A5089232109- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Chemokine receptors and signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Epigenetics and DNA Methylation
Heidelberg University
2018-2023
University Hospital Heidelberg
2020-2023
Background & AimsPancreatic ductal adenocarcinoma (PDAC) is frequently accompanied by excruciating pain, which has been associated with attraction of cancer cells and their invasion intrapancreatic sensory nerves. Neutralization the chemokine CCL2 reduced cancer-associated pain in a clinical trial, but there have no systematic analyses highly diverse families receptors PDAC.MethodsWe performed an open, unbiased RNA-interference screen mammalian chemokines co-cultures mouse PDAC (K8484)...
Cancer stem cells drive disease progression and relapse in many types of cancer. Despite this, a thorough characterization these remains elusive with it the ability to eradicate cancer at its source. In acute myeloid leukemia (AML), leukemic (LSCs) underlie mortality but are difficult isolate due their low abundance high similarity healthy hematopoietic (HSCs). Here, we demonstrate that LSCs, HSCs, pre-leukemic can be identified molecularly profiled by combining single-cell transcriptomics...
Abstract Cancer stem cells drive disease progression and relapse in many types of cancer. Despite this, a thorough characterization these remains elusive with i the ability to eradicate cancer at its source. In acute myeloid leukemia (AML), leukemic (LSCs) underlie mortality but are difficult isolate due their low abundance high similarity healthy hematopoietic (HSCs). Here, we demonstrate that LSCs, HSCs, pre-leukemic can be identified molecularly profiled by combining single-cell...
Background: Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy with poor overall survival. While classic chemotherapy and novel agents, such as Venetoclax, lead to remission in majority of patients, relapses driven by therapy-resistant leukemic stem cells (LSCs) are commonly observed. Eradication the residual LSC population therefore imperative improving patient LSCs characterized their distinct gene expression programs epigenetic signatures. Recent proteomics studies...