A5047128833- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Muscle Physiology and Disorders
- Parkinson's Disease and Spinal Disorders
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Epilepsy research and treatment
- Genetic Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Inflammatory Myopathies and Dermatomyositis
- Pharmacological Effects and Toxicity Studies
- Glycogen Storage Diseases and Myoclonus
- Intracerebral and Subarachnoid Hemorrhage Research
- Autoimmune Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Ophthalmology and Eye Disorders
- Telemedicine and Telehealth Implementation
- Cardiomyopathy and Myosin Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Spinal Dysraphism and Malformations
- Hereditary Neurological Disorders
- Cerebral Venous Sinus Thrombosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Innovation and Socioeconomic Development
National Institute of Mental Health and Neurosciences
2022-2025
Leeds Teaching Hospitals NHS Trust
2025
Robert Jones and Agnes Hunt Orthopaedic Hospital
2025
Keele University
2025
University Health Network
2020-2024
Children's Hospital of Eastern Ontario
2024
University of Ottawa
2024
National Institute of Mental Health
2024
Ottawa Hospital
2024
MIND Research Institute
2024
Summary Coagulation and fibrinolytic activities were studied in 18 subjects with Behçet's disease compared results from 14 matched control patients suffering sero-negative arthritis. Significantly higher plasma concentrations (median range) found for the following variables: fibrinogen 3.7 (1.7-6.9) vs 3.0 (2.0-5.1) g/1, p <0.05; von Willebrand factor antigen, 115 (72-344) 74 (60-119)%, <0.002; plasminogen activator activity (106/ECLT2) 219 (94-329) 137 (78-197) units, tissue inhibitor...
Distal myopathies are a heterogeneous group of primary muscle disorders with recessive or dominant inheritance. ADSSL1 is muscle-specific adenylosuccinate synthase isoform involved in adenine nucleotide synthesis. Recessive pathogenic variants the gene located chromosome 14q32.33 cause distal myopathy phenotype. In this study, we present clinical and genetic attributes 6 Indian patients myopathy.
Background and Objectives Teleneurology has become instrumental in extending neurologic care remote underserved areas, enhancing access, potentially improving patient outcomes while reducing costs. This study evaluates the satisfaction of both patients healthcare providers with teleneurology services for common neurological disorders. Methods In this single-center, prospective observational study, 58 suffering from headache, epilepsy, stroke, or dementia were recruited through “Karnataka...
Subtrochanteric fractures present a challenge in treatment due to their varied aetiologies and complexities. Surgical intervention aims alleviate pain facilitate early mobility, but associated post-operative mortality remains considerable. The further increases should surgical complication occur, necessitating appropriate implant choice technique. While intramedullary nailing is the standard treatment, between short long nails contentious. This meta-analysis compare outcomes of...
<title>Abstract</title> Subacute sclerosing pan encephalitis (SSPE) is a slow viral disease that follows the wild-type measles infection of early childhood with subsequent progressive encephalitic illness seizures and global regression after long latent period. Mostly considered an invariably terminal degenerative disorder, intriguing variability in course plateaus spontaneous remissions, while rare, have been recognized. [1, 2] The predictors trajectory mechanisms at molecular immunological...
46, XY gonadal dysgenesis (GD) is rare form of sex development disorder. There have been five cases reported with GD and mutation in Desert Hedge Hog (DHH) gene peripheral neuropathy. To report first Indian case severe neuropathy a novel missense DHH gene. This retrospective study genetics done by clinical exome sequencing. We patient primary amenorrhea motor sensory Charcot’s joints. She presented at 30 years age, 15-year history complete loss temperature sensation inadvertent injuries...
Objectives The presence of obstructive sleep apnea (OSA) has been found to adversely affect the neurological recovery after acute ischemic stroke (AIS) in previous observational studies. However, most these studies, diagnosis OSA was based on oximetry data alone, raising concern accuracy as well estimation severity. Purpose our study determine prevalence and severity (based polysomnography American Association Sleep Medicine [AASM] criteria) patients with AIS compare post-stroke functional...
Abstract Introduction/Aims The purpose of this study was to evaluate the clinical profile myasthenia gravis (MG) in older patients and determine impact medical comorbidities on their MG status outcome. Methods This a retrospective chart review with symptom onset at or after 65 years age. Correlations were made between demographics, characteristics, Myasthenia Gravis Foundation America (MGFA) severity scale scores, Impairment Index (MGII) scores two outcome measures: MGFA Post‐Intervention...
Early use of immunosuppression has been suggested to prevent generalization ocular myasthenia gravis (OMG), but high-quality evidence is limited in this regard. We examined whether treatment with prednisone and other immunosuppressants reduce the risk OMG.
To describe the clinical profile, treatment response and predictors of outcome in patients with primary angiitis central nervous system (PACNS) from a single tertiary care center.Retrospective analysis consecutive diagnosed PACNS January 2000 to December 2015. Outcome was defined as poor when 6-month modified Rankin scale (mRS) ≥3.The median age 45 included this study 36 (range 19-70) years at disease onset 31 (68.9%) were males. The initial presentation ischemic stroke 15 (33.3%),...
Abstract Aim . Status epilepticus is a neurological emergency with significant morbidity and mortality. This study describes the clinical profile, treatment, predictors of outcome status in tertiary referral centre developing country aims to highlight similarities differences from data available western world. Methods A retrospective analysis patients treated for was conducted prospectively maintained records, between January 2000 September 2010. The demographic data, profile investigations...
Congenital myopathies (CMs) are a diverse group of inherited muscle disorders with broad genotypic and phenotypic heterogeneity. While the literature on CM is available from European countries, comprehensive data Indian subcontinent lacking.
Abstract Introduction There is limited evidence regarding the impact of World Health Organization (WHO) subtype thymoma on post‐thymectomy outcome thymoma‐associated myasthenia gravis (TAMG). The objective was to determine if pathological subtypes were associated with outcomes (MG), in patients TAMG. Methods We performed a retrospective study consecutive TAMG who attended neuromuscular clinic between January 2018 and December 2019 minimum follow‐up 1 y after thymectomy. Outcome measures MG...
Myasthenia gravis (MG) is an autoimmune disorder that frequently affects young women of reproductive age. The multidirectional interplay between MG, pregnancy, and fetal health poses a complex scenario for pregnant with MG the healthcare team. Here, we reviewed our local experience outcomes.We performed retrospective chart review patients attending Prosserman Family Neuromuscular Clinic from 2001 to 2019 who were referred high-risk pregnancy clinic. status was defined as stable, better, or...
The single simple question (SSQ) is a and validated asking what percentage of normal patient feels with respect to their myasthenia gravis (MG), 100% being normal. Patient acceptable symptom states (PASS) are based on dichotomous 'Yes' or 'No' response, whether satisfied overall current status thus measures holistic satisfaction MG state. Both patient-reported self-assessments but assess different dimensions MG. objective was determine thresholds for the SSQ when patients achieve an PASS...