Objectives The aim of this study was to investigate the effect carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, semen analysis quality in male patients with epilepsy. Methods A total 59 epilepsy, which 30 were VPA 29 CBZ monotherapy, included between January 2015 March 2016. control group established healthy males. Luteinizing hormone (LH), follicle-stimulating (FSH), prolactin (PRL), free testosterone (fT), estradiol (E2), hormone-binding...

Background: To study whether enteral pretreatment with a synbiotic composition of lactic acid bacteria and bioactive fibers can reduce peritonitis-induced lung neutrophil infiltration tissue injury in rats. Materials Methods: Rats were divided into five groups, subjected to induction using cecal ligation puncture model (CLP). All animals pretreated for 3 weeks prior the CLP by daily gavage either (1) (1010 CFU Pediococcus pentosaceus 5-33:3, 1010 Leuconostoc mesenteroides 77:1, L. paracasei...

Summary To investigate the ability of some hematologic prognostic scores demonstrating inflammation in predicting sperm presence testicular extraction ( TESE ). We retrospectively investigated medical data 430 patients with diagnosis non‐obstruc tive azoospermia NOA ) who had undergone operation consecutively our institution between dates January 2009 and February 2017. In all, 352 , bilaterally palpable vas deferens, for first time, were included study. Patients genetic anomalies, genital...

Heparin-binding epidermal growth factor (HB-EGF) has pleiotropic biological functions in the female reproductive tract. HB-EGF a function menstruation cycle, implantation, decidualization, placenta development, and also inhibition of apoptosis. This study aims to investigate possible role missed abortion.Decidual placental tissue samples were obtained from women with unwanted pregnancy as control group abortions patient group. Immunohistochemistry was utilized compare expression fibroblast...

Abstract Aim: The goal of this study was to investigate the combined effects raloxifene and atorvastatin in aged ovariectomized rats during endothelial dysfunction atherosclerotic process. Material Methods: This conducted on 28 Wistar albino female randomly divided into four groups. All groups were one group kept as control (OVX). For weeks, remaining three treated with statin (OVX+AV), selective estrogen receptor modulator (OVX+RL), both (OVX+RL+AV), respectively. At end treatment period,...

The aim of this study was to determine the frequencies chromosomal abnormalities and Y-chromosome microdeletions in Turkish cases with primary male infertility a single center.Chromosomal were investigated 1696 between 2012 2017. Karyotype analyzes [azoospermia factor (AZF) regions] performed all by using standard cytogenetic methods multiplex polymerase chain reaction method, respectively.Chromosomal found 142 (8.4%; 142/1696). detected 46 (2.7%; 46/1696). AZFc region 20 (43%).This is one...

Summary Background There is a difference in the extent of remodelling allergic rhinitis (AR) and asthma. This may be attributed to local tissue response these mediators. Objectives The aim this study was compare vascular endothelial growth factor (VEGF) its receptor foetal liver kinase (Flk)‐1 expression between seasonal AR patients with or without asthma non‐allergic controls as well that Methods Thirteen subjects six were included study. Allergic sensitization demonstrated by skin prick...

<b><i>Objective:</i></b> To investigate the role of ultrasound guidance in intrauterine insemination (IUI). <b><i>Materials and Methods:</i></b> A retrospective study was conducted. The data collected from records 197 couples with unexplained infertility who underwent IUI a total 267 cycles vitro fertilization center our hospital between January 2009 December 2010. <b><i>Results:</i></b> Of cycles, 145 were carried out...

There are no well-defined findings about reasons for first trimester abortion in some pregnancy cases. Selectins cell adhesion proteins which important blastocyst implantation the decidua. The goal of study was to investigate role selectins loss by immunohistochemistry.Decidual and placental tissue samples have been obtained from women with unwanted as control group (n = 40) missed group. Immunohistochemistry technique has used compare P, L E-selectin expression fibroblast decidual cells...

Xenin-25 is a polypeptide having an insulinotropic effect via increasing the insulin-releasing action of glucose-dependent (GIP) and promoting beta cell survival proliferation. We aimed to assess serum xenin-25 levels in euglycemic pregnancies vs. complicated with gestational diabetes mellitus (GDM).Forty GDM 40 healthy age between 24 28 weeks were included. Following eight hours fasting, blood samples drawn from participants, subsequently, 75 g glucose was administered orally. Blood again...

Approximately 10% of all deaths in the world occur as a result stroke. Determination time schedule pathologic events stroke patient is invaluable for forensic specialist. The aim this study was to define macroscopic and microscopic changes that occurred rat model permanent focal ischemia providing useful clues evaluation patients. Male Wistar rats weighing 250 350 g were used study. Permanent brain applied by suture occlusion method. animals divided into 7 experimental groups (n = 6) with...

Objective:The implantation period of gestation is a complex process in which numerous molecular pathways play role.The Janus kinase/signal transducers and activators transcription (JAK/STAT) pathway one the evolutionarily conserved cascades used to transduce multitude signals for several biological events such as uterine receptivity.Previous studies have indicated that disrupted by lack proteins involved this pathway.However, our literature knowledge showed there no study evaluated...

Follicle-stimulating hormone (FSH) plays a key role in fertility and shows its effect through the FSH receptor (FSHR), which is localized cells.The aim of this study was to examine pregnancy outcomes responses controlled ovarian stimulation according FSHR polymorphism types.The retrospective, included patients who applied University Health Sciences Tepecik Training Research Hospital vitro fertilization (IVF) Unit during 2018 2019.Patients underwent IVF-intracytoplasmic sperm injection at...

To investigate whether adding letrozole in the early follicular phase of a gonadotropin-releasing hormone (GnRH) antagonist (GA) stimulation cycle improves vitro fertilization (IVF) outcomes poor responder patients.To be included this study, patients had to have at least one previous GA and subsequent with added (LzGA). A total 41 were identified based on Bologna criteria.The LzGA group lower dosage stimulating (FSH) (p = 0.001), duration days 0.015) GnRH 0.033) when compared controls....

Amaç: GnRH antagonist protokolü ve intrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan ovulasyonun tetiklendiği gün serum progesteron (P) düzeyi yüksek sikluslarda (≥1,5 ng/mL) prematür LH (luteinizan hormon) yükselmesinin gebelik sonuçları üzerine etkisini araştırmaktır. Gereç Yöntemler: Mart 2010-Temmuz 2015 tarihleri arasında, Tepecik Eğitim Araştırma Hastanesi, Kadın Hastalıkları Doğum Kliniği, Tüp Bebek Merkezi'ne başvuran hastaların kayıtlarından oluşan 2.111 siklustan dâhil edilme...

To evaluate the effects of c-Jun N-terminal kinase (JNK) inhibition and signal blocking on hypoxia (hypoxia-inducible factor 1-alpha (HIF-1α)), differentiation neurogenesis (bone morphogenetic protein (BMP4)), cytoskeleton (F-actin) in glioblastoma multiforme cells (GBMCs).We evaluated differences between GBMCs astrocytes terms abovementioned parameters assessed them with aim studying human (U-87 MG) (SVG p12). The were exposed to different doses JNK inhibitor, SP600125, for 24, 48, 72...

Amaç: Klinefelter sendromu (KS) olgularında testiküler sperm ekstraksiyonu (TESE) başarısı için prediktif parametrelerin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmamızda hastanemizde 2009-2014 yıllarında non-obstrüktif azospermi (NOA) nedeniyle TESE yapılmış 322 hastanın verileri retrospektif olarak incelendi. Bu hastalardan genetik analizi 47XXY - KS saptanan 29 hasta çalışmaya alınarak yaş, FSH, LH, FSH/LH oranı, prolaktin, T E2 değerleri Parametrelerin istatistiksel analizinde, p