A5009680638- Telomeres, Telomerase, and Senescence
- Single-cell and spatial transcriptomics
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Birth, Development, and Health
- COVID-19 Clinical Research Studies
- Nephrotoxicity and Medicinal Plants
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Health and Risk Factors
- Tracheal and airway disorders
- Trace Elements in Health
- Vascular Anomalies and Treatments
- MicroRNA in disease regulation
- Renal and Vascular Pathologies
- Reproductive Biology and Fertility
- Adipokines, Inflammation, and Metabolic Diseases
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Connective tissue disorders research
- Skin Protection and Aging
Université de Lorraine
2016-2025
Inserm
2016-2025
Défaillance Cardiovasculaire Aiguë et Chronique
2019-2024
Centre Hospitalier Régional et Universitaire de Nancy
2014-2024
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2021
Centre d’Investigation Clinique Innovation Technologique de Nancy
2019
Rutgers, The State University of New Jersey
2017
Délégation Centre-Est
2014-2015
Centre de Médecine Préventive
2015
Centre d'Investigation Clinique Pierre Drouin
2014
Short telomere length (TL) in leukocytes is associated with atherosclerotic cardiovascular disease (ASCVD). It unknown whether this relationship stems from having inherently short leukocyte TL (LTL) at birth or a faster LTL attrition thereafter. represents the highly proliferative hematopoietic system, whereas skeletal muscle minimally replicative tissue.We measured and (MTL) same individuals view to obtain comparative metrics for lifelong learn about temporal association of ASCVD.Our...
Short telomeres are associated with atherosclerosis. However, the temporal relationship between atherosclerosis and telomere length is unclear. The objective of this work was to examine formation progression carotid atherosclerotic plaques in relation dynamics. In a longitudinal study, comprising 154 French men women (aged 31-76 years at baseline), were quantified by echography, on leucocytes measured Southern blots baseline follow-up examinations. Telomere attrition rates during 9.5-year...
Adults with comparatively short or long leukocyte telomere length (LTL) typically continue to display LTL throughout life. This tracking stems from the inability of person‐to‐person variation in age‐dependent shortening during adulthood offset wide interindividual established prior adult However, children is unstudied. study aimed examine rates and their parents. Longitudinal ( n = 67) parents 99), whose ages at baseline were 11.4 ± 0.3 43.4 0.4 yr, respectively. was measured by Southern...
Abstract Profound T-cell lymphopenia is the hallmark of severe coronavirus disease 2019 (COVID-19). proliferation telomere length (TL) dependent and telomeres shorten with age. Older COVID-19 patients, we hypothesize, are, therefore, at a higher risk having TL-dependent lymphopenia. We measured TL by novel Telomere Shortest Length Assay (TeSLA), Southern blotting (SB) terminal restriction fragments in peripheral blood mononuclear cells 17 21 non-COVID-19 aged 87 ± 8 (mean SD) 9 years,...
Duration of post-vaccination protection against COVID-19 in nursing home (NH) residents is a critical issue. The objective this study was to estimate the duration IgG(S) response mRNA BNT162b2 vaccine NH with (COV-Yes) or without (COV-No) history SARS-CoV-2 infection.A 574 COV-Yes and COV-No were included 2 cohorts: Main (n = 115, median age 87 years) Confirmatory 459, 89 years). quantification carried out at three different time points following vaccine: (1st) seven (2nd) months after 2nd...
Abstract Telomere length (TL) limits somatic cell replication. However, the shortest among telomeres in each nucleus, not mean TL, is thought to induce replicative senescence. Researchers have relied on Southern blotting (SB), and techniques calibrated by SB, for precise measurements of TL epidemiological studies. SB provides little information 92 nucleus human cells. Therefore, known about accumulation short with age, or whether it lifespan. To fill this knowledge void, we used...
Endothelial dysfunction is a key factor in atherosclerosis. However, the link between endothelial repair and severity of atherosclerotic cardiovascular disease (ASCVD) unclear. This study investigates relationship ASCVD, markers inflammation, circulating progenitor cells, namely hematopoietic cells with paracrine angiogenic activity colony forming (ECFC). Two hundred forty-three subjects from TELARTA were classified according to presence clinical disease. ASCVD was assessed by number...
Mean telomere length in human leukocyte DNA samples reflects the different lengths of telomeres at ends 23 chromosomes and an admixture cells. However, only rudimentary information is available regarding distribution all cell types samples. Understanding configuration (LTLD) could be helpful capturing intrinsic elements that are not provided by mean (mLTL). The objective this study was to analyse LTLD its temporal variation adults. Leukocyte were donated on two occasions (8 years apart) 72...
Individuals with metabolic syndrome (MetS) are prone to develop heart failure (HF). However, the deleterious effects of MetS on continuum events leading cardiac remodeling and subsequently HF not fully understood. This study characterized simultaneously cardiac, vascular renal phenotypes in aging Spontaneously Hypertensive Heart Failure lean (SHHF+/? regrouping +/+ +/cp rats) obese (SHHFcp/cp, “cp” defective mutant allele leptin receptor gene) rats. We aimed refine milestones their onset...
Background Short leukocyte telomere length (TL) is associated with atherosclerotic cardiovascular disease. Endothelial repair plays a key role in the development of atherosclerosis. The objective was to examine associations between TL and proliferative dynamics endothelial colony‐forming cells (ECFCs), which behave as progenitor displaying activity. Methods Results To isolate ECFCs, we performed clonogenic assay on blood samples from 116 participants (aged 24–94 years) TELARTA (Telomere...
Short telomere length (TL) is associated with atherosclerotic cardiovascular disease (ACVD) and other age-related diseases. It unclear whether these associations originate from having inherently short TL or a faster attrition before during development. We proposed the blood-and-muscle model to assess dynamics throughout life course. Our objective was measure in leukocytes (LTL) skeletal muscle (MTL), which served as proxy of at birth. The delta (MTL–LTL) represented life-long attrition....
Lymphopenia due to a plummeting T-cell count is major feature of severe COVID-19. proliferation telomere length (TL)-dependent and TL shortens with age. Older persons are disproportionally affected by COVID-19, we hypothesized that those short have less capacity mount an adequate proliferative response SARS-CoV-2. This hypothesis predicts among older patients shorter telomeres peripheral blood mononuclear cells (PBMCs) will be associated lower lymphocyte count. Our sample comprised 17...
Short telomere length (TL) is associated with age-related diseases, in particular cardiovascular diseases. However, whether the onset and course of aortic stenosis (AS) linked to TL valves remains unknown.To assess dynamics (TL telomerase activity) possible implication AS.DNA was extracted from obtained 55 patients (78.2% men; age, 37-79 years), who had undergone replacement surgery due AS (AS group, n = 32), valve regurgitation dilation (Non-AS 23). measured by restriction fragment analysis...
Short leukocyte telomere length (LTL) is associated with atherosclerotic cardiovascular disease (ASCVD). Mendelian randomisation studies, using single nucleotide polymorphisms (SNPs) short LTL, infer a causal role of LTL in ASCVD. Recent results, the blood-and-muscle model, indicate that higher early life attrition, as estimated by ratio between and skeletal muscle (MTL), rather than at conception, MTL, should be responsible ASCVD-LTL connection. We combined MTL measurements SNPs profiling...
In adults, short leukocyte telomere length (LTL) is associated with metabolic disorders, such as obesity and diabetes mellitus type 2. These associations could stem from early life interactions between LTL disorders. To test this hypothesis, we explored the parameters well their evolution over time in children or without at baseline. Seventy-three (n = 73) attending our Outpatient Clinic for Prevention Management of Overweight Obesity Childhood Adolescence, aged 2–10 years (mean ± SD: 7.6...
Background: Balkan endemic nephropathy (BEN) is characterized with later onset and milder forms of hypertension, lower pulse wave velocity (PWV) than other end-stage kidney disease (ESKD). Longer telomeres are associated better cardiovascular (CV) prognosis. Therefore, we hypothesized that telomere length (TL) could be longer in BEN patients compared to ESKD patients. Methods: A total 124 undergoing hemodialysis (HD) (68 BEN, 56 non-BEN) were enrolled followed-up for 72 months. TL was...