A5007518629- Corneal Surgery and Treatments
- Connexins and lens biology
- Developmental Biology and Gene Regulation
- Marine Biology and Environmental Chemistry
- Neurobiology and Insect Physiology Research
- Marine and coastal plant biology
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Marine Ecology and Invasive Species
- Intraocular Surgery and Lenses
- Animal Genetics and Reproduction
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Marine Bivalve and Aquaculture Studies
- Protist diversity and phylogeny
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Physiological and biochemical adaptations
- Echinoderm biology and ecology
- Planarian Biology and Electrostimulation
- Genomics and Chromatin Dynamics
- COVID-19 Clinical Research Studies
- Receptor Mechanisms and Signaling
- Long-Term Effects of COVID-19
- Salivary Gland Disorders and Functions
- Skin and Cellular Biology Research
Manchester University NHS Foundation Trust
2024
Bicêtre Hospital
2021-2023
Massachusetts General Hospital
2020-2023
University of Illinois Urbana-Champaign
2012-2022
Broad Institute
2021-2022
Goodwin College
2005-2019
University of Illinois System
2019
University of Pittsburgh
2017
Urbana University
2010
Marine Biological Laboratory
1998-2002
The induction of the lens by optic vesicle in amphibians is often cited as support for view that a single inductive event can lead to determination multipotent tissue. This conclusion based on transplantation experiments whose results indicate many regions embryonic ectoderm which would normally form epidermis if brought into contact with vesicle. Although additional evidence argues during normal development other tissues, acting before vesicle, also contribute induction, it still widely...
Certain mRNAs have been shown to be segregated in different cells various metazoan embryos. These events represent aspects of autonomous mechanisms that establish particular embryonic cell fates and axial properties associated with asymmetric divisions. The spiralian lophotrochozoans (which include molluscs, annelids, nemerteans, gnathostomulids, dicyemid mesozoans, entoprocts, platyhelminthes) exhibit a highly conserved pattern early development involves stereotypical, divisions (termed...
BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, Genetics) was a prospective, longitudinal (1-year), genetic study in adults with at 28 US centers. The primary aim to examine the that candidate variants (1) motor/functional outcomes (2) stress-related outcomes. METHODS: For end points, 3 gene (ApoE ε4, BDNF [brain-derived neurotrophic factor], dopamine polygenic...
Few molecular comparisons have been made between the processes of embryogenesis and regeneration or transdifferentiation that lead to formation same structures. In amphibian, Xenopus laevis, cornea can undergo form a lens when original is removed during tadpole larval stages. Unlike process embryonic induction, cornea-lens elicited via single inductive interaction involving factors produced by neural retina. this study, we compared expression number genes known be activated various phases...
Using vital dye staining and the microinjection of fluorescent cell lineage-autonomous tracers, relationship between first cleavage plane prospective larval dorsoventral axis was examined in several sea urchin species, including: Strongylocentrotus purpuratus, S. droebachiensis, Lytechinus pictus, Clypeaster rosaceus, Heliocidaris tuberculata H. erythrogramma. The results indicate that there is no single early pattern for all urchins; however, specific relationships exist individual species....
In species of the frog genus Xenopus, lens regeneration occurs through a process transdifferentiation, in which cornea epithelial cells presumably undergo dedifferentiation and subsequently redifferentiate to form new lens. Experimental studies have shown that retina provides key signal required trigger this once original is removed. A previous study showed addition an exogenous fibroblast growth factor (i.e., FGF1 protein) could initiate transdifferentiation culture. To determine role FGF...
Background Survivors of intracerebral hemorrhage (ICH) are at high risk for recurrent stroke, which is associated with blood pressure control. Because most stroke events occur within 12 to 18 months the index ICH, rapid control likely be crucial. We investigated frequency and prognostic impact uncontrolled short-term hypertension after ICH. Methods Results analyzed data from Massachusetts General Hospital (n=1305) University Hong Kong (n=523). classified as controlled, undertreated, or...
Previous fate mapping studies as well the culture of isolated blastomeres have revealed that dorsoventral axis is specified early 2-cell stage in embryos direct developing echinoid, Heliocidaris erythrogramma. Normally, first cleavage plane includes animal-vegetal and bisects embryo between future dorsal ventral halves. Experiments were performed to establish whether set up prior division H. Eggs elongated fertilized silicone tubes a small diameter order orient spindle thus cell division....