A5031403529- Osteoarthritis Treatment and Mechanisms
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Mesenchymal stem cell research
- Blood properties and coagulation
- Periodontal Regeneration and Treatments
- Diversity and Career in Medicine
- 3D Printing in Biomedical Research
- Career Development and Diversity
- Electrospun Nanofibers in Biomedical Applications
- Knee injuries and reconstruction techniques
- Biomedical and Engineering Education
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Bone and Joint Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Collagen: Extraction and Characterization
- Silk-based biomaterials and applications
- Higher Education Research Studies
- Blood groups and transfusion
- Cellular Mechanics and Interactions
- Microfluidic and Bio-sensing Technologies
- Racial and Ethnic Identity Research
- Iron Metabolism and Disorders
- Leadership, Courage, and Heroism Studies
Franklin W. Olin College of Engineering
2020-2025
American Association For The Advancement of Science
2023
Georgia Institute of Technology
2008-2020
City University of New York
2017-2020
City College
2018-2020
City College of New York
2013-2020
Rice University
2016
The Wallace H. Coulter Department of Biomedical Engineering
2008-2015
Emory University
2011-2014
Northeastern University
1995-2007
Adult mesenchymal stem cells (MSCs) hold great promise for regenerative medicine because of their self-renewal, multipotency, and trophic immunosuppressive effects. Due to the rareness high heterogeneity freshly isolated MSCs, extensive in-vitro passage is required expand populations prior clinical use; however, senescence usually accompanies can potentially affect MSC characteristics functionality. Therefore, a thorough characterization variations in phenotype differentiation potential...
The history of the scientific enterprise demonstrates that it has supported gender, identity, and racial inequity. Further, its institutions have allowed discrimination, harassment, personal harm racialized persons women. This resulted in a suboptimal demographically narrow research innovation system, concomitant limited lens on agendas, less effective knowledge translation between science society. We argue that, to reverse this situation, community must reexamine values then collectively...
Abstract This paper discusses conceptions of identity in relation to science education and presents material from a series interviews focus groups with graduate students technology. Given difficulties retention levels significant participation by minority indicated aggregate data, the issue race, as it informs critical interactions at majority research university, is explored terms its effects on formation. It argued that we need look “real‐time” see how subtle affect students. These reveal...
Abstract Mesenchymal stem cells (MSCs) express an osteoblastic phenotype when treated with BMP‐2, and BMP‐2 is used clinically to induce bone formation although high doses are required. Pulsed electromagnetic fields (PEMF) also promote osteogenesis in vivo, part through direct action on osteoblasts. We tested the hypothesis that PEMF enhances of MSCs presence inductive stimulus like BMP‐2. Confluent cultures human were grown calcium phosphate disks osteogenic media (OM), OM containing 40...
Abstract Polydimethylsiloxane (PDMS) silicone elastomer is extensively used in soft lithography processes to fabricate microscale or nano scale systems for microfluidic cell culture applications. Though PDMS biocompatible, it not an ideal material due its poor adhesion properties. In this study, surfaces were modified promote intestinal adhesion, the interest of testing feasibility using microfabricated high throughput drug screening. Modification techniques included changing chemical...
(1) Background: This paper aims to present and discuss the most significant challenges encountered by STEM professionals associated with remote working during COVID-19 lockdowns. (2) Methods: We performed a qualitative analysis of 921 responses from 76 countries open-ended question: "What has been challenging lockdown for you, and/or your family?" (3) Findings: Participants reported within immediate family include responsibilities school, childcare, children's wellbeing; loss social...
Hydrodynamic forces in bioreactors can decisively influence extracellular matrix deposition engineered cartilage constructs. In the present study, reduced fluid shear, high-axial mixing environment provided by a wavy-walled bioreactor was exploited cultivation of constructs using polyglycolic acid scaffolds seeded with bovine articular chondrocytes. Increased growth as defined weight, cell proliferation and observed from comparison those spinner flasks cultured under same conditions. The wet...
Abstract Controlled differentiation of mesenchymal stem cells (MSCs) into the chondrogenic lineage is crucial for in vitro generation neocartilage, yet achieving it remains challenging. Traditional protocols MSC using exogenous inductive molecules, such as transforming growth factor-β, fall short meeting needs clinical applications because they yield differentiated that exhibit hypertrophic characteristics and subsequently facilitate endochondral bone formation. The objective current study...
The COVID-19 pandemic has forced many people, including those in the fields of science and engineering, to work from home. new working environment caused by is assumed have a different impact on amount that women men can do Particularly, if major burden child other types care still predominantly shoulders women. As such, survey was conducted assess main issues biomedical engineers, medical physicists (academics professionals), similar professionals been facing when home during pandemic. A...
Interview with Valerie Montgomery Rice on opportunities for achieving a diverse student body and workforce after the Supreme Court’s decision affirmative action. (11:32)Download The decisions in two cases eliminate consideration of race university admissions. Regardless rulings, medical education can sustain efforts supporting diversity.
Abstract A resorbable bone cement was formulated from N ‐vinyl‐2‐pyrrolidinone (VP), the unsaturated polyester poly(propylene fumarate) (PPF), and inorganic filler tribasic calcium phosphate (hydroxy apatite). Cure, initiated by benzoyl peroxide accelerated N,N ‐dimethyl‐ p ‐toluidine, resulted in formation of VP crosslinks between chains. During cure hardened a viscous moldable putty to rigid structure with shore D hardness 50–60. The purpose this study determine fractions PPF incorporated...
Abstract Physical forces experienced by engineered‐tissues during in vitro cultivation influence tissue growth and function. The hydrodynamic environment within bioreactors plays a decisive role providing the necessary physical stimuli nutrient transport to support development. Our overall goal is investigate interrelationships between local bioreactor structural functional properties order optimize production of clinically relevant engineered‐tissues. To this end, we used computational...
Abstract A novel wavy‐walled bioreactor designed to enhance mixing at controlled shear stress levels was used culture chondrocytes in suspension. Chondrocyte aggregation suspensions mixed 30, 50, and 80 rpm characterized the compared with that conventional smooth‐walled baffled‐walled spinner flask bioreactors. Aggregation terms of percentage cells aggregated over time, aggregate size changes time. The kinetics chondrocyte observed bioreactors composed two phases: early between 0 2 h...
Abstract The wavy‐walled bioreactor (WWB) possesses a novel geometry comprised of walls with sinusoidal waves that mimic baffles in an effort to promote mixing. This provides unique hydrodynamic environment suitable for the cultivation mammalian cells and tissues investigation fluid mechanical effects on cell tissue growth development. In present study, mixing WWB was characterized compared conventional spinner flask (SF). key parameters included this characterization were time, residence...
Recent in vivo studies suggest that adherent leukocytes bind RBCs and contribute to the microvascular pathology characterizes sickle cell disease (SCD). A parallel-plate flow assay was used: investigate capture of by neutrophils, monocytes, T-lymphocytes; examine whether RBC is elevated patients with SCD; determine hydroxyurea (HU) therapy affects these interactions. Four measures cell-cell adhesion were TNF-alpha-treated human umbilical vein endothelial cells (HUVECs), percent captured...