A5089495374- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Toxoplasma gondii Research Studies
- Amoebic Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Research on Leishmaniasis Studies
- T-cell and Retrovirus Studies
- Insects and Parasite Interactions
- Helminth infection and control
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
- Tuberculosis Research and Epidemiology
- Alcohol Consumption and Health Effects
- Reproductive System and Pregnancy
- Science and Education Research
- Healthcare Regulation
- Virus-based gene therapy research
Universidade Vila Velha
2015-2024
Universidade Federal do Espírito Santo
2010-2021
Cambridge University Press
2016
New York University Press
2016
Duke Medical Center
2010
Hospital Nossa Senhora da Conceição
2005-2008
Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória
1997-2008
Universidade Federal de Minas Gerais
2005
University of Finance and Economics
1998
The Alberta Paraplegic Foundation
1996
Liver inflammation is greater in nonalcoholic steatohepatitis (NASH) than steatosis, suggesting that immune responses contribute to fatty liver disease (NAFLD) progression. Livers normally contain many natural killer T (NKT) cells produce factors modulate inflammatory and fibrogenic responses. Such are relatively depleted but their status more advanced NAFLD uncertain. We hypothesized NKT accumulate promote fibrosis progression NASH. aimed determine if livers become enriched with during...
We report a significantly higher prevalence of intestinal nematodes in patients with pulmonary tuberculosis (TB) compared to matched control group: 33/57 (57.8%) TB and 18/86 (20.9%) the group; OR = 5.19; 95% CI 2.33-11.69; p 0.000). When eosinophilia was also among those parasites (69.8%) without this condition (45.6%). hypothesized that immune modulation induced by is factor enhances infection/progression seen consequence helminth infection.
In a prospective study between February 2003 and June 2004, stool specimens of children less than 2 years age with diarrhoea (n=218) without (n=86), living in Vitória, Espírito Santo, Brazil, were examined for the presence diarrhoeagenic Escherichia coli. E. coli isolates tested by colony blot hybridization specific DNA probes designed to detect EPEC, ETEC, EIEC, EAEC, DAEC EHEC/STEC. Diarrhoeagenic strains detected as sole pathogen stools 92 (30.3 %) children, including 72 (33.0 20 (23.2...
Summary Resistance to intracellular pathogens such as Mycobacterium leprae is dependent upon an effective T helper type 1 (Th1)-type immune response. On the other hand, intestinal helminths are known subvert host's response towards either a Th2-type or regulatory cell up-regulation, which may affect ability mount mycobacteria. Here, we report significant association between helminth infections and lepromatous leprosy [odds ratio (OR), 10·88; confidence interval (CI) 95%: 4·02–29·4; P...
In order to investigate epidemiological aspects of hepatocellular carcinoma (HCC) in Brazil, basic informations about cases diagnosed from January 1992 December 1994 were requested several medical centers different Brazilian States. A simple questionnaire included age, sex, alcohol abuse (over 80g/day), associated liver cirrhosis, persistent HBV infection (HBsAg), HCV (anti-HCV) and serum levels alpha fetoprotein. 287 cases, over 16 years old, 19 8 States (Pará, Bahia, Minas Gerais, Espirito...
Schistosomiasis is a major cause of portal hypertension worldwide. It associates with fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. We evaluated hypothesis schistosome eggs release factors directly stimulate liver cells to produce osteopontin (OPN), pro-fibrogenic protein stimulates hepatic stellate become myofibroblasts. also investigated utility OPN as biomarker and/or severity hypertension. Cultured...
Background Significantly higher prevalence of Strongyloides stercoralis has been reported in chronic alcoholic patients. The aim this investigation was to report the larvae stools patients with known daily ethanol intake. Methods From January 2001 through December 2003 results fecal examinations and intake were retrieved from records 263 590 non-alcoholic male that sought health care at outpatients unit University Hospital C A Moraes. Alcoholic separated into four groups, 150g intervals...
Brazil is one of the regions with highest prevalences Toxoplasma gondii in humans and animals. Because free-range chickens become infected by feeding from ground contaminated oocysts, prevalence T. this host has been widely used as an indicator strains prevalent environment. The genetic variability among isolates different healthy sick hosts all over world recently studied. Three clonal lineages (Types I, II III) were initially recognised predominant Western Europe United States. are...
To report the etiology of liver cirrhosis cases diagnosed at University Hospital in Vitoria, Espirito Santo, Brazil.METHODS: The medical charts patients with who presented to Vitoria were reviewed.Chronic alcoholism and presence hepatitis B or C infections (HBV HCV, respectively) pursued all cases.RESULTS: sample consisted 1,516 (male:female ratio 3.5:1, aged 53.2¡12.6 years).The following main etiological factors observed: chronic alone (39.7%), association HBV HCV (16.1%),HCV (14.5%)...
Intestinal helminths are known to subvert the host's immune response towards a Th2 response, which in turn may lead both eosinophilia and high immunoglobulin E titers often associated with these parasites. Mycobacterium leprae infection different clinical pathological forms. Multibacillary forms cytokines, whereas paucibacillary Th1 cytokines. We report significantly higher frequency of intestinal helminthic infections patients lepromatous form, multibacillary form leprosy (odds ratio, 2.99;...
This report describes the prevalence of anti-HAV antibodies in children from elementary school Municipality Vila Velha, ES, Brazil. Anti-HAV were investigated by ELISA method serum 606 (four to fourteen years old) three schools, located neighborhoods with varying household monthly income levels: São José School, 200 children, higher than US$700; Torquato 273 US$200 300; and Cobi 133 less US$200. From each data on age, gender, skin color, sanitary conditions, frequency contact sea or river...
Objectives: To evaluate serum level of contractile protein troponin I (cTnI) within the 24 hrs sepsis and septic shock diagnosis in children to correlate with outcome (discharge from hospital or death). Design: Prospective, observational study. Setting: Pediatric Intensive Care Unit, at Hospital Infantil Nossa Senhora da Glória, Vitória, ES, Brazil. Patients: Two hundred eighteen consecutive admissions patients. Interventions: None. Measurements main results: Measurement cTnI (IMMULITE...
INTRODUCTION: The aim of this study was to evaluate the frequency anti-Toxocara antibodies in serum from 7-year-old children attending elementary school Vitória-ES, Brazil and correlate these with socio-demographic factors, presence intestinal helminths, blood eosinophil numbers, past history allergy or asthma, clinical manifestations helminth infections. METHODS: detection performed using an ELISA (Cellabs Pty Ltd)on 391 who had already been examined by fecal examination cell counts. Data...
The Scorpaena plumieri fish venom induces a severe pain and edema, observed both clinically experimentally. In order to understand more about the envenomation syndrome, present study characterized experimentally local acute inflammatory response induced by S. (SpV) in mouse model of tissue injury. Our results demonstrated that provoked after 2 h SpV injection footpad mice is release pivotal pro-inflammatory mediators (TNF, IL-6 MCP-1). These could be associated with histopathological changes...
In the streets of Vitória, in State Espírito Santo, Brazil, are large number stray dogs, many which infected with Toxocara canis, suggesting a high risk for human infection. order to investigate prevalence infection children Santo we studied anti-Toxocara antibodies 100 random inpatients over one year age, at Children's Hospital N.S. da Glória, reference children's hospital State.All sera were collected during period between October 1996 and January 1997. The mean age was 6.6±4.1 yrs. (1 14...
We report the results of a retrospective study on frequency intestinal nematodes among 198 alcoholic and 440 nonalcoholic patients at University Hospital Cassiano Antonio Moraes in Vit ria, ES, Brazil. The control sample included 194 matched according to age, sex neighborhood random 296 adults admitted same hospital. Stool examination by sedimentation method (three samples) was performed all patients. There significantly higher alcoholics than controls (35.3% 19.2%, respectively), due...
The prevalence and age distribution of Epstein-Barr virus infection varies in different populations there is little information about the epidemiology this Brazil. We studied EBV antibodies a sample 283 children adolescents between 1 21 years old. was taken from two neighborhoods Vitória (capital city Espirito Santo, Brazil). São Pedro (SP) neighborhood represented an area with lower socioeconomic status Praias (P) higher SES. Anti-VCA (Virus Capsid Antigen) were detected by ELISA anti-EBNA...
Journal Article A, B, O blood groups and hepatosplenic form of schistosomiasis mansoni (Symmer's fibrosis) Get access Fausto Edmundo Lima Pereira, Pereira Department de Biologia, Universidade Federal do Espírito Santo, C.P. 780, 29000 Vitória, Brasil Search for other works by this author on: Oxford Academic PubMed Google Scholar Eliete Rabbi Bortolini, Bortolini Joāo Luis Aquino Carneiro, Carneiro Carlos Rogério, Rogério Mello da Silva, Silva Ricardo Neves Transactions The Royal Society...
Background Symptomatic acute schistosomiasis mansoni is a systemic hypersensitivity reaction against the migrating schistosomula and mature eggs after primary infection. The mechanisms involved in pathogenesis of are not fully elucidated. Osteopontin has been implicated granulomatous reactions hepatic injury. Our aims were to evaluate if osteopontin plays role Schistosoma infection both human experimentally infected mice circulating OPN levels could be novel biomarker this...
OPN (osteopontin)) is a Hh (Hedgehog)-regulated cytokine that up-regulated during chronic liver injury and directly promotes fibrosis. We have reported signalling enhances viral permissiveness replication in HCV (hepatitis C virus)-infected cells. Hence we hypothesized replication, targeting could be beneficial HCV. In the present study, compared expression of mRNA protein (JFH1)-infected Huh7 Huh7.5 cells, evaluated whether modulating levels using exogenous ligands (up-regulate OPN) or...
SUMMARY Obesity is the main causal factor for metabolic syndrome and chronic systemic inflammation, which impacts on immune function increases susceptibility to pathogens. Here, we investigated effect of obesity outcome visceral leishmaniasis caused by Leishmaniasis infantum chagasi . C57BL/6 mice fed with high-sugar butter diet (HSB) showed a significant increase in body weight, adiposity index morphological changes adipocyte. To investigate consequences specific immunity against...