A5061572070- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Infant Health and Development
- Liver Disease and Transplantation
- Malaria Research and Control
- Mosquito-borne diseases and control
- Microscopic Colitis
- Streptococcal Infections and Treatments
- Clinical Nutrition and Gastroenterology
- Rabies epidemiology and control
- Diet and metabolism studies
- Dermatology and Skin Diseases
- Protein Hydrolysis and Bioactive Peptides
- Vector-borne infectious diseases
- Polyamine Metabolism and Applications
- Liver Disease Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Meat and Animal Product Quality
- Biochemical effects in animals
- Disaster Response and Management
- Congenital gastrointestinal and neural anomalies
- Genomics and Phylogenetic Studies
- Tryptophan and brain disorders
Baylor College of Medicine
2016-2023
Texas Children's Hospital
2016-2021
King Mongkut's Institute of Technology Ladkrabang
2019-2021
Chulalongkorn University
2014
Mahidol University
2007-2008
Bangkok Hospital
2005
Among 777 patients transferred to 4 hospitals in Bangkok from southern Thailand after the tsunami of 26 December 2004, there were 515 with skin and soft-tissue infections. The most common organisms isolated Aeromonas species (145 [22.6%] 641 isolates 305 patients). Most susceptible aminoglycosides, third- fourth-generation cephalosporins, quinolones, imipenem but resistant amoxicillin-clavulanate first-generation cephalosporins.
Patients with cirrhosis are often exposed to antibiotics that can lead resistance and fungal overgrowth. The role of fecal microbial transplant (FMT) in restoring gut function is unclear cirrhosis. In a Food Drug Administration–monitored phase 1 clinical safety trial, patients decompensated on standard therapies (lactulose rifaximin) were randomized standard‐of‐care (SOC, no antibiotics/FMT) or 5 days broad‐spectrum followed by FMT from donor enriched Lachnospiraceae Ruminococcaceae....
Integration of antibiotic and probiotic therapy has the potential to lessen public health burden antimicrobial-associated diseases. Clostridium difficile infection (CDI) represents an important example where rational design next-generation probiotics is being actively pursued prevent disease recurrence. Because intrinsic resistance clinically relevant antibiotics used treat CDI (vancomycin, metronidazole, fidaxomicin) a desired trait in such species, we screened several bacteria identified...
Abstract Background Accurate diagnosis of Plasmodium spp. is essential for the rational treatment malaria. Despite its many disadvantages, microscopic examination blood smears remains current "gold standard" malaria detection and speciation. PCR assays offer an alternative to microscopy which has been shown have superior sensitivity specificity. Unfortunately few comparative studies done on various molecular based speciation methods. Methods The sensitivity, specificity cost effectiveness...
Clostridium difficile is the main cause of hospital-acquired diarrhea and colitis known as C. difficile-associated disease (CDAD).With increased severity failure treatment in CDAD, new approaches for prevention treatment, such use probiotics, are needed. Since pathogenesis CDAD involves an inflammatory response with a massive influx neutrophils recruited by interleukin (IL)-8, this study aimed to investigate probiotic effects Lactobacillus spp. on suppression IL-8 production infection. We...
The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regulate the maturation of enteric nervous system (ENS). Because microbiota-derived signals that modulate ENS development are poorly understood, we examined physiological impact broad spectrum antibiotic, vancomycin-administered postweaning on colonic motility, neurochemistry neurons, neuronal excitability. functional vancomycin neurons was investigated by Ca 2+...
ABSTRACT Recent studies using laboratory clones have demonstrated that several antiretroviral protease inhibitors (PIs) inhibit the growth of Plasmodium falciparum at concentrations may be clinical significance, especially during human immunodeficiency virus type 1 (HIV-1) and malaria coinfection. Using isolates, we now demonstrate in vitro effectiveness two HIV-1 aspartic PIs, saquinavir (SQV) ritonavir (RTV), against P. vivax ( n = 30) 20) from populations subjected to high levels...
Frequent and excessive use of antibiotics primes patients to
Background: Little is known regarding the clinical impact of treatment and duration probiotic VSL#3 on gut microbiome function in irritable bowel syndrome (IBS). As part a safety trial, we assessed effect abdominal pain, stooling, permeability, composition function. Methods: Adults with IBS were randomized into an open label trial to receive for 4 or 8 weeks. Adverse events, stooling patterns recorded daily. Gut fecal bile acid levels, profiled at baseline after treatment. Results: Fifteen...
Fecal microbiota transplantation (FMT) has proven to be an effective treatment for recurrent Clostridioides difficile infection (rCDI) in both adult and pediatric patients. However, as microbiome development is a critical factor children, it remains unclear whether fecal donors can provide age-appropriate functional restoration To address this issue, we conducted integrated systems approach found that concordant donor strain engraftment, along with metabolite restoration, are associated FMT...
Lactobacillus rhamnosus is a facultative, lactic acid bacterium in the phylum Firmicutes. spp. are generally considered beneficial, and specific strains of L. validated probiotics. We describe draft genomes three (L31, L34, L35) isolated from feces Thai breastfed infants, which exhibit anti-inflammatory properties vitro. The range between 2.8 - 2.9 Mb, contain approximately 2,700 protein coding genes.