A5045529956- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Stress Responses and Cortisol
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Epilepsy research and treatment
- Regulation of Appetite and Obesity
- Protein Kinase Regulation and GTPase Signaling
- Nuclear Receptors and Signaling
- Neuroscience and Neural Engineering
- Toxic Organic Pollutants Impact
- Nerve injury and regeneration
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Autism Spectrum Disorder Research
University Medical Center Utrecht
2011-2024
Utrecht University
2000-2022
Hersenstichting
2018
Heidelberg University
2013
University Hospital Heidelberg
2013
University of Amsterdam
2008-2012
East China University of Science and Technology
2008
Netherlands Institute for Neuroscience
2004
University of Oslo
2001-2002
Maternal licking and grooming (LG) in infancy influences stress responsiveness cognitive performance the offspring. We examined effects of variation frequency pup LG on morphological, electrophysiological, behavioral aspects hippocampal synaptic plasticity under basal stress-like conditions. found shorter dendritic branch length lower spine density CA1 cells from adult offspring low compared with high also observed dramatic long-term potentiation (LTP) depending corticosterone treatment. Low...
Moderate impairment of learning and memory has been recognized as a complication diabetes. The present study examined behavioral electrophysiological measures cerebral function in streptozotocin (STZ)-induced diabetic rats. Behavioral testing consisted spatial task water maze. Electrophysiological vitro assessment hippocampal long-term potentiation (LTP), an activity-dependent form synaptic plasticity, which is believed to be related the cellular mechanisms memory. Two experiments were...
Abstract Insulin and its receptor are both present in the central nervous system implicated neuronal survival hippocampal synaptic plasticity. Here we show that insulin activates phosphatidylinositol 3‐kinase (PI3K) protein kinase B (PKB), results an induction of long‐term depression (LTD) CA1 neurones. Evaluation frequency–response curve plasticity revealed induced LTD at 0.033 Hz LTP 10 Hz, whereas absence insulin, 1 100 LTP. presence required low frequency stimulation (0.033 Hz) blockade...
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived factor (GDNF) and brain-derived (BDNF) may determine whether the resist or succumb to neurodegeneration. GDNF has been tested in clinical trials for treatment Parkinson disease (PD), a common neurodegenerative disorder characterized loss midbrain dopaminergic (DA) neurons. BDNF modulates nigrostriatal functions rescues DA PD animal models. The physiological roles signaling adult system are unknown....
Voltage-gated ion channels in the dendrites and somata of central neurons can modulate impact synaptic inputs. One ionic currents contributing to such modulation is fast inactivating A-type potassium current ( I A ). We have investigated role integration rat CA1 pyramidal cells by using arachidonic acid (AA) heteropodatoxin-3 (HpTX3), a selective blocker Kv4 underlying much somatodendritic . AA HpTX3 each reduced 60–70% (measured at soma) strongly enhanced amplitude summation excitatory...
The homeobox transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic neurons in a cell-autonomous gene-dose-dependent manner. Because this requirement, cells die by apoptosis when all four alleles Engrailed genes genetically ablated (En1-/-;En2-/-). In present study, we show that viable fertile mice, heterozygous null homozygous (En1+/-;En2-/-), have an adult phenotype resembles key pathological features Parkinson's disease. Specifically,...
Increasing environmental levels of brominated flame retardants raise concern about possible adverse effects, particularly through early developmental exposure.The objective this research was to investigate neurodevelopmental mechanisms underlying previously observed behavioral impairments after neonatal exposure polybrominated diphenyl ethers (PBDEs).C57Bl/6 mice received a single oral dose 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on postnatal day (PND) 10 (i.e., during the brain growth...
The rewarding value of palatable foods contributes to overconsumption, even in satiated subjects. Midbrain dopaminergic activity response reward-predicting environmental stimuli drives reward-seeking and motivated behavior for food rewards. This mesolimbic dopamine (DA) system is sensitive changes energy balance, yet it has thus far not been established whether reward signaling DA neurons vivo under control hormones that signal appetite balance such as ghrelin leptin. We trained rats (n=11)...
In animal models of diabetes mellitus, such as the streptozotocin-diabetic rat (STZ-rat), spatial learning impairments develop in parallel with a reduced expression long-term potentiation (LTP) and enhanced depression (LTD) hippocampus. This study examined time course effects STZ-diabetes insulin treatment on hippocampal post-synaptic glutamate N-methyl-D-aspartate (NMDA) receptor complex other key proteins regulating synaptic transmission density (PSD) fraction. addition, functional...
The phosphorylation state of two identified neural-specific protein kinase C substrates (the presynaptic B-50 and the postsynaptic neurogranin) was monitored after induction long term potentiation in CA1 field rat hippocampus slices by quantitative immunoprecipitation following 32Pi labeling recording chamber. increased from 10 to 60 min, but no longer at 90 min had been induced, neurogranin only min. Increased not found when blocked with N-methyl-D-aspartate receptor antagonist...
Abstract Memory impairments, which occur regularly across species as a result of ageing, disease (such diabetes mellitus) and psychological insults, constitute useful area for investigating the neurobiological basis learning memory. Previous studies in rats found that induction (with streptozotocin, STZ) impairs long‐term potentiation (LTP) but enhances depression (LTD) induced by high‐ (HFS) low‐frequency stimulations (LFS), respectively. Using pairing protocol under whole‐cell recording...
Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that catalyzes mono- and dimethylation of H3 lysine 9, thereby epigenetically regulating transcription. Kleefstra syndrome (KS), caused by haploinsufficiency the EHMT1 gene, an example emerging group intellectual disability (ID) disorders genes encoding epigenetic regulators neuronal gene activity. Little known about mechanisms underlying this disorder, prompting us to study heterozygous knockout (Ehmt1+/−) mice as...
μ-Opioid receptors (MORs) in the ventral tegmental area (VTA) are pivotally involved addictive behavior. While MORs typically activated by opioids, they can also become constitutively active absence of any agonist. In current study, we present evidence that MOR constitutive activity is highly relevant mouse VTA, as it regulates GABAergic input to dopamine neurons. Specifically, suppression with inverse agonist KC-2-009 enhanced neurotransmission onto VTA This agonistic effect was fully...
1 Whole cell recordings from CA1 pyramidal cells were performed to investigate the interaction between excitatory postsynaptic potentials (EPSPs) or currents (EPSCs), and slow Ca2+-dependent K+ current, IsAHP. Blockers of afterhyperpolarization (sAHP) such as isoprenaline (ISO) noradrenaline (NA) reduced hyperpolarization that followed a short train EPSPs, slowed decay summated EPSPs EPSCs. 2 ISO/NA action on synaptic responses was observed in absence potentials, but curtailed by Ca2+...
Abstract Synthetic corticosteroids, such as dexamethasone, are frequently administered to pregnant women at risk for preterm delivery. Endogenous corticosteroids essential normal development, but exposure therapeutic doses critical developmental stages may have adverse effects on the central nervous system. Major concern has arisen about long‐term of corticosteroid treatment brain plasticity, particularly in hippocampus. Therefore, we analyzed molecular, cellular, and behavioral prenatal...