A5051872140- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Virus-based gene therapy research
- Helminth infection and control
- Opioid Use Disorder Treatment
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Pain Management
- Nuclear Structure and Function
- Parasitic Diseases Research and Treatment
- Fungal Biology and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Veterinary medicine and infectious diseases
- Bacterial Identification and Susceptibility Testing
- Nitric Oxide and Endothelin Effects
- DNA Repair Mechanisms
- Herpesvirus Infections and Treatments
- RNA Research and Splicing
- Parasite Biology and Host Interactions
- Nail Diseases and Treatments
- Primate Behavior and Ecology
- Analytical Methods in Pharmaceuticals
- CAR-T cell therapy research
- Plant Pathogens and Fungal Diseases
- Research on Leishmaniasis Studies
University of Bologna
2016-2019
Oncolytic herpes simplex viruses (oHSVs) showed efficacy in clinical trials and practice. Most of them gain cancer-specificity from deletions/mutations genes that counteract the host response, grow selectively cancer cells defective anti-viral response. Because deletions/mutations, they are frequently attenuated or over-attenuated. We developed next-generation oHSVs, which carry no deletion/mutation, specific retargeting to tumor cell receptors—e.g. HER2 (human epidermal growth factor...
This investigation provides for the first time a general view of prescribing patterns antimicrobials in small animal practice Emilia Romagna, Italy. In context project on antimicrobial resistance managed by Regional Veterinary Service, veterinary clinicians were invited to voluntarily complete an online questionnaire. was designed gather information practices and biosecurity measures understand perception issue specific this region total, 266 questionnaires correctly completed collected....
The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in LMNA gene, coding nuclear envelope protein Lamin A/C, and, as important, more general scope, complex process governing physiological aging humans. Here we give comprehensive description of peculiarities related to breeding mice over prolonged period time, and many features observed large colony 2-years period. We describe...
Graphical abstractAbstractIvermectin is an endectocide belonging to the macrocyclic lactone class, commonly used in dogs as a heartworm preventative and for treatment of several external internal parasite infections. Among analytical methods ivermectin determination plasma available literature, many require laborious clean-up step on SPE cartridge, use fluorescence detection instead more reliable mass spectrometry. In context project aimed at its pharmacokinetic evaluation this species,...
Introduction: Pentavalent antimony is the first choice drug for leishmaniasis in dog. Leishmaniasis has a complex pathogenesis and it manifests various clinical signs, some of which are often similar to those associated with toxicity induced by antimonial treatment. Among reasons this toxicity, also general problem drug’s quality been reported.
 Methodology: The local tolerability two commercially available meglumine antimoniate based veterinary products was evaluated 12 healthy dogs, 6...
Dermatophytosis caused by Microsporum canis is one of the most frequent skin diseases in animals and humans. Few antifungal agents are available against some them there emergence drug resistance. There urgent need for new therapeutic medicinal plants represent a good source such agents. The aim this study to investigate South African used ethnopharmacology as well other related plant species that could be combat dermatophytosis. minimum inhibitory activity acetone leaf extracts 16 was...
The aims of the present work were to study pharmacokinetics marbofloxacin 10% solution after single i.m. administration at doses 6, 8, 10 mg/kg b.w. in swine 20 weeks age, estimate PK/PD indices using bibliographic MIC90 values and assess tolerability drug.Marbofloxacin Cmax increased a dose dependent manner, however animals receiving b.w.dose revealed slightly lower AUCi compared those 8 b.w.This suggests potential alteration elimination mechanisms, evidenced by Cltot three...