A5013599117- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Multiple and Secondary Primary Cancers
- Global Cancer Incidence and Screening
- Mitochondrial Function and Pathology
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Antioxidant Activity and Oxidative Stress
- Pharmacogenetics and Drug Metabolism
- Gastric Cancer Management and Outcomes
- Hepatitis C virus research
- Parkinson's Disease Mechanisms and Treatments
- HER2/EGFR in Cancer Research
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Phytoestrogen effects and research
- Advanced Breast Cancer Therapies
- Connexins and lens biology
- Toxoplasma gondii Research Studies
- Cell death mechanisms and regulation
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2023-2025
University of Palermo
1996-2024
University of Geneva
2020
Mario Negri Sud Foundation
2000
Mario Negri Institute for Pharmacological Research
2000
University of Genoa
1995
This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes burden rare cancers in Italy. Estimated number new cancer cases yearly diagnosed (incidence), proportion patients alive after diagnosis (survival), and estimated people still a (prevalence) are provided for about 200 different entities.Data herein presented were AIRTUM population- registries (CRs), covering nowadays 52% population. monograph uses database (January 2015), which...
Background: The increasing incidence, rapidly evolving classification, rarity and heterogeneity of neuroendocrine neoplasms (NENs) pose challenges to NEN registration including difficulty in distinguishing carcinoma (NEC) tumours (NETs). Thus, Italy a higher NEC incidence was reported. Focusing on gastroenteropancreatic (GEP) NEN, we aimed review GEP particular cases carcinoma, not otherwise specified (NOS) estimate the NET GEP. Methods We launched pilot study examining carcinomas NOS...
The Diet and Androgen-5 (DIANA-5) trial aimed at testing whether a dietary change based on the Mediterranean diet macrobiotic principles can reduce incidence of breast cancer (BC)-related events. We analyzed adherence to DIANA-5 recommendations by randomization group after 1 year intervention. evaluated association between changes in body weight metabolic syndrome (MS) parameters. BC women aged 35-70 years were eligible. After baseline examinations, randomized into an intervention (IG) or...
Abstract Primary cultures of cerebellar granule neurons (CGNs) were prepared from 8‐day‐old Wistar rats, and maintained in an appropriate medium containing a high (25 mM) concentration KCl. To induce apoptosis, culture was replaced with serum‐free (containing 5 mM KCl) 8 days after plating. Apoptosis measured by the terminal deoxynucleotidyl transferase‐mediated dUTP‐fluorescein nick end‐labeling (TUNEL) method, flow cytometry. Since there is evidence that increased formation reactive oxygen...
Abstract Purpose: The DIANA-5 randomized controlled trial assessed the effectiveness of a diet based on Mediterranean and macrobiotic traditions (macro-Mediterranean diet) in reducing breast cancer recurrence. Patients Methods: study involved 1,542 patients with at high risk recurrence because estrogen receptor–negative cancer, or metabolic syndrome, plasma levels insulin testosterone. Women were randomly assigned to an active dietary intervention (IG) control group (CG). Both groups...
Abstract In this study, primary cultures of cerebellar granule neurons were prepared from eight‐day‐old Wistar rats, and maintained in an appropriate medium containing a high (25 mM) concentration KCl. All experiments performed with fully differentiated (eight days). To induce apoptosis, culture was replaced serum‐free (containing 5 mM KCl) eight days after plating. another series experiments, apoptosis induced by application glutamate (50 μM) to the cell cultures. Apoptosis measured flow...
The presence of androgen receptors on synovial macrophages in human normal and rheumatoid tissues has been described previously. It is now reported that primary cultured obtained from synovia express functional receptors. We have investigated the capacity to metabolize androgens found these cells were capable metabolizing testosterone bioactive metabolite dihydrotestosterone. Therefore, contain key enzymes steroidogenesis, particular 5α‐treductase. Furthermore, interleukin‐1β production by...
Women with deleterious mutations in BRCA genes are at increased risk of breast cancer. However, the penetrance genetic trait may be regulated through environmental factors. This multinational case-only study tested interaction between oral contraceptive use and susceptibility occurrence cancer.We recruited 3,123 patients diagnosed cancer before age 45 years. Participants were classified according to their probability carrying a mutation on basis family history ovarian According approach,...
The aim of this study is to describe the frequency and trend pregnancy-associated cancer (PAC) in Italy, an increasingly relevant phenomenon due postponing age at childbirth. To purpose, a population-based retrospective longitudinal design based on cohorts women aged 15-49 diagnosed with concomitant pregnancy proposed. uses 19 Cancer Registries, covering about 22% linked individual level Hospital Discharge Records. A total 2,861,437 pregnancies 3559 PAC are identified from 74,165 cohort rate...
Background: The incidence of melanoma has steadily increased worldwide and shows geographical variability according to latitude. aim this study was describe the cutaneous malignant (CMM) cases in Province Palermo during period 2003-2005. Methods: 231 incident CMM, registered by Cancer Registry Palermo, were analysed. Anatomic localization, histological type, thickness, ulceration, margins, any lymph node involvement metastases evaluated. A statistical analysis survival rates performed....
The development of new therapeutic strategies, such as monoclonal antibodies directed against human epidermal growth factor receptor-2 (HER2), has offered hopes for women with early breast cancer whose tumors overexpress HER2. We retrospectively analyzed the population-based data Breast Cancer Registry Palermo in 2004-2006, and selected 1401 invasive cases, nonmetastatic at diagnosis, having HER2/neu oncogene expression determined. have correlated this information to age, tumor stage...
A new classification based on gene expression profiling or immunohistochemical (IHC) characteristics may replace current histopathological classifications and predict better clinical outcomes. We used IHC markers to classify incident cases ascertained by the Palermo Breast Cancer Registry (2002-2004) into four subtypes: luminal-A (ER+ PgR+ HER2/neu-); luminal-B PgR+, HER2/neu+); basal-like (ER-, PgR-, HER2+/ER- (HER2/neu+, ER-, PgR-). evaluated HER2/neu, ER PgR in 1300/1985 (65%) cases. The...
In this randomized dietary intervention study (DI) we analyzed levels of androgens, phytoestrogens, and estrogens in 12‐h urine samples 69 healthy postmenopausal women, 37 whom followed a traditional Mediterranean diet for 6 months (intervention group) as compared to 32 women who their regular (control group). Circulating both insulin testosterone (T) were also assayed. Overall, enterolactone (ENL) was the most prominent phytoestrogen urines control its increased by 20% after DI. At baseline...
Abstract: In this work, we have investigated the effects of nutritional antioxidants as antidegenerative agents on glutamate‐induced apoptosis in primary cultures cerebellar granule neurons (CGNs). Glutamate‐induced is also associated with intracellular [Ca 2+ ] i overload, generation reactive oxygen species (ROS), depression cell energy metabolism, cytochrome c release, and increase caspase‐3 activity. Pretreatment (3 h) red wine extract (5 μg/mL) ascorbic acid (30 μM) blocks CGNs. vivo...
<p>Supplementary Figure 1; Supplementary 2; Table 1 ; 3; 2</p>
<p>Representativeness of Study Participants</p>
<p>Representativeness of Study Participants</p>