A5076841070- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Metabolism, Diabetes, and Cancer
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Nutritional Studies and Diet
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Cancer, Lipids, and Metabolism
- Sleep and related disorders
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Cancer survivorship and care
- MicroRNA in disease regulation
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Dietary Effects on Health
- Estrogen and related hormone effects
- Nutrition and Health in Aging
- PI3K/AKT/mTOR signaling in cancer
Fondazione IRCCS Istituto Nazionale dei Tumori
2016-2025
Tumori Foundation
2018-2020
Predictive Science (United States)
2008
Several studies have shown that hormonal, metabolic and inflammatory mechanisms may affect breast cancer progression. We tested the prognostic value of syndrome in 110 postmenopausal patients, who participated a 1-year dietary intervention study. The risk adverse events after 5.5 years follow-up was examined by Cox' proportional hazard modelling, adjusting for hormone receptor status, stage at diagnosis serum testosterone level, which were to significantly prognosis. adjusted ratio...
The DIANA (Diet and Androgens)-5 study is a multi-institutional randomized controlled trial of the effectiveness diet based on Mediterranean macrobiotic recipes principles, associated with moderate physical activity, in reducing additional breast cancer events women early stage invasive at high risk recurrence because metabolic or endocrine milieu. intervention expected to reduce serum insulin sex hormones, which were prognosis previous studies.Between 2008 2010, randomly assigned 1208...
Hypotheses. Sleep disorders are associated with an increased risk of cancer, including breast cancer (BC). Physical activity (PA) can produce beneficial effects on sleep. Study design. We designed a randomized controlled trial to test the effect 3 months physical sleep and circadian rhythm level evaluated by actigraphy. Methods. 40 BC women, aged 35-70 years, were into intervention (IG) control group (CG). IG performed month aerobic exercise. At baseline after months, following parameters...
Abstract Metformin is a commonly prescribed type II diabetes medication that exhibits promising anticancer effects. Recently, these effects were found to be associated, at least in part, with modulation of microRNA expression. However, the mechanisms by which single modulated microRNAs mediate metformin are not entirely clear and knowledge such process could vital maximize potential therapeutic benefits this safe well-tolerated therapy. Our analysis here revealed expression miR-21-5p was...
Abstract Prospective studies show that high serum levels of androgens and estrogens are associated with increased incidence postmenopausal breast cancer. The aim the present analysis was to study prognostic value testosterone, estradiol related factors in cancer patients. One hundred ten patients without clinical recurrence were included study. After 5.5 years follow‐up, 31 developed distant metastasis (16), local relapse (4), or contralateral (11). risk adverse events relation hormone level...
Recent findings suggest that altered rest-activity circadian rhythms (RARs) are associated with a compromised health status. RARs abnormalities have been observed also in several pathological conditions, such as cardiovascular, neurological, and cancer diseases. Binge eating disorder (BED) is the most common disorder, prevalence of 3.5% women 2% men. BED its associate obesity motor inactivity could induce disruption negative consequences on health-related quality life. However, sleep...
APC-associated polyposis is a rare hereditary disorder characterized by the development of multiple adenomas in digestive tract. Individuals with need to be managed specialized multidisciplinary teams dedicated centers.
In this study, we investigated the progression of high-grade dysplasia (HGD)/CRC in patients with hereditary colorectal cancer syndromes (HCSS) and concomitant inflammatory bowel diseases (IBDs). We described natural history a series confirmed diagnosis (HCCSs) IBDs who were referred to Hereditary Digestive Tumors Registry at Fondazione IRCCS Istituto Nazionale dei Tumori Milan. Between January 1989 April 2024, among 450 APC-associated polyposis 1050 Lynch syndrome (LS), identified six (five...
Insulin may affect breast cancer (BC) risk and prognosis. Exercise reduces insulin in obese BC survivors. We designed a randomised controlled trial to test the effect of an aerobic exercise intervention (AEI) on parameters body composition non-obese women without resistance. Thirty-eight were into group (IG = 18) or control (CG 20). IG participated structured AEI for 3 months, while CG received only Word Cancer Research Fund/American Institute (WCRF/AICR) recommendation be physically active....
The association between consumption of fruit and vegetables risk ovarian cancer is still unclear from a prospective point view.Female participants (n = 325,640) the European Prospective Investigation into Cancer Nutrition study, free any at baseline, were followed on average for 6.3 years to develop cancer. During 2,049,346 person-years, 581 verified cases primary, invasive epithelial accrued. Consumption fruits as well subgroups vegetables, estimated validated dietary questionnaires...
Abstract Epidemiologic studies have shown that growth factors and inflammatory mechanisms may affect breast cancer risk prognosis. The present analysis on 110 postmenopausal patients tested if serum insulin-like factor I (IGF-I), platelet-derived (PDGF), fructosamine, C-reactive protein, a marker of inflammation, are associated with relapse. adverse events after 5.5 years follow-up was examined by Cox proportional hazards modeling, controlling for hormone receptor status, stage at diagnosis,...
Metabolic syndrome (MetS), conventionally defined by the presence of at least three out five dismetabolic traits (abdominal obesity, hypertension, low plasma HDL-cholesterol and high glucose triglycerides), has been associated with both breast cancer (BC) incidence prognosis. We investigated association between prevalence MetS a score adherence to World Cancer Research Fund (WCRF) American Institute for (AICR) recommendations prevention in cross-sectional study BC patients. The DIet...
Rest-activity circadian rhythm (RAR) is a marker of the timing system. Particular attention has been given to RAR characteristics in cancer diseases. Specifically, alterations parameters have found, at different stages clinical pathway, breast (BC) patients. No studies date analyzed survivors several years after diagnosis. The aim this study was determine by actigraphy population BC 5 primary diagnosis, and compare their with healthy controls. sample 28 women: 15 from diagnosis (BC-group) 13...
The Diet and Androgen-5 (DIANA-5) trial aimed at testing whether a dietary change based on the Mediterranean diet macrobiotic principles can reduce incidence of breast cancer (BC)-related events. We analyzed adherence to DIANA-5 recommendations by randomization group after 1 year intervention. evaluated association between changes in body weight metabolic syndrome (MS) parameters. BC women aged 35-70 years were eligible. After baseline examinations, randomized into an intervention (IG) or...
Abstract Vascular Endothelial Growth Factor A (VEGFA) is the most commonly expressed angiogenic growth factor in solid tumors and generated as multiple isoforms through alternative mRNA splicing. Here, we show that lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) ID4 (inhibitor of DNA-binding 4) protein, previously referred to regulators linear VEGFA , induce back-splicing exon 7, producing circular RNA circ_0076611. Circ_0076611 detectable triple-negative breast cancer...
Dietary interventions have been proposed as therapeutic approaches for several diseases, including cancer. A low-inflammatory Mediterranean dietary intervention, conducted a pilot study in subjects with Familial Adenomatous Polyposis (FAP), reduced markers of local and systemic inflammation. We aim to determine whether this diet may modulate faecal microRNA (miRNA) gene expression the gut.
Background. Insulin resistance is associated with higher breast cancer (BC) penetrance in BRCA mutation carriers. Metabolic syndrome (MetS), an insulin syndrome, can be reversed by adhering to the Mediterranean diet (MedDiet). In a dietary intervention trial on carriers, we evaluated adherence MedDiet, and association MetS, analyzing data from Diet Adherence Screener (MEDAS). Methods. or without BC, aged 18 70 years, were eligible for trial. After baseline examinations, women randomized...
Abstract Purpose: The DIANA-5 randomized controlled trial assessed the effectiveness of a diet based on Mediterranean and macrobiotic traditions (macro-Mediterranean diet) in reducing breast cancer recurrence. Patients Methods: study involved 1,542 patients with at high risk recurrence because estrogen receptor–negative cancer, or metabolic syndrome, plasma levels insulin testosterone. Women were randomly assigned to an active dietary intervention (IG) control group (CG). Both groups...