A5084469418- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced Nanomaterials in Catalysis
- Porphyrin and Phthalocyanine Chemistry
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Ferrocene Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Photodynamic Therapy Research Studies
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Photoacoustic and Ultrasonic Imaging
- Sulfur Compounds in Biology
- Advanced Fluorescence Microscopy Techniques
- Cancer, Hypoxia, and Metabolism
- Molecular Junctions and Nanostructures
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Synthesis and bioactivity of alkaloids
- RNA Interference and Gene Delivery
- Organic Light-Emitting Diodes Research
University of Nottingham
2024
The Francis Crick Institute
2023-2024
Sun Yat-sen University
2017-2021
University of Birmingham
2014-2019
The Edgbaston Hospital
2017
Immunogenic cell death (ICD) is a vital component of therapeutically induced anti-tumor immunity. An iridium(III) complex (Ir1), containing an N,N-bis(2-chloroethyl)-azane derivate, as endoplasmic reticulum-localized ICD inducer for non-small lung cancer (NSCLC) reported. The characteristic discharge damage-associated molecular patterns (DAMPs), that is, surface exposure calreticulin (CRT), extracellular exclusion high mobility group box 1 (HMGB1), and ATP, were generated by Ir1 in A549...
Significance Photodynamic therapy is a noninvasive medical procedure in which malignant tissue damaged by reactive oxygen species generated from targeted light irradiation on photosensitizer. Herein, we incorporate an Ru(II)-based two-photon photosensitizer into macrocyclic structure via coordination-driven self-assembly. Properties favorable for photodynamic arise upon formation of the metallacycle, including near-infrared luminescence, strong absorption, high generation efficiency, and...
Photodynamic therapy (PDT) is a treatment procedure that relies on cytotoxic reactive oxygen species (ROS) generated by the light activation of photosensitizer. The photophysical and biological properties photosensitizers are vital for therapeutic outcome PDT. In this work 2D rhomboidal metallacycle 3D octahedral metallacage were designed synthesized via coordination-driven self-assembly Ru(II)-based photosensitizer complementary Pt(II)-based building blocks. showed deep-red luminescence,...
The efficacy of photodynamic therapy is typically reliant on the local concentration and diffusion oxygen. Due to hypoxic microenvironment found in solid tumors, oxygen-independent photosensitizers are great demand for cancer therapy. We herein report an iridium(III) anthraquinone complex as a mitochondrion-localized carbon-radical initiator. Its emission turned under conditions after reduction by reductase. Furthermore, its two-photon excitation properties (λex =730 nm) highly desirable...
A series of mitochondria-targeting cyclometalated iridium(<sc>iii</sc>) complexes activated the oncosis-specific protein porimin and calpain 1, exhibited good inhibitory activities on a wide range cancer types including drug-resistant cancers.
Oxidative stress induced by reactive oxygen species (ROS) is one of the major pathological mechanisms acute kidney injury (AKI). Inorganic nanomaterial-mediated antioxidant therapy considered a promising method for prevention AKI; however, currently available antioxidants AKI exhibit limited clinical efficacy due to glomerular filtration threshold (∼6 nm). To address this issue, we developed ultrasmall RuO2 nanoparticles (RuO2NPs) (average size ≈ 2 The NPs show excellent activity and low...
Compared to 2PE (two-photon excitation) microscopy, 3PE microscopy has superior spatial resolution, deeper tissue penetration, and less defocused interference. The design of suitable agents with a large Stokes shift, good three-photon absorption (3PA), subcellular targeting, fluorescence lifetime imaging (FLIM) properties, is challenging. Now, two IrIII complexes (3PAIr1 3PAIr2) were developed as efficient phosphorescence (3PP) agents. Calculations reveal that the introduction new group...
Abstract Reported is the Fe III ‐activated lysosome‐targeting prodrug FerriIridium for gastric cancer theranostics. It contains a meta ‐imino catechol group that can selectively bond to, and be oxidized by, free inside cell. Subsequent oxidative rearrangement releases II hydrolyses amine under acidic conditions, forming an aminobipyridyl Ir complex 2‐hydroxybenzoquinone. Thus, catalyzes Fenton reaction, transforming hydrogen peroxide into hydroxyl radicals, benzoquinone compounds interfere...
Inducing necroptosis in cancer cells is an effective approach to circumvent drug-resistance. Metal-based triggers have, however, rarely been reported. Ruthenium(II) complexes containing 1,1-(pyrazin-2-yl)pyreno[4,5-e][1,2,4]triazine were developed with a series of different ancillary ligands (Ru1-7). The combination the main ligand bipyridyl and phenylpyridyl endows Ru7 superior nucleus-targeting properties. As rare dual catalytic inhibitor, effectively inhibits endogenous activities...
A mitochondria-targeting hetero-binuclear complex (<bold>Ir–Ru</bold>) was developed for the synergistic photoactivated chemotherapy and photodynamic therapy of cisplatin-resistant tumour cells.
Nitric oxide (NO) and superoxide anions (O2•-) are two noteworthy reactive species implicated in various physiological pathological processes, such as ROS-induced lysosomal cell death. The interaction ("crosstalk") between them may form a new mediator peroxynitrite (ONOO–) which has implications for cancer, diabetes, Alzheimer's disease, liver-damage. It is therefore essential to investigate NO/O2•- crosstalk vivo through ONOO–-responsive molecular tools order fully comprehend the mechanisms...
New fluorine-free iridium complexes were synthesized in the aim of improving performance blue-green emitting LEECs.
A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this effective against cisplatin-resistant tumor cells. Mechanism experiments showed it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.
Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(ii) complex as photosensitizer (denoted Ru-Biotin). Ru-Biotin can selectively target and produce vast amounts singlet oxygen under two-photon excitation at 820 nm leading cell apoptosis. is therefore an excellent candidate overcome platinum resistance via photodynamic therapy.
The synthesis, structural and photophysical characterisation, LEEC devices of four novel, cationic iridium(<sc>iii</sc>) complexes are reported.
The organometallic anthraquinone iridium(<sc>iii</sc>) complexes display an efficient turn-on phosphorescence response to hypoxia. can induce cell apoptosis in HeLa cells <italic>via</italic> mitochondrial dysfunction and caspase-3 activation making them excellent candidates as theranostic agents for hypoxic cancer cells.