A5036004411- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- RNA Research and Splicing
- Liver Disease and Transplantation
- RNA modifications and cancer
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- RNA and protein synthesis mechanisms
Princeton University
2019-2024
Hepatitis E virus (HEV) is an RNA responsible for over 20 million infections annually. HEV’s open reading frame (ORF)1 polyprotein essential genome replication, though it unknown how the different subdomains function within a structural context. Our data show that ORF1 operates as multifunctional protein, which not subject to proteolytic processing. Supporting this model, scanning mutagenesis performed on putative papain-like cysteine protease (pPCP) domain revealed six cysteines viral...
Hepatitis B virus (HBV) infection remains a major public health problem and, in associated co-infection with hepatitis delta (HDV), causes the most severe viral and accelerated liver disease progression. As defective satellite RNA virus, HDV can only propagate presence of HBV infection, which makes DNA standard biomarkers for monitoring virological response upon antiviral therapy, co-infected patients. Although assays have been described to quantify these nucleic acids circulation...
Abstract Modification of RNA with N 6 -methyladenosine (m A) has gained attention in recent years as a general mechanism gene regulation. In the liver, m A, along its associated machinery, been studied potential biomarker disease and cancer, impacts on metabolism, cell cycle regulation, pro-cancer state signaling. However these observational data have yet to be causally examined vivo. For example, neither perturbation key A writers Mettl3 Mettl14 , nor readers Ythdf1 Ythdf2 thoroughly...
Chronic infection with hepatitis B and delta viruses (HDV) is considered the most serious form of viral due to more severe manifestations accelerated progression liver fibrosis, cirrhosis, hepatocellular carcinoma. There no FDA-approved treatment for HDV current interferon-alpha suboptimal. We characterized early kinetics post inoculation incorporated mathematical modeling provide insights into host-HDV dynamics.We analyzed RNA serum viremia in 192 immunocompetent (C57BL/6) immunodeficient...
ABSTRACT Chronic infection with hepatitis B and delta viruses (HDV) is the most serious form of viral due to more severe manifestations an accelerated progression liver fibrosis, cirrhosis, hepatocellular carcinoma. We characterized early HDV kinetics post-inoculation incorporated mathematical modeling provide insights into host-HDV dynamics. analyzed RNA serum viremia in 192 immunocompetent (C57BL/6) immunodeficient (NRG) mice that did or not transgenically express receptor—human sodium...
Abstract Hepatitis E virus (HEV) is an RNA responsible for over 20 million infections annually. HEV’s open reading frame (ORF)1 polyprotein essential genome replication, though it unknown how the different subdomains function within a structural context. Our data show that ORF1 operates as multifunctional protein, which not subject to proteolytic processing. Supporting this model, scanning mutagenesis performed on putative papain-like cysteine protease (pPCP) domain revealed six cysteines...