A5064596821- Bone health and treatments
- Mycobacterium research and diagnosis
- Medical Imaging Techniques and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Radiopharmaceutical Chemistry and Applications
- Tuberculosis Research and Epidemiology
- Medical Imaging and Pathology Studies
- Infective Endocarditis Diagnosis and Management
- Morphological variations and asymmetry
- Antimicrobial Resistance in Staphylococcus
- Diagnosis and treatment of tuberculosis
- Nuclear Structure and Function
- Antifungal resistance and susceptibility
- Yersinia bacterium, plague, ectoparasites research
- Clostridium difficile and Clostridium perfringens research
- RNA Research and Splicing
- Infectious Diseases and Tuberculosis
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Chemotherapy-induced cardiotoxicity and mitigation
- Metabolism, Diabetes, and Cancer
- Parkinson's Disease Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Amoebic Infections and Treatments
Hospital César Milstein
2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2025
Istituto Ortopedico Rizzoli
2019-2022
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
1998-2008
CTO Andrea Alesini
2008
Center for Prevention and Treatment of Infections
2006
National Cancer Institute
2003
Instituto Nazionale Tumori Regina Elena
1999-2000
Tumori Foundation
1999-2000
Cancer Institute (WIA)
1997
Abstract Hutchinson–Gilford progeria syndrome (HGPS) causes premature aging in children, with adipose tissue, skin and bone deterioration, cardiovascular impairment. In HGPS cells mouse models, high levels of interleukin‐6, an inflammatory cytokine linked to processes, have been detected. Here, we show that inhibition interleukin‐6 activity by tocilizumab, a neutralizing antibody raised against receptors, counteracts progeroid features both fibroblasts Lmna G609G / mice. Tocilizumab...
The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in LMNA gene, coding nuclear envelope protein Lamin A/C, and, as important, more general scope, complex process governing physiological aging humans. Here we give comprehensive description of peculiarities related to breeding mice over prolonged period time, and many features observed large colony 2-years period. We describe...
Abstract Objectives The study of the development human bipedalism can provide a unique perspective on evolution morphology and behavior across species. To generate new knowledge these mechanisms, we analyze changes in both internal external growing talus sample modern juveniles using an innovative approach. Materials Methods consists high‐resolution microCT scans 70 juvenile tali, aged between 8 postnatal weeks 10 years old, from broad chronological range Middle/Late Neolithic, that is, 4800...
Extra-intestinal cryptosporidiosis, especially of the biliary and respiratory tract, is likely in course an intestinal involvement, whereas it rare without such a localization. We report case pulmonary cryptosporidiosis apparent involvement AIDS patient, with favourable outcome after antimicrobial combination therapy paromomycin plus azithromycin. The successful response to treatment was subsequently maintained by effective highly active antiretroviral (HAART). suggest that should be...
S-100 protein and neuron-specific enolase (NSE) have recently been proposed as serum markers for melanoma. In this study NSE levels were assayed by commercial IRMA methods in 53 patients with The overall prevalence of abnormal marker was similar (26%) (30%). 24 stages I II had uniformly normal levels, but observed 3 out the 12 stage (33%) 1 I. appears thus to be choice early stages, where its increase points disease progression. III IV values 34% 55% (p = < 0.05). latter group diagnostic...
We evaluated the diagnostic yield of 99Tcm-MIBI scintimammography in a relatively large series consecutive patients referred for breast surgery on basis physical examination or mammogram. uptake was correlated to tumour size, receptor status, neovascularity, proliferating activity, P-170 glycoprotein expression and patient's gonadal state. Three hundred our institution, with either positive mammogram palpable mass, were entered into study. All underwent scintimammography. Pathological status...
Abstract Background HIV-infected subjects have high incidence rates of Staphylococcus aureus infections, with both methicillin-susceptible and methicillin-resistant (MRSA) strains. Possible explanations could include the burden colonization, behavioral risk factors, frequent exposures to health care facilities patients. The purpose study was assess factors for clinically- significant (CS-MRSA) infections in patients admitted Infectious Diseases Units. Methods From January 1, 2002 December...
The development of bipedalism is a very complex activity that contributes to shaping the anatomy foot. talus, which starts ossifying in utero, may account for developing stages from late gestational phase onwards. Here, we explore early talus both its internal and external morphology broaden knowledge anatomical changes occur during development.The sample consists high-resolution microCT scans 28 modern juvenile tali (from 36 prenatal weeks 2 years), broad chronological range Late Roman...
Metal components of hip prostheses cause severe artifacts in CT images, influencing diagnostic accuracy. artifact reduction (MAR) software and virtual monoenergetic reconstructions on dual-energy (DECT) systems are possible solutions that should be considered. In this study, we created a customized adjustable phantom to quantify the severity periprosthetic tissues (cortical spongious bone, soft tissues) for prostheses. The was classified by different thresholds deviation from numbers...
We describe the first case of community-acquired bacteremia caused by Acinetobacter radioresistens; patient was a 32-year-old HIV-positive neutropenic woman. Ambiguous Gram staining and poor biochemical reactivity blood culture isolates misguided early diagnosis therapy. Bacterial identification based on 16S rDNA sequence analysis. A. radioresistens can be considered as cause opportunistic infection in immunodeficient patients.
Objective: Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes Parkinson's disease. In this work, we sought to investigate possible correlation between central and values a group 11 drug-naive patients with Methods: Densitometric measurements was accomplished as described recently, using monoclonal antidopamine antibody. Dopamine binding caudate putamen nuclei measured by means 123I-fluopane single-photon emission computed tomography...
Abstract Background Staphylococcus aureus expresses a variety of adhesins involved in the colonization host tissues. This study aimed to evaluate role staphylococcal surface proteins aetiology infective endocarditis (IE) and immune response infection. Materials methods The ELISA assays were used assess adherence S. isolates recovered from blood cultures 19 patients with IE (16 drug abusers) subendothelial matrix proteins. Anti‐adhesin antibody titre was measured incubating surface‐coated...
Abstract Two cases of community-acquired septicemia caused by serotype-O1 Yersinia pseudotuberculosis were diagnosed in middle-aged, HIV-positive, immunodeficient patients during an 8-month period. Bacterial isolates genetically indistinguishable, but no epidemiologic link between the 2 was established. HIV-related immunosuppression should be regarded as a risk factor for Y. septicemia.
Absence seizures represent a complex group of epilepsy, characterized by lapse consciousness with staring. Bilateral, synchronous, and symmetric bursts 3-Hz spike-and-wave discharges are observed on the electroencephalogram, whereas interictal background activity is normal. This kind epilepsy has to be differentiated from other generalized epilepsies such as juvenile absence myoclonic epilepsy. Moreover, seizures, together discharges, may coexist types frontal lobe temporal benign...
Chiari type I malformation is one of the posterior fossa maldevelopments with which different clinical manifestations have been associated. Seizures only recently associated malformation. This study reports on 4 children epilepsy (2M, 2F; age range 8–15 y) diagnosed by brain magnetic resonance imaging (MRI), in whom no cortical structural involvement was observed. In these patients an interictal ethylcysteinate-dimer-single-photon emission computed tomographic (ECD-SPECT) performed to define...