A5029142797- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Urinary Tract Infections Management
- Urinary Bladder and Prostate Research
- Nail Diseases and Treatments
- Streptococcal Infections and Treatments
- Pelvic floor disorders treatments
- Enterobacteriaceae and Cronobacter Research
- Parasitic Infections and Diagnostics
- Probiotics and Fermented Foods
- Bladder and Urothelial Cancer Treatments
- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
University of Notre Dame
2021-2024
Catheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired (HAIs). As 20 to 50% hospitalized patients receive catheters, CAUTIs are one the most common HAIs, resulting in increased morbidity, mortality, and health care costs. Candida albicans is second CAUTI uropathogen, yet relative its bacterial counterparts, little known about how fungal established. Here, we show that catheterized bladder environment induces Efg1- fibrinogen (Fg)–dependent biofilm...
Understanding of how intracellular pathogens survive in their host cells is important to improve management diseases. This has been fruitful for bacteria, but it an understudied area fungal pathogens. Here we start elucidating and characterizing the strategies used by one commonest pathogens, Cryptococcus neoformans, intracellularly. The ability fungus inside main drivers disease progression, yet unclear whether C. neoformans resides a fully acidified, partially acidic, or neutral phagosome....
is an opportunistic fungal pathogen responsible for >150,000 deaths every year with a mortality rate as high 81%. This medical burden due, in part, to incomplete understanding of its pathogenesis. In previous study, we identified cryptococcal atypical pleiotropic drug resistance (PDR) transporter,
Urinary catheterization causes bladder damage, predisposing hosts to catheter-associated urinary tract infections (CAUTIs). CAUTI pathogenesis is mediated by damage-induced inflammation, resulting in accumulation and deposition of the blood-clotting protein fibrinogen (Fg) its matrix form fibrin, which are exploited uropathogens as biofilm platforms establish infection. Catheter-induced inflammation also results robust immune cell recruitment, including macrophages (Mϕs). A fundamental...
The antimicrobial peptide (AMP) circularized bacteriocin enterocin AS-48 produced by
ABSTRACT Catheter-associated urinary tract infections (CAUTIs) account for 40% of all hospital-acquired infections. Given that 20-50% hospitalized patients receive a catheter, CAUTIs are one the most common and significant medical complication as they result in increased morbidity, mortality, an estimated annual cost $340-370 million. Candida spp . – specifically albicans major causative agent (17.8%), making it second CAUTI uropathogen. Despite this frequent occurrence, cellular molecular...
Abstract Understanding of how intracellular pathogens survive in their host cells is important to improve management diseases. This has been fruitful for bacteria but it an understudied area fungal pathogens. Here we start elucidating and characterizing the strategies used by one commonest pathogens, Cryptococcus neoformans , intracellularly. The ability fungus inside main drivers disease progression, yet unclear whether C. resides a fully acidified, partially acidic, or neutral phagosome....