A5092630338- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Neurological Complications and Syndromes
- Cardiovascular Issues in Pregnancy
- Single-cell and spatial transcriptomics
- Aldose Reductase and Taurine
- Reproductive System and Pregnancy
- Receptor Mechanisms and Signaling
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal and fetal healthcare
Technion – Israel Institute of Technology
2023-2024
Abstract The amygdala is a brain region primarily associated with emotional response. use of genetic markers and single-cell transcriptomics can provide insights into behavior-associated cell state changes. Here we present detailed cell-type taxonomy the adult mouse during fear learning memory consolidation. We perform RNA sequencing on naïve fear-conditioned mice, identify 130 neuronal types validate their spatial distributions. A subset all transcriptionally responsive to retrieval....
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute both diseases, suggesting a common underlying pathophysiological process. However, what drives this process remains unclear. Using serum proteomics, we identified the senescence-associated secretory phenotype (SASP), marker cellular senescence biological aging, as most highly up-regulated pathway young women...
Preeclampsia is a multisystemic, pregnancy-specific disorder united by new-onset hypertension but with considerable variation in clinical manifestation, onset, and severity. For symptoms to regress, delivery of the placenta required. required, making central preeclampsia pathophysiology. To dissect which placental functions were impacted two forms preeclampsia, we studied molecular changes across cell types placenta.We performed transcriptomic survey single-cells single-nuclei on cases...