A5000143005- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- MicroRNA in disease regulation
- Immune cells in cancer
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- Anesthesia and Pain Management
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Tactile and Sensory Interactions
- Advances in Oncology and Radiotherapy
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Glioma Diagnosis and Treatment
- Shoulder Injury and Treatment
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Photoreceptor and optogenetics research
- Surgical Simulation and Training
- Developmental Biology and Gene Regulation
- Fatty Acid Research and Health
- Botulinum Toxin and Related Neurological Disorders
Kansai Medical University
2017-2025
Kyoto Institute of Technology
2014-2017
Abstract In the M‐phase, nuclear membrane is broken down, nucleosomes are condensed as mitotic chromosomes, and transcription factors generally known to be dislocated from their recognition sequences dispersed cytoplasm. However, some have recently been reported remain on chromosomes facilitate rapid re‐activation of target genes in early G1‐phase. Paired‐like homeobox 2B (PHOX2B) a factor exhibiting chromosomal localization during M‐phase. PHOX2B mutations associated with congenital central...
Abstract The obturator nerve variably gives off the anterior, posterior, and hip articular branches along its course; however, all invariably pass through canal. Herein, we describe our block technique, which promises to deliver local anesthetic directly into We performed in six patients undergoing transurethral resection of bladder tumor under spinal anesthesia. also evaluated spread dye a cadaver. With patient placed lithotomy position, linear ultrasound transducer was on anterior part...
Elucidating fine architectures and functions of cellular synaptic connections requires development new flexible methods. Here, we created a concept called the "battle transgenes," based on which generated strategies using genetically engineered battles multiple recombinases. The enabled split-tunable allocation transgenes. We demonstrated versatility these technologies in inducing strong multi-sparse allocations Furthermore, combination our transgenic strategy expansion microscopy...
Glioblastoma multiforme (GBM) is the most prevalent malignant primary brain tumor with a high recurrence rate. Despite multimodal therapy including surgical resection, chemotherapy, and radiotherapy, median survival time after initial diagnosis of GBM approximately 14 months. Since cancer stem cells (CSCs) are considered leading cause recurrence, glioblastoma cell-targeted promising strategy for treatment GBM. However, because CSC heterogeneity has been implicated in difficulties CSC-target...
Mesenchymal glioma stem cells (MES-GSCs) are a major subtype of GSCs that reside within tissues and contribute to metastasis, therapy resistance, recurrence. However, the precise molecular mechanisms governing MES-GSC functions remain elusive. Our findings revealed expression levels miR-505-5p/-3p elevated in MES-GSCs compared with those proneural (PN)-GSCs, cell lines, normal brain tissue decreased differentiated MES-GSCs. We assumed would play distinctive roles performed loss-of-function...
Abstract Urodele amphibians have exceptional regeneration ability in various organs. Among these, the Iberian ribbed newt ( Pleurodeles waltl ) has emerged as a useful model organism for investigating mechanisms underlying regeneration. Neural stem cells (NSCs) are an important source of central nervous system (CNS) and their culture method vitro been well established. NSCs form spherical cell aggregates called neurospheres formation demonstrated vertebrates, including some urodele species,...
新型コロナウイルス感染症(COVID-19)によるパンデミックは,様々な分野において半ば強制的に非対面のオンライン化を促すこととなったが,対面実習の完全な代替に至っているとは言い難い.これは医学教育においても例外ではなく,特に人体の三次元構造を学習する肉眼解剖学実習は,その特性上オンラインでの代替は困難である.本研究では,肉眼解剖学を履修する医学部生を対象に,オープンリソースの医用画像からの三次元像再構築を目的とする特別課題を実施し,学生自身による三次元像再構築の可能性と,人体の三次元構造に対する理解度の向上に効果があるかを検証した.本研究では,肺を題材として取扱い,DICOMデータの入手法やソフトウェアの利用法に関するオンデマンド動画を教材として提供することで,非対面自学自習形式の課題を課した.その結果,本課題に参加した学生の96.0%が三次元再構築像を提示し,うち17.2%の学生は肺区域や気管支,血管の立体構造を含む完全な三次元再構築像を提示するに至った.また,本課題の得点,および参加・不参加により学生を4グループに分け,人体の三次元構造を問う実習形式試験の平均点を解析した結...