, Institute of Microbiology
1990-2023
Institut za Reumatologiju
2006-2009
St Mary's Hospital
2008
Chinese Academy of Medical Sciences & Peking Union Medical College
2008
University of Ulster
2008
Altnagelvin Area Hospital
2008
Selçuk University
2008
Epstein-Barr virus (EBV) infection is a significant factor in the pathogenesis of nasopharyngeal carcinoma, especially undifferentiated carcinoma type (UCNT, World Health Organization III), which dominant histopathological high-risk areas. The major EBV oncogene latent membrane protein 1 (LMP1). LMP1 gene shows variability with different tumorigenic and immunogenic potentials. nuclear antigen (EBNA1) regulates progression EBV-related tumors; however, influence EBNA1 sequence on tumor...
Background: Oral reactivation of latent Herpes simplex virus (HSV) infection may easily occur in cancer patients. Virus can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. Methods: Polymerase chain reaction (PCR), cell‐culture direct immunofluorescence have been used to determine the frequency HSV 60 patients undergoing chemotherapy for different...
The objective of this case-control study was to test the existing hypotheses about factors related occurrence hepatocellular carcinoma in population Belgrade (Serbia).The investigation conducted between 2004 and 2007 consisted 45 newly diagnosed, histologically confirmed patients 90 individually gender- age-matched hospital controls. Conditional univariate multivariate logistic regression analyses were applied.A highly statistically significant association (P = 0.001) demonstrated HBsAg...
To investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] bone resorption regulators [receptor activator nuclear factor (NF-κB) ligand (RANKL) osteoprotegerin (OPG)] compared to EBV-negative periapical healthy pulp tissues.The experimental group consisted 30 EBV-positive collected in conjunction with apicoectomy. The tissues 20 impacted third...
Objectives This study aimed to analyse Epstein–Barr virus ( EBV ) and human cytomegalovirus HCMV viral loads in symptomatic asymptomatic apical periodontitis lesions, determine levels of TNF ‐α, IL ‐1β ‐6 these lesions investigate a possible correlation between herpesviral copy numbers proinflammatory cytokines. Materials Methods A total 100 samples were subjected analysis by nested polymerase chain reaction PCR TaqMan real‐time . The concentrations determined ELISA method. SPSS software was...
Abstract Disseminated neonatal herpes simplex virus (HSV) infection is characterized by progressive multiple organ failure and high mortality rates. It can result from with either HSV-1 or HSV-2. We report a case of disseminated that was caused
Introduction: Recent studies suggest that some viruses, including human cytomegalovirus (CMV), may be involved in the pathogenesis of periapical lesions. Since cysts (PCs) represent next stage evolution granuloma, it seemed reasonable to investigate presence CMV PCs and any possible relationship between its clinical features those cysts, as well compare results obtained with corresponding findings non‐inflammatory lesions, like odontogenic keratocysts (OKCs). Methods: Samples 33 10 OKCs, at...
Abstract Understanding the prevalence and diversity of HBsAg variants in a population is fundamental to assay design planning vaccination programs. It has been shown that mutations within S gene, caused by selection or natural variation, can lead false‐negative results assays for HBsAg, have clinical implications, such as evading anti‐HBV immunoglobulin therapy vaccine‐induced immunity. The region where most these occur known major hydrophilic (MHR). aim this study was determine mutational...
Abstract Seven strains of Epstein–Barr virus (EBV) are defined based on C‐terminal sequence variations the latent membrane protein 1 (LMP1). Some strains, especially those with a 30‐bp deletion, thought to be related tumorigenic activity and geographical localization. The aims study were determine prevalence different LMP1 investigate variation in region Serbian isolates. This included 53 EBV‐DNA‐positive plasma tissue block samples from patients mononucleosis syndrome, renal...
To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external internal implant surfaces between participants with peri-implantitis healthy peri-implant tissues to quantitatively assess relation EBV periopathogens inside microbiologic associated peri-implantitis.Microbiologic specimens were retrieved from 84 patients wearing 190 implants estimate levels 10 in pocket internal-implant connection using polymerase chain reaction.The study sample consisted 113 77...
Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator nuclear factor kappa-β ligand (RANKL) osteoprotegerin (OPG)), proinflammatory cytokines (tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) IL-6) compared EBV negative lesions. Additionally, the potential correlation between investigated in was...
A National Immunization Technical Advisory Group (NITAG) is a multi-disciplinary body of national experts that provide evidence-based recommendations to policy-makers assist them in making informed immunization policy and programme decisions. During the COVID-19 pandemic, NITAGs faced many challenges for vaccines due rapidly evolving situation with new vaccine products available short time period limited data on effectiveness. The authors reviewed process used by Serbia's NITAG, which called...
To gain insight concerning the genetic diversity of HIV-1 viruses associated with epidemic in Yugoslavia, 45 specimens from HIV-1-infected individuals were classified into subtypes by sequence-based phylogenetic analysis polymerase (pol) region viral genome. Forty-one (91.2%) identified as pol subtype B, 2 C (4.4%), 1 CRF01_AE (2.2%), and CRF02_AG recombinant (2.2%). Nucleotide divergence among B sequences was 4.8%. Results this study show that patients Yugoslavia predominates (91.5%),...
Abstract Persistent infection with one or more highly oncogenic human papillomaviruses (HPVs) high-risk-HPV (HR-HPV) is necessary but not a sufficient aetiological agent for the development of cervical neoplasia. A number viral, host, environmental and behavioural factors are suggested to be associated progression disorder. This study aimed evaluate impact cofactors on disorders in HR-HPV-infected women Serbia. total 541 have been tested by PCR presence HPV cervix. genotypes were determined...
Abstract Background Although cytomegalovirus (CMV) is not considered tumorigenic, there evidence for its oncomodulatory effects and association with hematological neoplasms. Conversely, a number of experimental clinical studies suggest putative anti-tumour effect. We investigated the potential connection between chronic CMV infection in patients B-lymphocyte (B-cell) malignancies retrospective single-center study extracted relevant data on prevalences incidences B-cell cancers world over....
The potential problems of DNA extraction from formalin‐fixed paraffin‐embedded (FFPE) tissue samples and amplification efficiency Human papilloma virus (HPV) may occur in the molecular studies head neck squamous carcinoma (HNSCC). aim this study was to compare HPV detection rate FFPE tissues oral, oropharyngeal, hypopharyngeal, laryngeal cancers using two silica‐based kits three methods. A total 50 specimens HNSCC were analyzed. quality quantity extracted tested by spectrophotometry....
Abstract Certain factors lead to increased reactivation of JC virus (JCV) and immunodeficiency seems be the most important. JCV isolates can classified into eight different genotypes several subtypes based on nucleotide difference in VP1 gene. are strongly associated with particular ethnic groups frequently used as genetic markers for human evolution migration. The aim this study was determine frequency urinary shedding genotype distribution Serbia among patients infected HIV healthy donors....