A5030848835- Bone Metabolism and Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Glycation End Products research
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Protein Hydrolysis and Bioactive Peptides
- Magnesium in Health and Disease
- Proteins in Food Systems
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Polysaccharides and Plant Cell Walls
- Biochemical effects in animals
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Mass Spectrometry Techniques and Applications
- Polysaccharides Composition and Applications
- Enzyme Production and Characterization
- Synthetic Organic Chemistry Methods
- Osteoarthritis Treatment and Mechanisms
- Cultural Differences and Values
- Protease and Inhibitor Mechanisms
- Meat and Animal Product Quality
Keio University
2015-2024
keiyu Hospital
2021-2024
Ono Pharmaceutical (Japan)
2010-2021
Keio University Hospital
2021
Japan Community Healthcare Organization
2021
Osaka Hospital
2021
Disco (japan)
2011-2018
Ono Pharmaceutical (United Kingdom)
2012-2015
Kobe University
1990-2014
Osaka Medical Center for Cancer and Cardiovascular Diseases
2014
A specific assay of 3-deoxyglucosone (3-DG) was developed in our laboratory to help elucidate the relationship between advanced Maillard reaction and diabetic complications. 3-DG is known as a highly reactive intermediate vitro precursor glycosylation end products such pyrraline pentosidine, which have been previously detected vivo. converted stable compound, 2-(2,3,4-trihydroxybutyl)-benzo[g]quinoxaline, by reacting with 2,3-diaminonaphthalene. Since derivative had characteristic UV...
It has been hypothesized that advanced Maillard reaction in vivo could explain some of the age- and diabetes-related changes. Furthermore, involvement with Alzheimer's disease also suggested, as glycation end products, such pyrraline pentosidine, were demonstrated to localize lesions disease. Although aminoguanidine studied extensively established an inhibitor reaction, other candidates have not investigated thoroughly. In present study, we examined inhibitory effect tenilsetam[...
ABSTRACT The purpose of this study is to reanalyze Torrance's longitudinal (1981) by employing a multiple regression analysis find the best predictors for adult creative achievement. A total 211 cases were available study. results led predictive rule that comprised following predictors: creativity test score, childhood future career image, intelligence and existence mentor. These four explained 49% variance in
Sixty‐four Japanese mothers of 3‐ to 6‐year‐olds were interviewed concerning their conceptions children's areas personal control. Mothers granted children choices regarding recreational activities, clothes, and friends foster autonomy competence, but they set limits around daily routines, interpersonal confrontation based on moral, conventional, prudential concerns. believed in reaffirming boundaries when failed follow through with initial decisions. experienced conflict routines activities...
CHARGE syndrome is a congenital disorder caused by mutation of the chromodomain helicase DNA binding protein 7 (CHD7) gene and characterized multiple anomalies including ocular coloboma, heart defects, choanal atresia, retarded growth development, genital and/or urological abnormalities, ear anomalies, hearing loss. In present study, 76% subjects had some type endocrine disorder: short stature (72%), hypogonadotropic hypogonadism (60%), hypothyroidism (16%), combined hypopituitarism (8%). A...
Objectives: The purpose of this study was to determine the validity and reliability a Japanese version Khalfa hyperacusis questionnaire (KHQ) proposed threshold KHQ score for classifying hyperacusis.Methods: In total, 112 patients with (group A) 103 without B). in group A were further classified into following subgroups: subjects as their chief complaint (n = 26, A1) accompanied by complaints tinnitus and/or hearing loss 86, A2).Results: average total 11.8 ± 9.7, which statistically...
Previous studies suggested that the interaction between proteins modified by advanced glycation end products (AGEs) and cells, such as macrophages, may be involved in diabetic angiopathy. Pyrraline is one of AGEs known to elevated plasma rats humans, present vascular lesions elderly subjects. We examined whether modification albumin pyrraline influences its degradation macrophage-like cell line, P388D1 cells. Degradation pyrraline-modified these cells was diminished, causing accumulation The...
Etelcalcetide hydrochloride (Parsabiv®, ONO-5163/AMG 416) is an allosteric modulator of the calcium (Ca)-sensing receptor that was originally produced by KAI Pharmaceuticals Inc. (now Amgen Inc.). It has recently been approved as first intravenous calcimimetic agent for secondary hyperparathyroidism (SHPT) in many countries. injectable drug can be administered and eliminated through dialysis circuit chronic kidney disease patients. In present study, we evaluated vitro pharmacological profile...
Here, we report for the first time quinol peroxidase (QPO), an enzyme that uses ubiquinol‐1 as electron donor reduction of H 2 O to water. We purified QPO > 90% purity from membrane fraction Actinobacillus actinomycetemcomitans . is a 53.6‐kDa protein contains three heme c molecules. The qpo gene was predicted encode putative bacterial cytochrome with N‐terminal extensions containing additional potential ‐binding motif. Although has high sequence homology peroxidases, did not catalyze...
Abstract Ninety‐five Japanese children (aged 6–12) were interviewed using hypothetical stories to examine their reasoning about parent–child conflicts. Participants most likely reject parental authority and support child's discretion in conflict situations where the parent interfered personal choice gave child commands that violated moral conventional principles. However, participants accept when wish conflicted with parent's concern. Participants’ was more varied went against demand....
Abstract Objectives X-linked hypophosphatemic rickets (XLH) is a congenital fibroblast growth factor (FGF)23-related metabolic bone disease that treated with active vitamin D and phosphate as conventional therapies. Complications of these therapies include nephrocalcinosis (NC) caused by excessive urine calcium concentrations. Recently, an anti-FGF23 antibody, burosumab, was developed reported to be effective in poorly-controlled or severe XLH patients. This study aimed reveal the impact...
We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) female cynomolgus monkeys. CIA was induced immunizing bovine type II collagen. ONO-5334 (30 mg/kg/day) orally once daily and MTX (10 mg/body/day) twice weekly for 9 weeks. X-ray (evaluation of destruction) swelling (inflammatory) scores proximal interphalangeal (PIP), distal (DIP),...
Mitochondrial diabetes is characterized by and hearing loss in maternal transmission with a heteroplasmic A3243G mutation the mitochondrial gene. In patients mutation, it has been reported that hepatic involvement rarely observed. We demonstrated case of hypertrophic cardiomyopathy failure diabetes. To clarify pathogenesis we analyzed ultrastructure myocytes, reactive oxygen species (ROS) production liver status heteroplasmy organs involved. cardiomyocytes skeletal muscle, electron...