Patrick T. Wedlock

ORCID: 0000-0001-7635-5949
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About
Contact & Profiles
Research Areas
  • Vaccine Coverage and Hesitancy
  • COVID-19 epidemiological studies
  • SARS-CoV-2 and COVID-19 Research
  • Viral gastroenteritis research and epidemiology
  • Hepatitis Viruses Studies and Epidemiology
  • Influenza Virus Research Studies
  • COVID-19 and healthcare impacts
  • Virology and Viral Diseases
  • Obesity, Physical Activity, Diet
  • Innovation and Socioeconomic Development
  • Child Nutrition and Feeding Issues
  • Physical Activity and Health
  • Opioid Use Disorder Treatment
  • HIV, Drug Use, Sexual Risk
  • Infection Control and Ventilation
  • Community Development and Social Impact
  • Homelessness and Social Issues
  • Quality and Safety in Healthcare
  • Trypanosoma species research and implications
  • Genetic Associations and Epidemiology
  • Physical Education and Pedagogy
  • Digital Mental Health Interventions
  • Research on Leishmaniasis Studies
  • Antimicrobial Resistance in Staphylococcus
  • Advancements in Transdermal Drug Delivery

City University of New York
2020-2022

The Graduate Center, CUNY
2020-2022

Johns Hopkins University
2016-2021

Columbia University
2021

Museum of Heilongjiang Province
2021

Health and Education Research Management and Epidemiologic Services (United States)
2016-2019

Face mask wearing has been an important part of the response to COVID-19 pandemic. As vaccination coverage progresses in countries, relaxation such practices is increasing. Subsequent surges have raised questions whether face masks should be encouraged or required and for how long. Here, we aim assess value maintaining use indoors according different levels USA.

10.1016/s2468-2667(22)00040-8 article EN cc-by The Lancet Public Health 2022-03-08

Increasing physical activity among children is a potentially important public health intervention. Quantifying the economic and effects of intervention would help decision makers understand its impact priority. Using computational simulation model that we developed to represent all US ages 8–11 years, estimated maintaining current levels (only 31.9 percent get twenty-five minutes high-calorie-burning three times week) result each year in net present value $1.1 trillion direct medical costs...

10.1377/hlthaff.2016.1315 article EN Health Affairs 2017-05-01

With multiple coronavirus disease 2019 (COVID-19) vaccines available, understanding the epidemiologic, clinical, and economic value of increasing coverage levels expediting vaccination is important.

10.1093/infdis/jiab233 article EN other-oa The Journal of Infectious Diseases 2021-04-28

Background As the Zika virus epidemic continues to spread internationally, countries such as United States must determine how much invest in prevention, control, and response. Fundamental these decisions is quantifying potential economic burden of under different scenarios. Methodology/Principle findings To inform decision making, our team developed a computational model forecast across six states US (Alabama, Florida, Georgia, Louisiana, Mississippi, Texas) which are at greatest risk...

10.1371/journal.pntd.0005531 article EN cc-by PLoS neglected tropical diseases 2017-04-27

While our previous work has shown that replacing existing vaccines with thermostable can relieve bottlenecks in vaccine supply chains and thus increase availability, the question remains whether this benefit would outweigh additional cost of formulations.Using HERMES simulation models for Republic Benin, state Bihar (India), Niger, we simulated different formulations determined resulting clinical economic impact. Costs measured included costs vaccines, logistics, disease outcomes...

10.1016/j.vaccine.2017.03.081 article EN cc-by Vaccine 2017-04-26

During an influenza epidemic, where early vaccination is crucial, pharmacies may be a resource to increase vaccine distribution reach and capacity. We utilized agent-based model of the US clinical economics outcomes simulate impact different epidemics utilizing in addition traditional (hospitals, clinic/physician offices, urgent care centers) locations for year 2017. For epidemic with reproductive rate (R0) 1.30, adding typical business hours averted 11.9 million symptomatic cases, 23,577...

10.1016/j.vaccine.2018.09.040 article EN cc-by Vaccine 2018-10-16

Finding medications or vaccines that may decrease the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could potentially reduce transmission in broader population. We developed a computational model U.S. simulating spread SARS-CoV-2 and potential clinical economic impact reducing duration. Simulation experiments found average duration avert median 442,852 [treating 25% symptomatic cases, by 0.5 days, reproductive number (R 0 ) 3.5, starting treatment when 15%...

10.1371/journal.pcbi.1008470 article EN cc-by PLoS Computational Biology 2021-01-07

<h3>Importance</h3> Multidrug-resistant organisms (MDROs) can spread across health care facilities in a region. Because of limited resources, certain interventions be implemented only some facilities; thus, decision-makers need to evaluate which may best implement. <h3>Objective</h3> To identify group target and assess MDRO intervention would implement the Shared Healthcare Intervention Eliminate Life-threatening Dissemination MDROs Orange County, large regional public collaborative...

10.1001/jamanetworkopen.2021.19212 article EN cc-by-nc-nd JAMA Network Open 2021-08-04

Gavi recommends solar refrigerators for vaccine storage in areas with less than eight hours of electricity per day, and WHO guidelines are more conservative. The question remains: Can provide value where electrical outages frequent?Using a HERMES-generated computational model the Mozambique routine immunization supply chain, we simulated use versus electric mains-powered (hereafter referred to as "electric refrigerators") at different locations chain under various circumstances.At their...

10.1016/j.vaccine.2016.11.103 article EN cc-by Vaccine 2017-03-30

Coping occurs when health system personnel must make additional, often undocumented efforts to compensate for existing and management deficiencies. While such may be done with good intentions, few studies evaluate the broader impact of coping.We developed a computational simulation model Bihar, India's routine immunisation supply chain where coping (ie, making additional vaccine shipments above stated policy) occurs. We simulated by allowing extra trips occur as needed up one time per day...

10.1136/bmjgh-2019-001609 article EN cc-by BMJ Global Health 2019-09-01

Abstract Background Given the continuing coronavirus disease 2019 (COVID-19) pandemic and much of U.S. implementing social distancing due to lack alternatives, there has been a push develop vaccine eliminate need for distancing. Methods In 2020, we developed computational model simulating spread COVID-19 vaccination. Results Simulation experiments revealed that when efficacy exceeded 70%, coverage 60%, vaccination occurred on day 1, attack rate dropped 22% with daily cases not exceeding 3.2...

10.1101/2020.05.29.20117184 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-05-30

Abstract Objective: Due to shortages of N95 respirators during the coronavirus disease 2019 (COVID-19) pandemic, it is necessary estimate number N95s required for healthcare workers (HCWs) inform manufacturing targets and resource allocation. Methods: We developed a model determine needed HCWs both in single acute-care hospital United States. Results: For an with 400 all-cause monthly admissions, manage COVID-19 patients admitted month ranges from 113 (95% interpercentile range [IPR],...

10.1017/ice.2020.1418 article EN cc-by Infection Control and Hospital Epidemiology 2021-01-11

By pairing diluent with vaccines, dual-chamber vaccine injection devices simplify the process of reconstituting vaccines before administration and thus decrease associated open vial wastage adverse events. However, since these are larger than current vials for lyophilized manufacturers need guidance as to how size may affect distribution delivery.Using HERMES-generated immunization supply chain models Benin, Bihar (India), Mozambique, we replace routine 10-dose measles-rubella (MR)...

10.1016/j.vaccine.2018.08.026 article EN cc-by Vaccine 2018-08-23

With norovirus vaccine candidates currently under development, now is the time to identify characteristics and implementation thresholds at which vaccination becomes cost effective saving in a community setting.In 2020, transmission, clinical, economics computational simulation model representing different U.S. population segments was developed simulate spread of potential impact vaccinating children aged <5 years older adults (aged ≥65 years).Compared with no vaccination, preschool-aged...

10.1016/j.amepre.2020.10.022 article EN cc-by American Journal of Preventive Medicine 2021-01-27
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