A5077197176- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Vitamin C and Antioxidants Research
- Ovarian function and disorders
- Cardiovascular Function and Risk Factors
- Coenzyme Q10 studies and effects
- Biomarkers in Disease Mechanisms
- Nephrotoxicity and Medicinal Plants
- Ovarian cancer diagnosis and treatment
- Renal cell carcinoma treatment
- Sulfur Compounds in Biology
- Iron Metabolism and Disorders
- Climate Change and Health Impacts
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Antioxidant Activity and Oxidative Stress
- Metabolism and Genetic Disorders
- Hydrogen's biological and therapeutic effects
- Cardiovascular and exercise physiology
- Child Nutrition and Feeding Issues
- Mitochondrial Function and Pathology
- Heart Failure Treatment and Management
- Selenium in Biological Systems
University of Belgrade
2016-2025
Institut za Reumatologiju
2014-2022
American Journal Experts (United States)
2017
American Society for Clinical Pathology
2017
Centre of Research Excellence in Nutrition and Metabolism
2017
University of Belgrade – Faculty of Medicine
2011
Deleted Institution
2010
University Hospital Medical Center Bezanijska kosa
2007
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% patients surviving >5 years. Asymptomatic in its initial stages, PDAC mostly diagnosed late, when already a locally advanced or metastatic disease, as there are no useful biomarkers for detection early surgery can be curative. We have previously described promising biomarker panel (LYVE1, REG1A, and TFF1) earlier urine. Here, we aimed to establish accuracy an improved panel, including REG1B...
Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification xenobiotics and protection damage. We hypothesized that genetic polymorphism antioxidant enzymes GSTA1, GSTM1, GSTP1 GSTT1 more frequent ESRD modulates degree these patients.GSTA1, genotypes were determined 199 patients age- gender-matched controls. Markers protein lipid damage [thiol groups, carbonyl advanced products, nitrotyrosine, malondialdehyde...
To get more insight into molecular mechanisms underlying oxidative stress and its link with insulin resistance, parameters, as well as, antioxidant enzyme activities were studied in young, non-obese women polycystic ovary syndrome (PCOS). Study was performed 34 PCOS 23 age body mass index (BMI)-matched healthy controls. Plasma nitrotyrosine malondialdehyde (MDA), representative byproducts of protein lipid damage, determined by immunoassay. Antioxidant activities, superoxide dismutase (SOD)...
Understanding the sequelae of COVID-19 is utmost importance. Neuroinflammation and disturbed redox homeostasis are suggested as prevailing underlying mechanisms in neurological propagation long-COVID. We aimed to investigate whether variations antioxidant genetic profile might be associated with Neurological examination (SOD2, GPXs GSTs) determination, well as, genotype analysis Nrf2 ACE2, were conducted on 167 patients. Polymorphisms determined by appropriate PCR methods. Only polymorphisms...
Based on the close relationship between dysregulation of redox homeostasis and immune response in SARS-CoV-2 infection, we proposed a possible modifying role ACE2 glutathione transferase omega (GSTO) polymorphisms individual propensity towards development clinical manifestations COVID-19. The distribution (rs4646116), GSTO1 (rs4925) GSTO2 (rs156697) were assessed 255 COVID-19 patients 236 matched healthy individuals, emphasizing their haplotype effects disease severity. Polymorphisms...
The oxidative stress response via Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) interlinks inflammation- and metabolism-related pathways in chronic kidney disease. We assessed the association between polymorphisms Nrf2, superoxide dismutase (SOD2), glutathione peroxidase (GPX1), risk of end-stage renal disease (ESRD). modifying effect these on both phenotype ESRD prognosis, independently and/or combination with S-transferase M1 (GSTM1) deletion polymorphism, was further analyzed....
Although the original data on systemic oxidative stress in COVID-19 patients have recently started to emerge, we are still far from a complete profile of changes patients’ redox homeostasis. We aimed assess extent damage proteins, lipids and DNA during course acute disease, as well their association with CT pulmonary patterns. In order obtain more insight into origin stress, observed parameters were correlated inflammatory biomarkers multiorgan impairment. this prospective study, included 58...
Objective We investigated the role of glutathione S-transferase A1, M1, P1 and T1 gene polymorphisms potential effect modification by occupational exposure to different chemicals in Serbian bladder cancer male patients. Patients Methods A hospital-based case-control study men comprised 143 histologically confirmed cases 114 age-matched controls. Deletion polymorphism M1 was identified polymerase chain reaction method. Single nucleotide A1 restriction fragment length As a measure size, odds...
To investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] bone resorption regulators [receptor activator nuclear factor (NF-κB) ligand (RANKL) osteoprotegerin (OPG)] compared to EBV-negative periapical healthy pulp tissues.The experimental group consisted 30 EBV-positive collected in conjunction with apicoectomy. The tissues 20 impacted third...
Background: Autism spectrum disorders (ASD) are complex psychiatric disorders, with gene environment interaction being in the basis of their etiology. The association perinatal complications and ASD is well established. Recent findings suggested that oxidative stress polymorphism genes encoding antioxidant enzymes might be involved development ASD. Glutathione transferases (GSTs) have an important role defense system. We aimed to establish whether predictive effects prenatal (as possible...
Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation glutathione transferase P1 (GSTP1). Taking into consideration involvement oxidative stress PC pathogenesis recent advances scientific understanding role GSTP1*Ala114Val rs1138272 polymorphism carcinogenesis, we hypothesized that this single-nucleotide (SNP) influences risk independently of, or combination with, other GST polymorphisms, including...
Objectives: Due to the role of oxidative stress in pathophysiology COVID-19, it is biologically plausible that inter-individual differences patients' clinical manifestations might be affected by antioxidant genetic profile. The aim our study was assess distribution polymorphisms Nrf2 rs6721961, SOD2 rs4880, GPX1 rs1050450, GPX3 rs8177412, and GSTP1 (rs1695 rs1138272) haplotype COVID-19 patients controls, with special emphasis on their association laboratory biochemical parameters.Methods:...
: Despite improvements in screening programs, a large number of patients with colorectal cancer (CRC) are diagnosed an advanced disease stage. Previous investigations imply that glutathione transferases (GSTs) might be associated the development and progression CRC. Moreover, detoxification mechanism oxaliplatin, which represents first line treatment for CRC, is mediated via certain GSTs. The aim this study was to evaluate significance