A5038998615- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Antifungal resistance and susceptibility
- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Plant-Microbe Interactions and Immunity
- Fungal Infections and Studies
- Parasitic Diseases Research and Treatment
- Nematode management and characterization studies
University of Notre Dame
2021-2024
Microbial adhesion to medical devices is common for hospital-acquired infections, particularly urinary catheters. If not properly treated these infections cause complications and exacerbate antimicrobial resistance. Catheter use elicits bladder inflammation, releasing host serum proteins, including fibrinogen (Fg), into the bladder, which deposit on catheter.
Catheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired (HAIs). As 20 to 50% hospitalized patients receive catheters, CAUTIs are one the most common HAIs, resulting in increased morbidity, mortality, and health care costs. Candida albicans is second CAUTI uropathogen, yet relative its bacterial counterparts, little known about how fungal established. Here, we show that catheterized bladder environment induces Efg1- fibrinogen (Fg)–dependent biofilm...
For the fungal pathogen Candida albicans, genetic overexpression readily occurs via a diversity of genomic alterations, such as aneuploidy and gain-of-function mutations, with important consequences for host adaptation, virulence, evolution antifungal drug resistance. Given role on C. albicans biology, it is critical to develop harness tools that enable analysis genes expressed at high levels in cell. Here, we describe development, optimization, application novel, single-plasmid-based CRISPR...
ABSTRACT Catheter-associated urinary tract infections (CAUTIs) account for 40% of all hospital-acquired infections. Given that 20-50% hospitalized patients receive a catheter, CAUTIs are one the most common and significant medical complication as they result in increased morbidity, mortality, an estimated annual cost $340-370 million. Candida spp . – specifically albicans major causative agent (17.8%), making it second CAUTI uropathogen. Despite this frequent occurrence, cellular molecular...
Abstract For the fungal pathogen Candida albicans , genetic overexpression readily occurs via a diversity of genomic alterations, such as aneuploidy and gain-of-function mutations, with important consequences for host adaptation, virulence, evolution antifungal drug resistance. Given role on C. biology, it is critical to develop harness tools that enable analysis genes expressed at high levels in cell. Here, we describe development, optimization, application novel, single-plasmid-based...