To investigate systemic and ocular hemodynamic risk factors for glaucomatous damage in eyes with normal tension glaucoma (NTG).Each patient diagnosed NTG underwent 24-hour monitoring of intraocular pressure (IOP) blood (BP), scanning laser polarimetry (GDx-VCC), a Humphrey visual field (HVF) examination. Multivariate regression models were used to evaluate potential factors: age, spherical equivalent, central corneal thickness (CCT), mean/peak in-hospital IOP, circadian IOP fluctuation,...

Purpose.: To investigate the relationship between clinical factors including 24-hour mean ocular perfusion pressure (MOPP, ⅔ × arterial [MAP] − intraocular [IOP]) and visual field (VF) progression in eyes with medically treated normal-tension glaucoma (NTG). Methods.: One hundred one of 101 NTG patients followed up for more than 4 years (mean follow-up, 6.2 ± 12.1 months) were included after retrospective chart review. Several demographic, systemic, risk factors, MOPP explored associations...

The study aimed to evaluate the quantitative characteristics of macular vessel density (VD) and foveal avascular zone (FAZ) in glaucoma using optical coherence tomography angiography (OCT-A).Cross-sectional, age- sex-matched case-control study.Fifty-two eyes 52 patients with primary open angle from healthy participants were recruited retrospectively. OCT-A was performed on a 3 x 3-mm region centered fovea. scans manually graded define FAZ. Parafoveal VD superficial deep retina analyzed...

Purpose: To investigate whether the area and shape of foveal avascular zone (FAZ) as assessed by optical coherence tomography angiography (OCTA) are altered in glaucomatous eyes with central visual field defects (CVFDs). Methods: A total 78 patients open-angle glaucoma or peripheral (PVFDs) confined to a single hemifield were studied retrospectively. Foveal circularity measured using OCTA images from superficial retinal layer. Central (VF) sensitivity Swedish Interactive Threshold Algorithm...

To study blood pressure (BP), intraocular (IOP), and mean ocular perfusion (MOPP) in patients with untreated normal tension glaucoma (NTG), to investigate the relationship between circadian MOPP fluctuation visual field status at initial presentation.IOP BP were evaluated hospital over 24 hours 132 NTG, measurements taken every 2 12 PM 10 AM following day, except for period 6 AM, during which 3 hours. was calculated from 24-hour IOP data. Patients classified into three groups-nondippers,...

Background and Purpose— An extradurally located cavernous sinus dural arteriovenous fistula (CSDAVF) exhibits different clinical behavior from other fistulas (DAVFs) between 2 leaves. The aim of this study is to define angiographic types CSDAVF associated with presenting symptom (Sx) venous drainage patterns. Methods— CSDAVFs during a mean 23-month follow-up period 58 patients (17 73 years, male:female ratio=8:50) were retrospectively analyzed. 3 CSDAF, ie, proliferative (PT), restrictive...

To investigate the characteristics of visual field (VF) progression in medically treated normal-tension glaucoma (NTG) patients (Koreans) with unstable ocular perfusion pressure (OPP).One hundred one eyes 101 NTG followed up for more than 4 years (mean follow-up, 6.2 ± 12.1 months) were included. Modified Anderson criteria (MC) and linear regression analysis (LA) VF mean deviation (MD) within central 10° to 24° area assessed determining groups lowest (LMF) highest (HMF) 24-hour OPP [MOPP =...

To characterize the circadian (24-hour) pattern of habitual-position intraocular pressure (IOP) and its association with visual field (VF) damage in eyes normal-tension glaucoma (NTG).A total 177 NTG were examined over a 3-year period. IOP was recorded at 8 AM, 10 12 PM, 2 4 6 3 AM by single, well-trained ophthalmology resident using hand-held tonometer. The peak hours seated analyzed all patients. Subgroup analysis also performed, groups defined time maximum IOP. relationship between...

To assess the diagnostic ability of foveal avascular zone (FAZ) parameters to discriminate glaucomatous eyes with visual field defects (VFDs) in different locations (central vs. peripheral) from normal eyes.Totally, 125 participants were separated into 3 groups: (n=45), glaucoma peripheral VFD (PVFD, n=45), and central (CVFD, n=35). The FAZ area, perimeter, circularity parafoveal vessel density calculated optical coherence tomography angiography images. other structural was determined...

Purpose To investigate the relationship between nocturnal blood pressure (BP) dip and parapapillary choroidal vessel density (pCVD) in patients with normal-tension glaucoma (NTG) Methods This study analyzed 267 eyes of untreated NTG who underwent 24-hour (h) intraocular (IOP) ambulatory BP monitoring habitual position. Patients were classified into 3 groups [non-dippers (nocturnal < 10%), dippers 10% 20%, over-dippers > 20%)], pCVDs measured by using optical coherence tomography...

The purpose of this study was to quantify the effect mitomycin C on rabbit keratocytes, with a view determining its potential in modulating corneal stromal wound healing. In addition, pathway by which regulation occurs investigated.Keratocytes were isolated from New Zealand White rabbits and cultured. Hoechst staining flow cytometric analyses annexin V used identify nature keratocyte response C. cultured keratocytes 0.005%, 0.01%, 0.02%, 0.04%, 0.06% evaluated lactate dehydrogenase (LDH)...

To evaluate the basic characteristics and reproducibility of anterior chamber angle (ACA) measurements determined by anterior-segment optical coherence tomography (AS-OCT) in open-angle primary closure suspect (PACS) patients.Thirty-nine 18 PACS patients were imaged for ACA AS-OCT. Subjects underwent imaging nasal, temporal inferior under conditions constant light, darkness. For analysis, we used three parameters handled Visante OCT software: opening distance at 500 μm (AOD(500)),...

To investigate the relationship between unstable mean ocular perfusion pressure (MOPP) and rate of paracentral visual field (PVF) progression in patients with medically treated normal-tension glaucoma (NTG).The data 157 eyes 122 NTG who were followed for more than 6 years (mean follow-up, 8.7 ± 12.6 months) had 5 reliable standard (VF) tests analyzed retrospectively. Groups highest, middle, lowest tertiles 24-hour MOPP fluctuation (HMF, MMF, LMF, respectively) compared terms rates change...

To evaluate the distribution of anterior chamber angle (ACA) parameters and to assess association these with age in Asian subjects. Four hundred thirty-nine consecutive Korean subjects aged from 30 89 were enrolled a university clinic. All participants scanned using segment optical coherence tomography (AS-OCT, Visante, version 2.0). We measured ACA such as depth (ACD), opening distance at 500 750μm (AOD(500,750) ), recess area (ARA(500,750) trabecular iris space (TISA(500,750) determined...

To study the surgical outcome and complications of Ahmed glaucoma valve (AGV) implantation with mitomycin C (MMC) in refractory glaucoma.The authors retrospectively reviewed records 40 eyes 37 consecutive patients who underwent combined AGV MMC (0.4 mg/mL; 5 minutes). All had a minimum 6 months follow-up. Outcome measures were best corrected visual acuity, intraocular pressure (IOP), number medications, success rates, incidence complications.The Kaplan-Meier life table analysis revealed that...

To characterize the circadian pattern of habitual-position intraocular pressure (IOP) and its association with ocular dimension in young myopic patients open-angle glaucoma (OAG).A total 108 OAG moderate to severe myopia (myopia group) 67 age-matched emmetropia or mild (control were recruited prospectively over 3 years. IOP was recorded 11 times a 24-hour period by single, well-trained ophthalmology resident using handheld tonometer.A 87 men 88 women included this study. Analysis entire...