A5079351805- Indoor Air Quality and Microbial Exposure
- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Graphene and Nanomaterials Applications
- Fullerene Chemistry and Applications
- Heavy metals in environment
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Radioactive contamination and transfer
- Odor and Emission Control Technologies
- Carbon Nanotubes in Composites
- Radioactive element chemistry and processing
- Infection Control and Ventilation
- Air Quality Monitoring and Forecasting
- Inhalation and Respiratory Drug Delivery
- Urban Green Space and Health
- Noise Effects and Management
- Advanced Chemical Sensor Technologies
- Nuclear and radioactivity studies
- Recycling and Waste Management Techniques
- Radioactivity and Radon Measurements
- Antenna Design and Optimization
- Inorganic and Organometallic Chemistry
- Toxic Organic Pollutants Impact
- Energy Harvesting in Wireless Networks
National Institute of Advanced Industrial Science and Technology
2016-2025
Ehime University
2025
Tohoku University
2023
Akita Prefectural University
2016-2021
The University of Kitakyushu
2016-2021
Maebashi Institute of Technology
2016-2021
University of Niigata Prefecture
2016-2021
Tokyo Institute of Technology
2021
National Institute for Japanese Language and Linguistics
2020
Institute of Archaeology
2020
To elucidate the effect of size on pulmonary toxicity single-wall carbon nanotubes (SWCNTs), we prepared two types dispersed SWCNTs, namely relatively thin bundles with short linear shapes (CNT-1) and thick long (CNT-2), conducted rat intratracheal instillation tests in vitro cell-based assays using NR8383 alveolar macrophages. Total protein levels, MIP-1α expression, cell counts BALF, histopathological examinations revealed that CNT-1 caused inflammation slower recovery CNT-2 elicited acute...
To identify potential countermeasures for coronavirus disease (COVID-19), we determined the air exchange rates in stationary and moving train cars under various conditions July, August, December 2020 Japan. When doors were closed, both trains increased with increasing area of window-opening (0.23-0.78/h at 0 m
We used fullerenes, whose dispersion at the nano-level was stabilized by grinding in nitrogen gas an agitation mill, to conduct intratracheal instillation study and inhalation exposure study. Fullerenes were individually dispersed distilled water including 0.1% Tween 80, diameter of fullerenes 33 nm. These suspensions directly injected as a solution The reference material nickel oxide water. Wistar male rats intratracheally received dose 0.1 mg, 0.2 or 1 mg sacrificed after 3 days, week,...
The organ-tissue distribution and clearance of Degussa P25 TiO2 nanoparticles were determined after intravenous administration to rats (0.95 mg/kg bodyweight) using an inductively coupled plasma sector field mass spectrometer. detection limits Ti analysis, 0.54 1.4 ng/mL for blood urine 0.35-2.0 ng/g tissue several organ tissues, enabled determination organs in which content could not be previously due low concentrations. Blood concentrations 420 19 at 5 15 min administration, equivalent...
Phthalates are widely used as plasticizer and associated with various health issues. Recently, non-phthalate plasticizers replacing phthalates; however, the exposure to these substances risk in Japan is unclear. In this study, we assessed concentrations of phthalates, plasticizers, phthalate degradation products house dust determined their respective risks via oral dermal routes. Twelve seven two were obtained from 100 Japanese homes. The median concentration di(2-ethylhexyl) (DEHP),...
Comprehensive monitoring studies on the multiple exposure status to persistent organic pollutants (POPs), halogenated natural products (HNPs), and organophosphate esters (OPEs) of coastal biota are quite limited worldwide, especially for wild sessile bivalves. The present study performed multi-target analyses POPs, HNPs, OPEs in mussel oyster samples collected 2017 2019 from areas Seto Inland Sea, largest semi-enclosed sea Japan. For OPEs, we established a highly accurate analytical method...
Relationships between the physical properties of carbon nanotubes (CNTs) and their toxicities have been studied. However, little research has conducted to investigate pulmonary pleural inflammation caused by short-fiber single-walled CNTs (SWCNTs) multi-walled (MWCNTs). This study was performed characterize differences in rat intratracheal instillation with doses 0.15 or 1.5 mg/kg either short-sized SWCNTs MWCNTs. Data from bronchoalveolar lavage fluid analysis, histopathological findings,...
The toxicokinetics of nanomaterials are an important factor in toxicity, which may be affected by slow clearance and/or distribution the body. Four types nickel oxide (NiO) nanoparticles were single-administered intratracheally to male F344 rats at three doses 0.67–6.0 mg/kg body weight. sacrificed under anesthesia and lung, thoracic lymph nodes, bronchoalveolar lavage fluid, liver, other organs sampled for Ni burden measurement 3, 28, 91 days post-administration; excretion was measured 6 24...
Culture-independent DNA sequencing of fungal internal transcribed spacer 2 (ITS2) region was compared to a culture-dependent morphological identification technique characterize house dust-borne communities. The abundant genera were Aspergillus, Wallemia, Cladosporium, and Penicillium. Statistically significant between-method correlations observed for Wallemia Cladosporium (Spearman's ρ = 0.75 0.72, respectively; p < 0.001). Penicillium tended be detected with much higher (averaged 26-times)...
This study aimed to clarify whether fullerene C60 nanoparticles induced lipid peroxidation in Cyprinus carpio brains. A stable well-characterized aqueous suspension of nanoparticle (diameter: 50th and 95th percentiles, 36 95 nm respectively) with 0.1% Tween80 solution was prepared by bead milling. Lipid hydroperoxides (LPO) were measured vitro homogenized fish brain tissues containing 33 μg/mg-protein dispersed under light dark conditions verify the ability interference exposure using a...
Because of the expansion functionalities available for modification fullerene C60 and its derivatives, their uses are increasing. However, consequences exposure to human health have not been fully studied. In vitro experiments useful risk assessment understanding potential applications. insolubility pristine in water makes evaluation cellular responses difficult. To overcome this problem, we prepared a stable uniform C60-medium dispersion examinations. addition, examined effect on...
Fullerene (carbon sixty [C60]) has potential industrial and medical applications. In the future, people working in or residing near manufacturing facilities may be exposed to C60. Therefore, quantitative data on long-term C60 clearance from lungs are required. To estimate rate deposition fraction of inhalation exposure, burden lungs, liver, brain rats was determined after intratracheal instillation inhalation. Male Wistar were intratracheally instilled with different concentrations a...
As COVID-19 continues to spread, infection risk on public transport is concerning. Air exchange rates (ACH) and advection-diffusion of CO2 particles were determined in a route bus evaluate the risk. ACH increased with speed whether windows open or closed, greater when more open. With two windows, was front rear window than both ventilation fans set exhaust, double that supply. air conditioning (AC) off, spread proportionally at same rate from source, whereas AC on, about half , because might...
Objective: This study was conducted to confirm the definition of multiple chemical sensitivity (MCS) in actual life: that symptoms are provoked organs by exposure to, and ameliorated avoidance of, chemicals at low levels. We used Ecological Momentary Assessment monitor everyday active sampling passive methods measure environmental exposure. Methods: Eighteen patients with MCS, diagnosed according 1999 consensus criteria, 12 healthy controls participated this study. Fourteen underwent 1-week...