A5016092134- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Tryptophan and brain disorders
- Alkaline Phosphatase Research Studies
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Polyamine Metabolism and Applications
- Neuroendocrine Tumor Research Advances
- Glycosylation and Glycoproteins Research
- FOXO transcription factor regulation
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Gut microbiota and health
- vaccines and immunoinformatics approaches
- Family Support in Illness
The University of Texas MD Anderson Cancer Center
2022-2025
Centro Medico Nacional Siglo XXI
2019-2021
Mexican Social Security Institute
2020-2021
Hospital de Especialidades
2019-2021
Universidad Nacional Autónoma de México
2019-2020
The nuclear factor erythroid 2-related 2 (NRF2) pathway is frequently activated in various cancer types. Aberrant activation of NRF2 attributed to gain-of-function mutations the NRF2-encoding gene NFE2L2 or a loss function its suppressor, Kelch-like ECH-associated protein 1 (KEAP1). exerts pro-tumoral effects part by altering cell metabolism. Previously, we reported novel mechanism tumoral immune suppression through selective upregulation tryptophan-metabolizing enzyme kynureninase (KYNU)...
Abstract Purpose: We conducted metabolomics and spatial cell transcriptomics of intraductal papillary mucinous neoplasms (IPMN), recognized pancreatic cancer precursors, to identify oncometabolites that inform upon risk malignancy IPMN. Experimental Design: Untargeted metabolomic analyses were performed on cystic fluid from 125 patients with low-grade dysplasia (LG) or high-grade (HG) with/without concurrent PDAC (IPMN/PDAC). Predictive performance individual metabolites for identifying HG...
Immunotherapy has improved the clinical response in melanoma patients, although a relevant percentage of patients still cannot be salvaged. The search for immune populations that provide best tumor control and can coaxed by immunotherapy strategies is hot topic cancer research nowadays. Tumor-infiltrating TCF-1+ progenitor exhausted CD8+ T cells seem to grant prognosis also efficiently respond anti-PD-1 immunotherapy, giving rise TIM-3+ terminally population with heightened effector...
HPV E5 is an oncoprotein mainly expressed in premalignant lesions, which makes it important target for a vaccine to prevent or cure cervical cancer (CC). In this study, we evaluated whether targeted DEC-205, present dendritic cells (DCs), could induce therapeutic protection against HPV16-induced tumor mouse model. The HPV-16 (16E5) protein was cross-linked monoclonal antibody (mAb) specific DEC-205 (anti-DEC-205:16E5) isotype control mAb (isotype:16E5). Rotavirus VP6 the anti-DEC-205...
SUMMARY Selective autophagy of mitochondria is known to promote survival and progression cancer cells in various malignancies including triple-negative breast (TNBC). Here, we aimed identify the essential metabolic adaptations that support mitochondrial quality control with goal uncover actionable vulnerabilities therapeutic potential. Using an integrated approach proteomics untargeted stable-isotope resolved metabolomics, coupled functional experimental analyses, define alternative...
The development of diverse spatial profiling technologies has provided an unprecedented insight into molecular mechanisms driving cancer pathogenesis. Here, we conducted the first integrated cross-species assessment transcriptomics and metabolomics alterations associated with progression intraductal papillary mucinous neoplasms (IPMN), bona fide cystic precursors pancreatic ductal adenocarcinoma (PDAC).Matrix Assisted Laster Desorption/Ionization (MALDI) mass spectrometry (MS)-based imaging...
Abstract Purpose: To define the metabolic alterations associated with malignant progression of intraductal papillary mucinous neoplasm (IPMN). Experimental Procedures: Matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) was conducted for spatial characterization lipid profiles on frozen tissue sections from resected human IPMN patients. The specimen set consisted either low-grade dysplasia (LG) (n=15), high-grade (HG) (n=4), or an pancreatic ductal adenocarcinoma...
Abstract The existence of asymptomatic precursor lesions that are known to predate invasive pancreatic ductal adenocarcinoma (PDAC) by years provides a compelling rationale for cancer interception efforts. One such is intraductal papillary mucinous neoplasm (IPMN). Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) imaging metabolites in tissue sections from resected patient IPMN cases (N=23) and KrasG12D/GnasR201C mouse model IPMN, we have made discovery long...
Abstract Emerging evidence suggests that cancer cells can mimic features of immune during oncogenic transformation to drive disease progression. We assessed the occurrence immunological markers in breast determine their expression pattern. initially analyzed 18 protein (CCR4, CCR6, CCR7, CD11, CD123, CD14, CD16, CD19, CD24, CD25, CD27, CD3, CD38, CD4, CD45, CD56, CD8 and CXCR3) expressed on surface 28 cell lines using mass spectrometry. CD14 tumor its association with clinical outcomes was...
Abstract Alkaline phosphatase placental type (ALPP) and ALPPL2 are closely related regulated GPI anchored proteins that known to be expressed on the cell surface in some cancers, whereas normal tissue expression is largely limited placenta. Clinical utility of ALPP potentially by heterogenous tumors. Here, we assessed surfaceome protein levels 158 cancer lines mRNA 10,967 tumors representing 32 types from The Cancer Genome Atlas (TCGA), which revealed ALPP, a lesser extent ALPPL2, variably...
e15018 Background: In normal tissues placental alkaline phosphatases (ALPP) and ALPPL2 are exclusively expressed in the placenta. Their discovery cancer surfaceome has opened possibility of targeting ALPP/ALPPL2. However, their low expression most types limits therapeutic potential. this study, we report a novel mechanism ALPP upregulation cells that renders these more susceptible to ALPP-targeting therapies, which evidence context lung adenocarcinoma. Methods: Surface was determined...
Abstract Expression levels of placental alkaline phosphatase (ALPP) and ALPP-like 2 (ALPPL2) are relatively low in most cancer types, limiting potential benefits from ALPP or ALPPL2 targeting therapies. Enhancing their expression would be an attractive approach for targeted therapy. We have undertaken analysis protein whole cell extracts (WCE) the surfaceome 158 lines found ALPP, to a less extent ALPPL2, expressed on surface at across multiple types. explored various means enhance lung...
Abstract Comprehensive proteomic profiling of plasmas collected before and after neo-adjuvant treatment for gastric cancer (GC) yielded 522 proteins exhibiting higher pre-treatment levels compared to healthy controls among them, 345 decreased the treatment. Increased cytoskeleton-related were manifest in GC patients. Cytoskeletal are known play integral roles modulating epithelial plasticity by altering mechanical strength structural design that is critical cell motility, mesenchymal...