A5091642059- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- Pharmacological Effects and Toxicity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Bone health and osteoporosis research
- Mobile Health and mHealth Applications
- Physical Activity and Health
- Vitamin D Research Studies
- Hip and Femur Fractures
- Skin Protection and Aging
- Streptococcal Infections and Treatments
- Global Health Workforce Issues
- Smoking Behavior and Cessation
- Obesity, Physical Activity, Diet
- Neurosurgical Procedures and Complications
- Stroke Rehabilitation and Recovery
- Antimicrobial Resistance in Staphylococcus
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Inflammatory mediators and NSAID effects
- Lung Cancer Treatments and Mutations
- Urban Green Space and Health
- Sleep and related disorders
- Bacterial Infections and Vaccines
- Inflammatory Myopathies and Dermatomyositis
Queen Mary Hospital
2011-2025
University of Hong Kong
2015-2025
University of Otago
2015-2024
Chinese University of Hong Kong
2012-2024
University of Auckland
2011-2021
University of California, Irvine
2020
Auckland District Health Board
2020
Southern District Health Board
2020
The University of Melbourne
2020
Sunderland Royal Hospital
2018
AimTo determine the effectiveness and cost-effectiveness of a mobile phone intervention to improve exercise capacity physical activity behaviour in people with ischaemic heart disease (IHD).
Background and Purpose: The current coronavirus disease 2019 (COVID-19) pandemic represents a global public health crisis, disrupting emergency healthcare services. We determined whether COVID-19 has resulted in delays stroke presentation affected the delivery of acute services comprehensive center Hong Kong. Methods: retrospectively reviewed all patients with transient ischemic attack admitted via pathway Queen Mary Hospital, Kong, during first 60 days since diagnosed case Kong (COVID-19:...
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations JAK2, CALR or MPL, but the contribution of inherited factors poorly characterized. Using a three-stage genome-wide association study 3,437 MPN cases and 10,083 controls, we identify two SNPs with significance JAK2(V617F)-negative MPN: rs12339666 (JAK2; meta-analysis P=1.27 × 10(-10)) rs2201862 (MECOM; P=1.96 10(-9)). Two additional SNPs, rs2736100 (TERT) rs9376092 (HBS1L/MYB), achieve when including...
Retinoic acid, an active metabolite of vitamin A, plays essential signaling roles in mammalian embryogenesis. Nevertheless, it has long been recognized that overexposure to A or retinoic acid causes widespread teratogenesis rodents as well humans. Although a short half-life, exposure high levels can disrupt development yet-to-be formed organs, including the metanephros, embryonic organ which normally differentiates into mature kidney. Paradoxically, is known either excess deficiency results...
Australia and Aotearoa New Zealand have the highest incidence of melanoma KC in world. We undertook a cost-of-illness analysis using Markov decision–analytic models separately for keratinocyte skin cancer (KC) each country. Using clinical pathways, probabilities unit costs health service medicine management were applied. estimated mean 95% uncertainty intervals (95% UI) Monte Carlo simulation. In Australia, first-year per patient ranged from AU$644 (95%UI: $642, $647) situ to AU$100,725...
Major intracerebral hemorrhage (ICH) trials have largely been unable to demonstrate therapeutic benefit in improving functional outcomes. This may be partly due the heterogeneity of ICH outcomes based on their location, where a small strategic could debilitating, thus confounding effects. We aimed determine ideal hematoma volume cutoff for different locations predicting retrospectively analyzed consecutive patients enrolled University Hong Kong prospective stroke registry from January 2011...
Aims To determine the rates and costs of nurse turnover, relationships with staffing practises, impacts on outcomes for nurses patients. Background In context nursing shortages, information turnover can improve staff management quality care. Methods Quantitative qualitative data were collected prospectively 12 months. A re-analysis these used descriptive statistics correlational analysis techniques. Results The cost per registered represents half an average salary. highest related to...
Purpose We investigated if programmed death-ligand 1 (PD-L1) expression levels were prognostic of survival outcomes after intensity-modulated radiation therapy (IMRT) for non-metastatic nasopharyngeal carcinoma (NPC). Methods and Materials 104 patients with NPC treated radical IMRT their PD-L1 by immunohistochemistry (IHC) which correlated endpoints including locoregional failure-free (LRFFS), progression-free (PFS), distant metastasis-free (DMFS) overall (OS). Results After a median...
Abstract We describe trends in acute rheumatic fever (ARF), heart disease (RHD), and RHD deaths among population groups New Zealand. analyzed initial primary ARF hospitalizations during 2000–2018 mortality rates 2000–2016. found elevated of for persons Māori (adjusted rate ratio [aRR] 11.8, 95% CI 10.0–14.0) Pacific Islander (aRR 23.6, 19.9–27.9) ethnicity compared with European/other ethnicity. also noted higher hospitalization 3.2, 2.9–3.5) 4.6, 4.2–5.1) these (Māori aRR 12.3, 10.3–14.6,...
99mTc-TRODAT-1 SPECT imaging is an technique, more commonly used in Asia, to diagnose Parkinson's disease (PD). This study evaluates the use of automated three-dimensional volume-of-interest (VOI) analysis diagnosing PD. images 76 patients (50 with PD and 26 without PD) were retrospectively analyzed. The specific binding ratio (SBR) was calculated using program. Multiple linear regression receiver operating characteristic curve analyses performed identify factors that affect SBR value...
Poor long-term blood pressure (BP) control due to undertreatment of hypertension is not uncommon after intracerebral hemorrhage (ICH). It heightens the risk ICH recurrence and subsequent stroke, which highest within first year. Promptly achieving BP targets would significantly reduce these risks. To accomplish this, upfront triple antihypertensive medications could be prescribed soon because many survivors require ≥3 antihypertensives. However, all suit this approach, particularly those with...
Recent intensive low-density lipoprotein cholesterol (LDL-C) lowering trials, including FOURIER, ODYSSEY OUTCOMES, and Treat Stroke to Target (TST) have mostly refuted the concern surrounding statin use, LDL-C lowering, intracerebral hemorrhage (ICH) risk. However, results from these trials may not be fully applied ICH survivors, as populations studied were mainly patients without prior ICH, in whom inherent risk is more than 10 times lower that of survivors. Although available literature on...
This paper reports on the cost-effectiveness of pedometer-based versus time-based Green Prescriptions in improving physical activity and health-related quality life (EQ-5D) a randomised controlled trial 330 low-active, community-based adults aged 65 years over. Costs, measured $NZ (NZ$1 = A$0.83, December 2008), comprised public private health care costs plus exercise-related personal expenditure. Based intention-to-treat data at 12-month follow up, pedometer group showed greater increase...
Background Survivors of intracerebral hemorrhage (ICH) are at high risk for recurrent stroke, which is associated with blood pressure control. Because most stroke events occur within 12 to 18 months the index ICH, rapid control likely be crucial. We investigated frequency and prognostic impact uncontrolled short-term hypertension after ICH. Methods Results analyzed data from Massachusetts General Hospital (n=1305) University Hong Kong (n=523). classified as controlled, undertreated, or...
Background Evidence describing the association between high‐dose benzodiazepine use and dementia has been conflicting. Most previous studies involved Caucasian populations, with only limited data on Chinese subjects. Possible differences exist populations regard to metabolism prescription practice. This study aimed assess in a population. Method A retrospective case–control was carried out all public hospitals under Hong Kong Hospital Authority West Cluster 2000 2015. The recruited 273...