A5052917625- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Time Series Analysis and Forecasting
- Cardiac Arrest and Resuscitation
- Traditional Chinese Medicine Studies
- Topic Modeling
- Health, Environment, Cognitive Aging
- COVID-19 diagnosis using AI
- Long-Term Effects of COVID-19
- Digital Mental Health Interventions
- COVID-19 Clinical Research Studies
- Anomaly Detection Techniques and Applications
- RNA Interference and Gene Delivery
- Health and Lifestyle Studies
- Protein purification and stability
- EEG and Brain-Computer Interfaces
Loyola University Chicago
2023-2024
Duke University
2022-2024
Enzo Life Sciences (United States)
2024
University of Florida
2023
Loyola University Medical Center
2020
Abstract Hepatitis D virus (HDV) requires hepatitis B surface antigen (HBsAg) for its assembly and release. Current HBV treatments are only marginally effective against HDV because they fail to inhibit HBsAg production/secretion. However, monotherapy with the nucleic acid polymer REP 2139-Ca is accompanied by rapid declines in both RNA. We used mathematical modeling estimate HDV-HBsAg-host parameters elucidate mode of action efficacy 12 treatment-naive HBV/HDV co-infected patients. The model...
Analyzing the interplay among serum HBV DNA, HBsAg, anti-HBs, and alanine aminotransferase (ALT) during nucleic-acid polymer (NAP)-based therapy for chronic hepatitis B provides a unique opportunity to identify kinetic patterns associated with functional cure.All participants HBeAg-negative infection in REP 401 study (NCT02565719) first received 24 weeks of tenofovir-disoproxil-fumarate (TDF) monotherapy. The early triple group (n = 20) next 48 TDF+pegylated interferon-α2a (pegIFN)+NAPs. In...
We propose and validate a domain knowledge-driven classification model for diagnosing post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID, using Electronic Health Records (EHRs) data.
Chronic infection with hepatitis B and delta viruses (HDV) is considered the most serious form of viral due to more severe manifestations accelerated progression liver fibrosis, cirrhosis, hepatocellular carcinoma. There no FDA-approved treatment for HDV current interferon-alpha suboptimal. We characterized early kinetics post inoculation incorporated mathematical modeling provide insights into host-HDV dynamics.We analyzed RNA serum viremia in 192 immunocompetent (C57BL/6) immunodeficient...
ABSTRACT Chronic infection with hepatitis B and delta viruses (HDV) is the most serious form of viral due to more severe manifestations an accelerated progression liver fibrosis, cirrhosis, hepatocellular carcinoma. We characterized early HDV kinetics post-inoculation incorporated mathematical modeling provide insights into host-HDV dynamics. analyzed RNA serum viremia in 192 immunocompetent (C57BL/6) immunodeficient (NRG) mice that did or not transgenically express receptor—human sodium...
Objective: Recent research has found that machine learning based analysis of patient speech can be used to classify Alzheimer’s Disease. We know no studies, however, which systematically explore the value pausing events in for detecting cognitive limitations. Using retrospectively acquired voice data from paragraph memory tests, we created two types pause features: a) number and duration pauses, b) frequency components immediately following pausing. Multiple models were assess how these...