A5072071509- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Corneal Surgery and Treatments
- Immune cells in cancer
- Nerve injury and regeneration
- interferon and immune responses
- Ocular Oncology and Treatments
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Ferroptosis and cancer prognosis
- Graphene research and applications
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Nanocluster Synthesis and Applications
- Photochromic and Fluorescence Chemistry
Wenzhou Medical University
2017-2024
Affiliated Eye Hospital of Wenzhou Medical College
2022-2024
Abstract Graphene quantum dots (GQDs) are nano-sized graphene slices. With their small size, lamellar and aromatic-ring structure, GQDs tend to enter into the cell nucleus interfere with DNA activity. Thus, GQD alone is expected be an anticancer reagent. Herein, we developed that suppress growth of tumor by selectively damaging cancer cells. The amine-functionalized were modified targeting TAT peptides (TAT-NGs) further grafted cancer-cell-targeting folic acid (FA) PEG via disulfide linkage...
Purpose: Patients afflicted with dry eye disease (DED) experience significant discomfort. The underlying cause of DED is the excessive accumulation ROS on ocular surface. Here, we investigated nitrogen doped-graphene quantum dots (NGQDs), known for their ROS-scavenging capabilities, as a treatment DED. Methods: NGQDs were prepared by using citric acid and urea precursors through hydrothermal method. antioxidant abilities evaluated through: scavenging both extracellular intracellular,...
Abnormal thyrotropin receptor (TSHR) signaling drives a spectrum of diseases affecting hundreds millions globally, including Graves' disease (GD), ophthalmopathy (GO), hyperthyroidism, and thyroid cancers. Therefore, TSHR is considered an attractive therapeutic target with immense drug discovery potential. Currently, there are no clinically available inhibitors. To address this unmet medical need, we developed YC3, functional nucleic acid aptamer targeting TSHR, via innovative approach...
Background Immunogenic cell death (ICD) is a result of immune infiltration (ICI)-mediated death, which also novel acknowledgment to regulate cellular stressor-mediated including drug therapy and radiotherapy. Methods In this study, TCGA GEO data cohorts were put into artificial intelligence (AI) identify ICD subtypes, in vitro experiments performed. Results Gene expression, prognosis, tumor immunity, sensitivity showed significance among subgroups, Besides, 14-gene-based AI model was able...
Abstract Optic nerve regeneration remains challenging worldwide due to the limited intrinsic regenerative capacity of retinal ganglion cells (RGCs) and inhibitory microenvironment. Oxidative stress, induced by excessive reactive oxygen species (ROS) following optic injury, is associated with prolonged neuroinflammation, resulting in a secondary injury RGCs impairment axon regeneration. Herein, we developed bionic nanocomposite scaffold (GA@PDA) immunoregulatory ability for enhanced The...
A novel label-free Förster resonance energy transfer (FRET) sensor was developed from graphene oxide (GO) functionalized with doxorubicin (DOX) for selective and sensitive detection of dopamine (DA). Due to the competitive adsorption DOX DA onto GO, addition DOX–GO complex led a significant fluorescence enhancement caused by replacing GO-supported higher affinity GO. The unique interactions toward in conjugation property DOX, made as an ideal detect human serums cells.
To deal with tumor microenvironment, chemodynamic therapy has been developed, which uses nanocatalysts simulating peroxidase to convert high concentration hydrogen peroxide into toxic hydroxyl radicals in situ and effectively kills cells.
Oxidative stress is considered as a major factor causing retinal pigment epithelium (RPE) dysfunction and finally leading to diseases such age-related macular degeneration (AMD). Developing hydrogels for RPE cell delivery, especially those with antioxidant feature, emerging promising approach AMD treatment. Herein, readily prepared alginate-based hydrogel was developed serve cytoprotective agent cells against oxidative damage. Alg-BOB synthesized via conjugation of benzoxaborole (BOB) the...