A5039779041- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Signaling Pathways in Disease
- Glycosylation and Glycoproteins Research
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Vibrio bacteria research studies
- Clostridium difficile and Clostridium perfringens research
- Galectins and Cancer Biology
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
Uniformed Services University of the Health Sciences
2018-2020
University of Maryland, Baltimore
2015
Shiga toxin (Stx)-producing Escherichia coli (STEC) causes foodborne outbreaks of bloody diarrhea. There are two major types immunologically distinct Stxs: Stx1a and Stx2a. is more cytotoxic to Vero cells than Stx2a, but Stx2a has a lower 50% lethal dose (LD50) in mice. Epidemiological data suggest that infections by STEC strains produce only progress often life-threatening sequela infection called hemolytic-uremic syndrome (HUS) isolates make or both In this study, we found an E. O26:H11...
To discern if there was a particular genotype associated with clinical enteroaggregative Escherichia coli (EAEC) strains isolated from deployed military personnel (DMP) travelers' diarrhea, we characterized collection of EAEC DMP to three different geographical locations. Although did not identify specific TD in DMP, found that at the first clinic visit were more likely encode dispersin gene aap than collected follow-up visits. A majority isolates typical adhered HEp-2 cells, formed...
In this study we compared nine Shiga toxin (Stx)-producing Escherichia coli O157:H7 patient isolates for Stx levels, stx-phage insertion site(s), and pathogenicity in a streptomycin (Str)-treated mouse model. The strains encoded stx2a, stx1a or stx2a stx2c. All of the elaborated 105-106 cytotoxic doses 50% (CD50) into supernatant after growth vitro as measured on Vero cells, showed variable levels increased production with sub-inhibitory ciprofloxacin (Cip). stx2a+stx2c+ were 90-100% lethal...
ABSTRACT Type IV pili (T4Ps) are surface appendages used by Gram-negative and Gram-positive pathogens for motility attachment to epithelial surfaces. In bacteria, such as the important pediatric pathogen enteropathogenic Escherichia coli (EPEC), during extension retraction, pilus passes through an outer membrane (OM) pore formed multimeric secretin complex. The is common assemblies, including related type 2 secretion (T2S) system 3 (T3S) system. N termini of monomers periplasmic in some...
Bacillus cereus G9241 caused a life-threatening anthrax-like lung infection in previously healthy human. This strain harbors two large virulence plasmids, pBCXO1 and pBC210, that are absent from typical B. isolates. The plasmid is nearly identical to pXO1 anthracis carries genes (pagA1, lef, cya) for anthrax toxin components (protective antigen [called PA1 G9241], lethal factor [LF], edema [EF], respectively). also has an intact hyaluronic acid capsule locus. pBC210 tetrasaccharide locus,...