A5085938672- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- Effects and risks of endocrine disrupting chemicals
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genomics and Rare Diseases
- Systemic Lupus Erythematosus Research
- Eicosanoids and Hypertension Pharmacology
- Heat shock proteins research
- Hormonal Regulation and Hypertension
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Health and Biochemistry
- Carcinogens and Genotoxicity Assessment
- Analytical chemistry methods development
- Alcohol Consumption and Health Effects
- Pharmacology and Obesity Treatment
- DNA and Nucleic Acid Chemistry
- T-cell and B-cell Immunology
- Advanced Chemical Sensor Technologies
- Nerve injury and regeneration
- Connexins and lens biology
- Mitochondrial Function and Pathology
- Diet and metabolism studies
University of Palermo
1996-2016
Mario Negri Institute for Pharmacological Research
2000
The effects of ethyl alcohol and wine (red white) on haemostatic parameters experimental thrombosis were studied in rats; NO was evaluated as a possible mediator these effects. We found that red (12% alcohol) supplementation (8.4±0.4 ml d −1 drinking water, for 10 days) induced marked prolongation ‘template’ bleeding time (BT) (258±13 vs 132±13 s controls; P <0.001), decrease platelet adhesion to fibrillar collagen (11.6±1.0 32.2±1.3%; <0.01) reduction thrombus weight (1.45±0.33...
Benzothiazoles are a part of the molecular structure large number natural products, biocides, drugs, food flavors, and industrial chemicals. They also appear in environment mainly as result their production use rubber vulcanization accelerators. A new headspace solid-phase microextraction (HS-SPME) method for analysis benzothiazole (BTH) wine is described. This fast, inexpensive, does not require solvents. The detection limit BTH was 45 ppt with linearity up to 100 ppb. quantification...
A bstract : We have previously reported that gap junction‐mediated intercellular communication (GJIC) can be restored in junctionally deficient human prostate epithelial cells, also suggesting GJIC activity is regulated by estrogen. In the present work, we report studies on sex steroid regulation of and proliferative both nontumoral (Chang liver, CL) malignant (HepG2, Huh7) liver cells. Junctional cell growth were measured using scrape‐loading/dye‐transfer (SL/DT) MTS assay, respectively....
Abstract: In this work, we have investigated the effects of nutritional antioxidants as antidegenerative agents on glutamate‐induced apoptosis in primary cultures cerebellar granule neurons (CGNs). Glutamate‐induced is also associated with intracellular [Ca 2+ ] i overload, generation reactive oxygen species (ROS), depression cell energy metabolism, cytochrome c release, and increase caspase‐3 activity. Pretreatment (3 h) red wine extract (5 μg/mL) ascorbic acid (30 μM) blocks CGNs. vivo...
The isodecyl neopentanoate is an ingredient used in the cosmetic industry to prepare a nipple fissure balm. We report on 12 newborns that showed elevated C5-acylcarnitine levels upon newborn screening following treatment with first 3 neonates were immediately recalled for confirmatory tests and resulted negative both isovaleric acidemia short/branched chain acyl-CoA dehydrogenase deficiency. In other 9 cases, immediate recall was avoided by applying new second-tier test able confirm presence...