Abstract Physical exercise reduces the effects of aging and cognitive decline by improving synaptic plasticity spatial learning. However, underlying neurobiological mechanisms are unclear. A total 45 Male SPF Sprague–Dawley rats were acclimatized then allocated into three groups, 15 in each group: saline control (DC) group, D-gal-induced (DA) + (DE) group. Six weeks intraperitoneal injections D-gal at a concentration 100 mg/kg body weight/d was injected to establish model DA DE groups....

This study aimed to investigate the changes in intestinal homeostasis and metabolism mice after methamphetamine (MA) administration exercise intervention. In this study, male C57BL/B6J were selected establish a model of methamphetamine-induced addiction, gut microbiota composition, short-chain fatty acids (SCFAs), amino acid levels assessed by 16S rRNA, liquid chromatography-tandem mass spectrometry, gas respectively. The results showed that 23 dominant microbiota, 12 acids, 1 SCFA...

Behavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease (AD). However, the molecular mechanism remains poorly understood due to a lack of sufficient pertinent biochemical evidence. We investigated potential effect on cognition hippocampal gene protein expression changes transgenic AD mouse model. Following twenty weeks treadmill exercise, mice showed improvement...

Exercise, an intervention with wide-ranging effects on the whole body, has been shown to delay aging. Due aging and exercise as modulator of metabolism, a picture how delayed D-galactose (D-gal)-induced in time-resolved manner was presented this paper. The mapping molecular changes response become increasingly accessible development omics techniques. To explore dynamic during exercise, serum rats D-gal-induced before, during, after analyzed by untargeted metabolomics. variation metabolites...

Abstract Background This study aimed to investigate the effects of physical exercise on learning, memory, and cellular dynamics in hippocampus aged mice, exploring potential as a non-pharmacological intervention mitigate age-related cognitive decline. Methods Eighteen 15-month-old C57BL/6J mice were divided into an aging group (O-Ctrl) (O-Ex), with 3-month-old young serving controls (Y-Ctrl). The O-Ex underwent 8-week low-intensity protocol. Post-exercise, all groups assessed using Barnes...

Purpose: Physical exercise mitigates the effects of aging and cognitive decline. However, precise neurobiological mechanisms underlying this phenomenon remain unclear. The primary aim study was to investigate protective effect on age-related memory deficits in prefrontal cortex (PFC) hippocampus using bioinformatic analysis biochemical verification. Methods: Young mice were subjected natural feeding or treadmill (12 m/min, 8 weeks). Cognitive function accessed Barnes maze novel object...

This study aimed to investigate the effect of long-term aerobic exercise on metabolism intestinal contents in APP/PS1 mice was studied using a non-targeted metabolomics technique based high-performance liquid chromatography-mass spectrometry (HPLC-MS) coupling, providing theoretical basis for regulate Alzheimer's disease (AD) organisms. Three-month-old male C57BL/6JNju mice, six wild-type (NC, n = 6); 12 double transgenic species total, were randomly divided into AD model (AM, 6) and (AE,...

Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms by which alleviates disorders are currently not fully understood. Based on this, the present study used untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) to analyze metabolic changes induced in brains of mice exercise intervention. It was found that after 2 weeks treadmill training, aerobic modulated MA-induced...

PURPOSE: To investigate the changes of serum metabolites in brain neural aging rats delayed by 8 weeks aerobic exercise. METHODS: A total 45 8-week-old male SPF-grade SD weighing 200 ± 10 g were selected and randomly divided into: normal control (C) group, (A) group exercise (AE) 15 each group. The was treated with saline senescent groups intraperitoneal injection D-gal at a daily dose 100 mg/kg for 6 . After 1 week acclimatization, C fed naturally AE subjected to interval training (AIT) on...

PURPOSE: The changes of metabolites in aging rats over time during aerobic exercise were monitored to provide a theoretical basis for clinical studies on delaying aging. METHODS: 15 young (control group, C) and 30 rats, which randomly divided into two groups, group (A) (AE). Group AE was performed with the intervention 8 weeks, no-weight treadmill exercise. speed increased from 6 m/min first day 12 60 min fifth maintained that until end 8th week groups C A fed normally. Blood all collected...

Abstract Background Methamphetamine (METH) abuse can inflict severe harm to the human body, particularly brain, resulting in profound and enduring neurotoxic consequences, which culminate cognitive dysfunction impairment of learning memory. Physical exercise stimulate both structural functional adaptations central nervous system. The primary objective this study was elucidate safeguarding effect underlying mechanisms treadmill intervention brains METH-addicted mice. Results Two-month-old...