A5005013292- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Alcohol Consumption and Health Effects
- Thermal Regulation in Medicine
- Mesenchymal stem cell research
- Sulfur Compounds in Biology
- Traumatic Brain Injury and Neurovascular Disturbances
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Hydrogen's biological and therapeutic effects
Universidade Nova de Lisboa
2012-2021
Instituto de Biologia Experimental e Tecnológica
2010-2018
The present work demonstrates the ability of CO to prevent apoptosis in a primary culture astrocytes. For first time, antiapoptotic behavior can be clearly attributed inhibition mitochondrial membrane permeabilization (MMP), key event intrinsic apoptotic pathway. In isolated non-synaptic mitochondria, partially inhibits (i) loss potential, (ii) opening nonspecific pore through inner membrane, (iii) swelling, and (iv) cytochrome c release, which are induced by calcium, diamide, or...
Modulation of cerebral cell metabolism for improving the outcome hypoxia-ischemia and reperfusion is a strategy yet to be explored. Because carbon monoxide (CO) known prevent death; herein role CO in modulation astrocytic metabolism, particular, at level mitochondria was investigated. Low concentrations partially inhibited oxidative stress-induced apoptosis astrocytes, by preventing caspase-3 activation, mitochondrial potential depolarization, plasmatic membrane permeability. exposure...
MITOCHONDRIA PRESENT TWO KEY ROLES ON CELLULAR FUNCTIONING: (i) cell metabolism, being the main cellular source of energy and (ii) modulation death, by mitochondrial membrane permeabilization. Carbon monoxide (CO) is an endogenously produced gaseoustransmitter, which presents several biological functions involved in maintaining homeostasis cytoprotection. Herein, mitochondrion approached as target carbon (CO). In this paper, two perspectives concerning CO functioning are evaluated. First,...
Abstract Background Low concentrations of carbon monoxide (CO) protect hepatocytes against apoptosis and confers cytoprotection in several models liver. Mitochondria are key organelles cell death control via their membrane permeabilization the release pro-apoptotic factors. Results Herein, we show that CO prevents mitochondrial (MMP) liver isolated mitochondria. Direct indirect approaches were used to evaluate MMP inhibition by CO: swelling, depolarization inner permeabilization....
Cerebral ischemia and neurodegenerative diseases lead to impairment or death of neurons in the central nervous system. Stem cell based therapies are promising strategies currently under investigation. Carbon monoxide (CO) is an endogenous product heme degradation by oxygenase (HO) activity. Administration CO at low concentrations produces several beneficial effects distinct tissues, namely anti-apoptotic anti-inflammatory. Herein role on modulation neuronal differentiation was assessed....
Over the last decades, silent-killer carbon monoxide (CO) has been shown to also be an endogenous cytoprotective molecule able inhibit cell death and modulate mitochondrial metabolism. Neuronal metabolism is mostly oxidative neurons use glucose for maintaining their anti-oxidant status by generation of reduced glutathione (GSH) via pentose-phosphate pathway (PPP). It established that neuronal differentiation depends on reactive oxygen species (ROS) signalling, however there a lack...
Abstract The process of cell differentiation goes hand‐in‐hand with metabolic adaptations, which are needed to provide energy and new metabolites. Carbon monoxide ( CO ) is an endogenous cytoprotective molecule able inhibit death improve mitochondrial metabolism. Neuronal processes were studied using the NT 2 line, derived from human testicular embryonic teratocarcinoma differentiates into post‐mitotic neurons upon retinoic acid treatment. ‐releasing A1 CORM ‐A1) was used do deliver culture....
Exploratory studies using human fetal tissue have suggested that intrastriatal transplantation of dopaminergic neurons may become a future treatment for patients with Parkinson's disease. However, the use is compromised by ethical, regulatory and practical concerns. Human stem cells constitute an alternative source in disease, but efficient protocols controlled differentiation need to be developed. Short-term, low-level carbon monoxide (CO) exposure has been shown affect signaling several...
SpringerPlus 2015, 4(Suppl 1):L1 MicroRNAs (miRNAs) are short, 22-25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3'-untranslated region (3'-UTR) of coding mRNA targets, interrupting translation and inducing degradation these targets.The 3'-UTRs brain compared to other tissues predict important roles for miRNAs.Supporting this notion, we found miRNAs co-evolved their target transcripts, non-coding pseudogenes miRNA recognition elements...
SpringerPlus 2015, 4(Suppl 1):L1 MicroRNAs (miRNAs) are short, 22-25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3'-untranslated region (3'-UTR) of coding mRNA targets, interrupting translation and inducing degradation these targets.The 3'-UTRs brain compared to other tissues predict important roles for miRNAs.Supporting this notion, we found miRNAs co-evolved their target transcripts, non-coding pseudogenes miRNA recognition elements...
SpringerPlus 2015, 4(Suppl 1):L1 MicroRNAs (miRNAs) are short, 22-25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3'-untranslated region (3'-UTR) of coding mRNA targets, interrupting translation and inducing degradation these targets.The 3'-UTRs brain compared to other tissues predict important roles for miRNAs.Supporting this notion, we found miRNAs co-evolved their target transcripts, non-coding pseudogenes miRNA recognition elements...