A5101726508- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- ECG Monitoring and Analysis
- Complex Systems and Time Series Analysis
- Neural dynamics and brain function
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Statistical Methods in Clinical Trials
- Dementia and Cognitive Impairment Research
- Moyamoya disease diagnosis and treatment
- Theoretical and Computational Physics
- Coenzyme Q10 studies and effects
- Complex Network Analysis Techniques
- Advanced Proteomics Techniques and Applications
- Computational Drug Discovery Methods
- Ginseng Biological Effects and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Radioactivity and Radon Measurements
- Phonocardiography and Auscultation Techniques
- Spondyloarthritis Studies and Treatments
- Pharmacological Effects of Natural Compounds
- Opinion Dynamics and Social Influence
- Nuclear Receptors and Signaling
- Diverse Approaches in Healthcare and Education Studies
Hanyang University
2024
Biostatistical Consulting (United States)
2024
Tampere University
2016-2022
Mukogawa Women's University
2021-2022
Korea Institute of Radiological and Medical Sciences
2020
Ewha Womans University
2012-2013
Ewha Womans University Medical Center
2011
In this study, we demonstrate that activation of AMP-activated protein kinase (AMPK) with glabridin alleviates adiposity and hyperlipidemia in obesity. several obese rodent models, decreased body weight a concomitant reduction fat cell size. Further, ameliorated fatty liver plasma levels triglyceride cholesterol. accordance these findings, suppressed the expression lipogenic genes such as sterol regulatory element binding transcription factor (SREBP)-1c, acid synthase (FAS), acetyl-CoA...
Background Recent findings suggest that NADH-dependent enzymes of the plasma membrane redox system (PMRS) play roles in maintenance cell bioenergetics and oxidative state. Neurons tumor cells exhibit differential vulnerability to metabolic stress, with important implications for development therapeutic interventions promote either survival (neurons) or death (cancer cells). Methods Findings Here we used human neuroblastoma low high levels PMRS enzyme NADH-quinone oxidoreductase 1 (NQO1)...
Healthy human heart rate fluctuates overtime showing long-range fractal correlations. In contrast, various cardiac diseases and normal aging show the breakdown of complexity. Recently, it was shown that induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) intrinsically exhibit behavior as in humans. Here, we investigated complexity hiPSC-derived long QT-cardiomyocytes (LQT-CMs). We recorded extracellular field potentials from hiPSC-CMs at baseline under effect compounds including...
We study complex scaling properties of RR and QT intervals electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat (IBI) field potential durations (FPD) spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis Poincaré plots reveal remarkable similarities between ECG hiPSC-CM data. In particular, no statistically significant difference was found in short- long-term exponents...
Abstract The relation between the electrical properties of heart and beating rate is essential for functioning. This central when calculating “corrected QT interval” — an important measure risk potentially lethal arrhythmias. We use transfer entropy method from information theory to quantitatively study mutual dynamics ventricular action potential duration (the interval) length beat-to-beat (RR) interval. show that healthy individuals there a strong asymmetry in transfer: flow RR dominates...
Abstract This study identified occupational factors associated with radiation exposure in Korea. Survey data of 16 037 workers from 2016 to 2017, including lifestyle and characteristics, were combined the National Dose Registry. Higher average annual doses observed groups exhibiting health risk such as body mass index (BMI) smoking. Average also differed according daily working hours, use protection gear, calendar year hiring employment status. Moreover, influence different on dose...
Abstract The deposition of beta-amyloid (Aβ) in the brain precedes onset symptoms such as cognitive impairment Alzheimer’s disease (AD); therefore, early detection Aβ accumulation is crucial. We previously reported applicability QPLEX TM Alz plus assay kit for prescreening accumulation. Here, we tested specific application a large cohort cognitively normal (CN) individuals varying ages included total 221 CN participants with or without Aβ. biomarkers were characterized based on age groups (1...
Alzheimer's disease (AD) is the leading cause of dementia, and many studies have focused on finding effective blood biomarkers for accurate diagnosis this disease. Predicting cerebral amyloid deposition considered key AD because a hallmark pathogenesis. Previously, were discovered to predict deposition, further efforts been made increase their sensitivity specificity. In study, we analyzed blood-test factors (BTFs) that can be commonly measured in medical health check-ups from 149...
We study RR interval (RRI) correlations in subjects with long QT syndrome (LQTS).We aim to find distinctive differences nonlinear heart rate variability (HRV) measures between the LQTS and healthy controls.We analyze 24-hour Holter recordings from 127 controls 115 samples unified age distributions.Beta blockers (BB), which are known affect HRV, a common treatment for LQTS, that is primary confounding factor be accounted for.We compute conventional short-scale (4-16 RRIs) detrended...
To investigate the factors associated with cause-specific discontinuation of long-term anti-tumor necrosis factor (TNF) agent use in patients ankylosing spondylitis (AS).
A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in rate variability (HRV).It is recently shown that fractal dynamics also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).In this study, we investigate short-and correlations beat (BRV) hiPSC-CMs, obtained from a subject and symptomatic asymptomatic long QT syndrome patients.It it important to distinguish correlation properties short time scales, as the scaling exponents...
Transgene technology is valuable and helpful in many fields, including basic medical biological research, biotechnology, therapy. Recent advances targeting accelerate the production of transgenic plants animals application for gene To develop technology, we examine utility as new safe harbor locus, l-gulono-γ-lactone oxidase (Gulo) locus human mice. We performed experiments vitro vivo knockout knockin mouse cell lines to validate their applicability using these loci. The Gulo might be good...
ABSTRACT The relation between the electrical properties of heart and beating rate is essential for functioning. This central when calculating “corrected QT interval” — an important measure risk potentially lethal arrhythmias. We use transfer entropy method from information theory to quantitatively study mutual dynamics ventricular action potential duration (the interval) length beat-to-beat (RR) interval. show that healthy individuals there a strong asymmetry in transfer: flow RR dominates...
Abstract Background: Alzheimer's disease (AD) is an irreversible neurodegenerative characterized by the hallmark finding of cerebral amyloid deposition. Many researchers have tried to predict existence deposition using easily accessible blood plasma samples, but effectiveness such strategies remains controversial. Methods: We developed a new multiplex kit, QPLEX TM Alz plus assay which uses proteomics-based biomarkers prescreen for A total 300 participants who underwent Pittsburgh compound B...
Abstract BackgroundThe deposition of beta-amyloid (Ab) in the brain precedes onset symptoms such as cognitive abnormality Alzheimer’s disease (AD); therefore, it is best to detect Ab accumulation early possible.MethodsWe previously reported that QPLEX TM Alz plus assay could be used for pre-screening brain. In this study, we applied kit cognitively normal (CN) group positivity. Total 221 CN participants with or without were included. ResultsReceiver operating characteristics (ROC) curve...
본 연구의 목적은 2020년 COVID-19로 인해 대학교육의 전면에 등장한 원격수업에 대한 학습자의 만족도 변화를 분석함으로써 향후 대학 원격수업 운영의 방향성을 재고하기 위해서이다. 연구방법은 D대학교에서 2020학년도 1학기와 2학기에 실시한 조사와 수강 의향에 설문 조사결과를 분석하는 것이다. 조사 연구결과에 따르면 D대학교의 경우 학기가 진행될수록 만족도가 상승하고 있으며 수강의향도 높아지고 있음이 드러났다. 하지만 소통의 제약이나 학습패턴 부적응 등은 확대를 위해 개선되어야 할 부분으로 확인되었다. 이러한 결과를 바탕으로 연구에서는 고려하여 대학교육이 재편되어야 필요성을 제기하고 자기주도적 학습역량을 강화할 수 있는 원격수업의 운영 방안을 제안하였다.
Long-range correlation in financial time series reflects the complex dynamics of stock markets driven by algorithms and human decisions. Our analysis exploits ultrahigh frequency order book data from NASDAQ Nordic over a period three years to numerically estimate power-law scaling exponents using detrended fluctuation (DFA). We address inter-event durations (order order, trade trade, cancel cancel) as well cross-event (time submission its or cancel). find strong evidence long-range...
We characterize the complexity of interbeat intervals (IBIs) and field potential durations (FPDs) humaninduced plurioptent stem cell-derived cardiomyocytes (hiPSC-CMs).The is assessed using multiscale entropy (MSE) method up to scale ten beats.The MSE profiles healthy diseased (long-QT syndrome) hiPSC-CMs show important differences, which demonstrate usefulness in characterization cells analysis hereditary cardiac diseases.We that intrinsic possibly altered by differentiation methods, as...