A5100623245- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- HER2/EGFR in Cancer Research
- Inflammatory Biomarkers in Disease Prognosis
- Peptidase Inhibition and Analysis
- Inflammatory Bowel Disease
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neutropenia and Cancer Infections
- Gastrointestinal motility and disorders
- Cardiovascular Health and Risk Factors
- Microscopic Colitis
- Blood disorders and treatments
- Artificial Intelligence in Healthcare
- Cancer survivorship and care
- Diabetes, Cardiovascular Risks, and Lipoproteins
Nanjing Medical University
2013-2025
Jiangsu Cancer Hospital
2017-2025
Cleveland Clinic
2013-2015
Sun Yat-sen University
2011
Sixth Affiliated Hospital of Sun Yat-sen University
2011
Rationale: Mesenchymal stem cells (MSCs) have been the focus of many studies because their abilities to modulate immune responses, angiogenesis, and promote tumor growth metastasis. Our previous work showed that gastric cancer MSCs (GCMSCs) promoted escape by secreting IL-8, which induced programmed cell death ligand 1 (PD-L1) expression in GC cells. Mounting evidence has revealed PD-L1 is related intrinsic properties. Here, we investigated whether GCMSCs maintained a pool (CSCs) through...
CXCL12 exerts a wide variety of chemotactic effects on cells. Evidence indicates that CXCL12, in conjunction with its receptor, CXCR4, promotes invasion and metastasis tumor Our objective was to explore whether the CXCL12-CXCR4 biological axis might influence behavior pancreatic cancer cells.Miapaca-2 human cells were cultured under three different conditions: normal medium (control), + recombinant (CXCL12 group), or CXCR4-inhibitor AMD3100 (AMD3100 group). RT-PCR applied detect mRNA...
Epidermal growth factor receptor (EGFR) sensitive mutation is one of the effective targets targeted therapy for non-small cell lung cancer (NSCLC). However, due to difficulty obtaining some primary tissues and economic factors in underdeveloped areas, patients cannot undergo traditional genetic testing. The aim this study establish a machine learning (ML) model using non-invasive peripheral blood markers explore biomarkers closely related EGFR status NSCLC evaluate their potential prognostic...
We previously demonstrated a significant colorectal neoplasia risk in inflammatory bowel disease (IBD) patients with mucosal changes indefinite for dysplasia (IND) and the potential diagnostic utility of p53 cytokeratin 7 immunohistochemistry IBD-associated neoplasia. The primary aim this exploratory study was to determine predictive value two markers IBD-IND population.We identified 44 eligible cases IBD IND colon biopsy from our pathology database. semi-quantified expression biopsies by...
Bevacizumab has played an important role in the systemic treatment of patients with advanced non-small-cell lung cancer (NSCLC) without gene mutation. In recent years, bevacizumab biosimilar received marketing approval based on results phase III clinical studies. However, more data are needed to verify efficacy and safety application.We identified 946 locally or metastatic NSCLC who were treated from January 1, 2019 November 30, 2021. Comparisons statistical analyses made terms safety....
Abstract Objectives Gastric cancer mesenchymal stem cells (GC‐MSCs) can promote the development of tumour growth. The tumour‐promoting role tumour‐associated MSC s and T has been demonstrated. as major immune may influence induce a pro‐tumour phenotype in s. This study focused on whether CD 4 + affect GC ‐ to gastric Materials methods upregulation programmed death ligand 1 ( PD ‐L1) expression through phosphorylated signal transducer activator transcription (p‐ STAT 3) signalling pathway was...
Objective: The study aimed to explore the efficacy of pharmacokinetic-based 5-fluorouracil dose management by plasma concentration test in advanced colorectal cancer treatment. Methods: 153 samples patients were enrolled and randomly assigned a control group an experimental group. All received double-week chemotherapy with 5- fluorouracil (four weeks used as one period), duration ranged from 2 6 periods. In first period, all administered classic strategy body surface area (BSA). Results:...
There is controversy over whether constipation as the only symptom should be an indication for routine diagnostic colonoscopy. The study was carried out to assess prevalence of abnormal pathology on colonoscopy and risk factors colonic neoplasia in patients with but without 'high symptoms'.A cross-sectional, single-centre conducted individuals who underwent sole between 2005 2008. Standardized endoscopic reports were reviewed. Univariable multivariable analyses performed.A total 786 (595...
Low bone mineral density (BMD) or low mass is common in patients with inflammatory bowel disease (IBD). Studies have shown that BMD also ulcerative colitis (UC) even after colectomy and ileal pouch-anal anastomosis (IPAA). The reported frequency of osteopenia ranged from 26-55% osteoporosis 13-32% IPAA. Increasing age, body index, lack calcium supplementation high activity villous atrophy the ileo-anal pouch are risk factors for patients. Bone loss IBD ostomy. Current professional society...
Background:The aim of this study was to evaluate the efficiency combination Paris and Vienna classifications in a follow-up gastric epithelial neoplasia (GEN) patients. Material andMethods:This conducted between January 2003 September 2010, during which 170 biopsy-proven GEN patients were followed up by gastroenterologists pathologists according our regimen (modified classification). Results:In total, 161 with low-grade (LGN) 9 high-grade (HGN) randomly enrolled study. Eighteen depressed...
9014 Background: This study aimed to evaluate the safety and preliminary efficacy of YK-029A, a novel third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in treated or untreated patients with advanced NSCLC. Methods: dose-escalation dose-expansion phase 1 trial recruited previously EGFR ex20ins mutant locally metastatic NSCLC T790M rare mutations. In phase, mutation were enrolled. YK-029A was given at doses 50, 100, 150, 200 250 mg/day (3+3 design). T790M,...
Abstract This study aimed to assess the clinical efficacy and safety of aprepitant injection in preventing treating nausea vomiting induced by platinum‐based chemotherapy lung cancer patients. Forty‐eight patients with advanced first‐line undergoing cisplatin‐ or carboplatin‐based were randomly assigned either experimental group control group, 24 each group. The received dexamethasone palonosetron for prevention, whereas dexamethasone, palonosetron, injection. compared incidence acute...
Lung cancer is the leading cause of cancer-related death, which non-small cell lung (NSCLC) most common type. Immune checkpoint inhibitors (ICIs) have now become one main treatments for advanced NSCLC. This paper retrospectively investigated effect peripheral blood inflammatory indexes on efficacy immunotherapy and survival patients with cancer, in order to find strategies guide NSCLC.Patients who were hospitalized The Affiliated Cancer Hospital Nanjing Medical University from October 2018...
Abstract Purpose Bevacizumab is important in the systemic treatment of patients with advanced non-small-cell lung cancer (NSCLC) without gene mutation. biosimilar has received marketing approval based on results phase III clinical studies. It first retrospective study to verify efficacy and safety bevacizumab application. Methods We identified 946 locally or metastatic NSCLC treated bevacizumab. Efficacy evaluation was performed according RECIST v1.1. Adverse events were graded following...
Objective To study the risk values of glycosylated hemoglobin (HbA1c) screening patients with diabetes mellitus(DM) and pre-diabetes(PreD) in different age sex. Methods HbA1c results from10 840 Taizhou Hospital 2012 were retrospectively collected, CHAID analysis decision tree was used preliminary hierarchy. Age further divided into five groups according to results, then one-way ANOVA linear regression utilized determine differences between prediction intervals(PI) HbA1c,respectively....