A5080771795- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Fungal Biology and Applications
- Plant Toxicity and Pharmacological Properties
- Plant-based Medicinal Research
- X-ray Diffraction in Crystallography
- Bioactive Natural Diterpenoids Research
- Crystallization and Solubility Studies
- Ethnobotanical and Medicinal Plants Studies
- Sesquiterpenes and Asteraceae Studies
- Essential Oils and Antimicrobial Activity
- Moringa oleifera research and applications
- Analytical Chemistry and Sensors
- Traditional Chinese Medicine Analysis
- Traditional and Medicinal Uses of Annonaceae
- Heavy Metals in Plants
- Microbial Natural Products and Biosynthesis
- Mycorrhizal Fungi and Plant Interactions
- Advanced Chemical Sensor Technologies
- Bee Products Chemical Analysis
- Medicinal plant effects and applications
- Food Quality and Safety Studies
- Alkaloids: synthesis and pharmacology
- Algal biology and biofuel production
University of Electronic Science and Technology of China
2014-2025
Scripps Research Institute
2018
Peking University
2006-2009
Sichuan University
2003-2008
West China Medical Center of Sichuan University
2003
Natural products offer unmatched chemical and structural diversity compared to other small-molecule libraries, but traditional natural product discovery programs are not sustainable, demanding too much time, effort, resources. Here we report a strain prioritization method for discovery. Central the is application of real-time PCR, targeting genes characteristic biosynthetic machinery with distinct scaffolds in high-throughput format. The practicality effectiveness were showcased by...
Hericium erinaceus, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of erinaceus led to isolation one new ergostane-type sterol fatty acid ester, erinarol K (1); eleven known compounds: 5α,8α -epidioxyergosta-6,22-dien-3β-yl linoleate (2); ethyl (3); linoleic (4); hericene A (5); D (6); E (7); ergosta-4,6,8(14),22-tetraen-3-one (8); hericenone F (9); ergosterol (10); peroxide (11);...
Tautomycetin (TTN) is a polyketide natural product featuring terminal alkene. Functional characterization of the genes within ttn gene cluster from Streptomyces griseochromogenes established biosynthesis TTN backbone, its dialkylmaleic anhydride moiety, coupling two moieties to form nascent intermediate F-1, and tailoring steps converting F-1 TTN. Here, we report biochemical structural TtnD, prenylated FMN (prFMN)-dependent decarboxylase belonging UbiD family that catalyzes penultimate step...
The essential oil from Phytolacca dodecandra, a traditional herb of Ethiopia, has been studied, including the chemical composition and antimicrobial activity. difference between four P. dodecandra samples (P-1⁻P-4), which differed in gender or location, also analyzed. oils were obtained by steam distillation, while aromas extracted head space solid-phase microextraction (HS-SPME) both analyzed gas chromatography- mass spectrometry (GC-MS). oils' activities evaluated microdilution method...
Morchella sextelata, one of the true morels, has recently been artificially cultivated with stable production in China. Analysis variations primary metabolites during vegetative stages M. sextelata is critical for understanding metabolic process. In this study, three developmental were categorized based on morphological and changes, including young mushroom period, marketable mature physiological maturity period. Untargeted metabolomics-based mass spectrometry was used to analyze change...
Morchella sextelata is an edible and medicinal fungus with high nutritional, medicinal, economic value. Recently, M. has been produced through artificial cultivation in China, but its stable production remains problematic because the details of growth development process are limitedly understood. Herein, to investigate dynamic development, we integrated transcriptomics metabolomics data from three developmental stages: young mushroom period (YMP), marketable mature (MMP), physiological...
Two new C 19 -diterpenoid alkaloids, liljestrandinine (1) and N-deethyltalatisamine (2) were isolated from the roots of Aconitum liljestrandii along with five known alkaloids: chasmaconitine (4), forestine (5), pengshenine B (6), cammaconine (7), 6-epi-foresticine (8).Structures established by spectroscopic method including 2D NMR.In course our comparative studies on diterpenoid alkaloids Delphinium species, 1~5 we investigated (Ranunculaceae). 6The plant is endemic to China its are used for...
A chiral tetralin norsesquiterpenoid, ligukangtinol, was isolated from the plant Ligularia kangtingensis. Its planar structure determined by extensive analysis of spectroscopic data (MS, IR, and NMR), (1S,3R) absolute configuration ring established TDDFT-ECD calculations solution conformers. Conformational ECD proved that semiempirical helicity rules 6-hydroxytetralins correlating (1)L(b) Cotton effect P/M fused carbocyclic correctly predicts thus can be used for configurational assignment...
The aconitine-type alkaloids talatisamine (1), 8,14-diacetyltalatisamine (11), and compound 3, the lycoctonine-type alkaloid deltaline (5), 7,17-seco C19-diterpenoid 7 9 were treated with HBr–glacial acetic acid to give useful O-demethylated derivatives 2, 4, 6, 8, 10 respectively in good high yields (49–90%).
Abstract Eight new triterpene saponins, ilexpernosides C–J ( 1 – 8 , resp.), and eight known saponins were isolated from the 70% EtOH extract of leaves Ilex pernyi. The structures compounds elucidated by spectroscopic data chemical degradation.
Ten triterpenoid glycosides, including five new ones (1—5), were isolated from the leaves of Ilex pernyi. The chemical structures 1—5 determined on basis and spectroscopic evidence.
Morels (Morchella spp.) are valuable medicinal and edible mushrooms. In this study, chemical profiles of aromas lipophilic extracts black morel importuna) grown in China were analyzed by gas chromatography/mass spectroscopy, along with the evaluation antioxidant antimicrobial activities for extracts. Sixty-five compounds total identified from aromas, 1-octen-3-ol was main component fresh (34.40%) freeze-dried (68.61%) morels, while most abundant compound aroma oven-dried sample...
Background: Justicia schimperiana is popularly used as folk medicines in Ethiopia.Objective: The chemical composition of essential oils from the leaves was analyzed and its antimicrobial activities were evaluated.Methods: oil obtained by steam distillation constituents separated identified GC-MS, using normalization method to calculated relative amount. Its evaluated micro dilution against Escherichia coli, Bacillus subtilis Candida albicans.Results: From , 28 compounds identified; making up...
The studies on the leaves of Acokanthera schimperi, a traditional herb Ethiopia, afforded eight triterpenoids, including new triterpenoid ester, lupan-20-ol-3()-yl 3-hydroxyoctadecanoate (1), along with seven known lupeol (2), 28-nor-urs-12-ene-3,17-diol (3), ursolic aldehyde (4), 3-hydroxyoleana-11,13(18)-dien-28-oic acid (5), alagidiol (6), oleanolic (7) and lactone (8).Their structures were determined by spectroscopic methods 2D NMR techniques X-ray diffraction analysis.
Abstract Two new phenolic glycosides, scolochinenosides A and B ( 1 2 ), a flavonoid glycoside, scoloside 3 were isolated from the leaves of Scolopia chinensis Lour .) Clos , together with eight known compounds. The structures compounds established on basis chemical spectroscopic evidences.
Pharmacognosy Magazine,2015,11,41,44-47.DOI:10.4103/0973-1296.149702Published:January 2015Type:Original ArticleAuthors:Jin Tian, Guang-Bo Xie, Ya and Tie-Nan Li Author(s) affiliations:Jin Department of Biotechnology, School Life Science Technology, University Electronic Technology China, Chengdu 610054, China Abstract:Background: Ligularia kangtingensis, a species from the genus (Compositae), is an indigenous plant in Southwest more than 20 this have been used as folk medicines China....
Abstract Ilexpernoside A and ilexpernoside B, two new pentacyclic C 4 ‐nortriterpenoid saponins, were isolated from the leaves of Ilex pernyi Franch. Their chemical structures determined by MS, NMR spectroscopy analysis. Complete assignments 1 H 13 spectroscopic data achieved 1D 2D experiments (HSQC, HMBC, H– COSY NOESY). Copyright © 2007 John Wiley & Sons, Ltd.
Sibiralactone (1), a new monoterpene derivative, was isolated from the leaves of Sibiraea angustata. The structure determined by analysis its NMR data and absolute configuration established TDDFT ECD calculation solution conformers.