A5084297413- Skin Protection and Aging
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Psoriasis: Treatment and Pathogenesis
- Medical Imaging Techniques and Applications
- Inhalation and Respiratory Drug Delivery
- Medical Imaging and Pathology Studies
- Dermatology and Skin Diseases
- Radiomics and Machine Learning in Medical Imaging
- Dental Education, Practice, Research
- Radiation Dose and Imaging
- Parkinson's Disease Mechanisms and Treatments
- Advanced X-ray and CT Imaging
- Cutaneous Melanoma Detection and Management
- Contact Dermatitis and Allergies
- Innovations in Medical Education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA regulation and disease
- Allergic Rhinitis and Sensitization
- Radiology practices and education
- Cerebrovascular and genetic disorders
- Amyotrophic Lateral Sclerosis Research
- Neurological and metabolic disorders
- Ultrasound in Clinical Applications
- Radiopharmaceutical Chemistry and Applications
Coventry University
2022
Newcastle University
2008-2019
Royal Victoria Infirmary
1998-2019
Newcastle upon Tyne Hospitals NHS Foundation Trust
2011-2019
Newcastle Hospitals - Campus for Ageing and Vitality
2019
Newcastle Dental Hospital
2009
University of Newcastle Australia
2009
British Nuclear Medicine Society
2004-2006
Rotherham General Hospital
2005
St Thomas' Hospital
2005
<h3>OBJECTIVES</h3> The diagnosis of Alzheimer's disease (AD) is now reliant on the use NINCDS-ADRDA criteria. Other diseases causing dementia are being increasingly recognised—for example, frontotemporal (FTD). Historically, these disorders have not been clearly demarcated from AD. This study assesses capability criteria to accurately distinguish AD FTD in a series pathologically proved cases. <h3>METHODS</h3> case records 56 patients (30 with AD, 26 FTD) who had undergone...
Summary These guidelines for use of narrowband (TL‐01) ultraviolet B have been prepared dermatologists by the British Photodermatology Group on behalf Association Dermatologists. They present evidence‐based guidance treatment patients with a variety dermatoses and photodermatoses, identification strength evidence available at time preparation guidelines, brief overview background photobiology.
The purpose of this study was to examine the possible association between "classic" motor neuron disease (cMND) and frontotemporal dementia (FTD), using neuropsychological evaluation single photon emission computed tomography (SPECT). Psychological tests assessing language, perceptuospatial, memory, "frontal lobe" functions were given patients with cMND test scores compared those normal control subjects. 99mTc-HMPAO SPECT performed on cMND, FTD (FTD/MND), alone, Regional cerebral blood flow...
<h3>OBJECTIVES</h3> To provide the clinician with a guide to clinical utility of <sup>99m</sup>Tc-HMPAO single photon emission computed tomography (SPECT) and interpretation specific test results in differential diagnosis dementia. <h3>METHODS</h3> Three hundred sixty three patients dementia were studied prospectively for median (range 1–6) years classified into disease groups on basis established criteria. The degree which different patterns cerebral blood flow (CBF) abnormality found...
Alzheimer's disease (AD), frontotemporal dementia (FTD) and vascular (VaD) are the three most common causes of young onset dementias. Most neuroimaging studies these disorders have involved comparisons with normal controls. The aims this study were to examine clinical diagnostic value magnetic resonance imaging (MRI) single photon emission computed tomography (SPECT) (in combination in isolation) differentiation one form from another amongst a group AD, FTD VaD.T1 weighted MRI images...
Photopheresis or extracorporeal photochemotherapy (ECP) is a novel immunomodulatory therapy which involves separation of the patient's leucocyte-rich plasma, followed by ex vivo administration photosensitizer and ultraviolet A radiation, before reinfusion. ECP has been used successfully for treatment cutaneous T-cell lymphoma (CTCL: Sézary syndrome), graft-versus-host disease (GVHD) cardiac transplant rejection. dose-sparing effect on concurrent immunosuppressive therapy. The procedure...
Psoriasis is a common chronic skin disorder, but the mechanisms involved in resolution and clearance of plaques remain poorly defined. We investigated mechanism action UVB, which highly effective clearing psoriasis inducing remission, tested hypothesis that apoptosis key mechanism. To distinguish bystander effects, equal erythemal doses two UVB wavelengths were compared following vivo irradiation psoriatic plaques; one clinically (311 nm) has no therapeutic effect on (290 nm). Only 311 nm...
Skin imaging devices to aid melanoma diagnosis have been developed in recent years but few assessed clinically.To investigate if a spectrophotometric skin device, the SIAscope, could increase dermatologist's ability distinguish from nonmelanoma screening clinic.Eight hundred and eighty-one pigmented lesions 860 patients were prospectively clinically with of device by dermatologist. Assessment before after was made compared histology, where available, or clinical dermatologist 20...
Summary This report examines the dosimetry of ultraviolet (UV) radiation applied to dermatological treatments, and considers definition quantities their measurement. Guidelines are offered for preferred measurement techniques standard methods dosimetry. The recommendations have been graded according American Joint Committee on Cancer classification strength recommendation quality evidence (summarized in Appendix 5).
Dementia with Lewy bodies (DLB) is the second commonest neurodegenerative cause of dementia. While there consensus on clinical diagnostic criteria for DLB, use EEG to increase sensitivity has not been substantiated.We studied resting findings in 18 consecutive patients DLB and compared them a control group 20 "probable" Alzheimer's disease (AD). We aimed evaluate representative sample DLB.All fulfilled accepted DLB. The had more severe dementia than AD group, as measured by Mini-Mental State...
The nuclear factor of activated T cells (NFAT) transcription factors are regulated by calcium/calcineurin signals and play important roles in cells, muscle, bone, neural tissue. NFAT is expressed the epidermis, although recent data suggest that involved skin's responses to ultraviolet radiation (UVR), wavelengths activate biological function UV- remain undefined. We demonstrate transcriptional activity preferentially induced UVB keratinocytes. derived action spectrum for activation indicates...
Abstract Background: Imagery rescripting (IR) is an effective intervention for social anxiety disorder (SAD) that targets memories of distressing formative events linked to negative self-imagery (NSI). IR thought update unhelpful schema by addressing the needs younger self within memory. An accumulating body evidence indicates modifying NSI, can significantly affect imagery, memory appraisal, and beliefs about self. Aims: This systematic review aims critically evaluate synthesise literature...
Hand eczema is a common inflammatory dermatosis that causes significant patient morbidity. Previous studies comparing psoralen–ultraviolet A (PUVA) with narrowband ultraviolet B (NB‐UVB) have been small, nonrandomized and retrospective. To conduct an observer‐blinded randomized controlled pilot study using validated scoring criteria to compare immersion PUVA NB‐UVB for the treatment of chronic hand unresponsive topical steroids. Sixty patients clobetasol propionate 0·05% were receive either...
The occurrence of high signal abnormalities on T2 weighted images is strongly age related. diagnostic value these changes in a younger population with dementia not currently known. We studied the potential magnetic resonance imaging (MRI) differentiating Alzheimer's disease (AD), frontotemporal (FTD) and vascular (VaD) patients.High were rated, using previously validated scale, from hard copies axial 102 patients AD (n=49), VaD (n=31), FTD (n=22) (mean ages 63-65 years).High widespread...
Abstract Krypton-81m gas, by virtue of its imaging characteristics, is often considered the “gold standard” for ventilation scintigraphy but use restricted high cost and limited availability. The new radiopharmaceutical 99Tcm-Technegas, a suspension ultrafine technetium-99m labelled carbon particles, produces high-quality images has advantage continuous As part our evaluation Technegas two were compared in 40 patients with variety established respiratory diseases. Disparities seen five...
Photosensitive patients sometimes report disease flares during journeys by car. Window glass blocks all UVB but not UVA. All car windscreens are made from laminated glass. Side and rear windows usually of nonlaminated glass.To determine which types provide most protection UVA with particular reference to the implications for polymorphic light eruption (PLE).The percentage transmission was determined a selection glass, both nonlaminated, differing colour tints.Laminated transmits less than...
The aim of this work was to develop the first north-east based primary dental care outreach (PDCO) course for clinical undergraduate students at Newcastle University. process design will be described and involved review existing Bachelor Dental Surgery (BDS) degree in relation previously published learning outcomes. Areas were identified where BDS did not meet fully these This followed by setting PDCO aims objectives, intended outcomes, curriculum structure. educational strategy methods...
Journal Article Provocation testing in polymorphic light eruption using fluorescent ultraviolet (UV) A and UVB lamps Get access S. Das, Das Department of Dermatology Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, U.K Search for other works by this author on: Oxford Academic Google Scholar J.J. Lloyd, Lloyd D. Walshaw, Walshaw Statistics, University P.M. Farr Professor P. M. Farr. E‐mail: peter.farr@ncl.ac.uk British Dermatology, Volume 151, Issue...