A5044954943- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Periodontal Regeneration and Treatments
- Connective Tissue Growth Factor Research
- Knee injuries and reconstruction techniques
- Spine and Intervertebral Disc Pathology
- Cell Adhesion Molecules Research
- Additive Manufacturing and 3D Printing Technologies
- Bone health and treatments
- Mesenchymal stem cell research
- Polymer Surface Interaction Studies
- Proteoglycans and glycosaminoglycans research
- Shoulder Injury and Treatment
- 3D Printing in Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
- Biomarkers in Disease Mechanisms
- Cellular Mechanics and Interactions
- Bee Products Chemical Analysis
- Total Knee Arthroplasty Outcomes
- Musculoskeletal pain and rehabilitation
Freie Universität Berlin
2023
Humboldt-Universität zu Berlin
2023
Charité - Universitätsmedizin Berlin
2011-2023
TransTissue (Germany)
2011-2019
Universitätsklinikum Würzburg
2014
University of Würzburg
2014
To create artificial cartilage in vitro, mimicking the function of native extracellular matrix (ECM) and morphological cartilage-like shape is essential. The interplay cell patterning concentration has high impact on phenotype viability printed cells. advance capabilities bioprinting, we investigated different ECMs to an vitro chondrocyte niche. Therefore, used methacrylated gelatin (GelMA) hyaluronic acid (HAMA) a stereolithographic bioprinting approach. Both materials have been shown...
Abstract In cartilage repair, platelet‐rich plasma (PRP) is used in one‐step approaches utilizing microfracture and matrix‐induced chondrogenesis procedures, bone marrow‐derived cell transplantation, or intra‐articular injection. The aim of our study was to evaluate the effect human PRP on migration chondrogenic differentiation subchondral progenitors. Human progenitors were derived from cortico‐spongious (CSP), analyzed for their capacity upon treatment 96‐well chemotaxis assays cultured...
Objective The objective was to evaluate the proliferating, migratory and extracellular matrix (ECM) forming potential of annulus fibrosus cells derived from early (edAFC) or advanced (adAFC) degenerative tissue their usability as a possible cell source for regenerative approaches AF closure. Design EdAFC ( n = 5 Pfirrman score 2-3) adAFC (n 4-5) were isolated patients undergoing spine stabilizing surgery. Cell migration on stimulation with human serum (HS), platelet-rich plasma (PRP),...
Abstract Since loss of meniscus is correlated with an increasing risk for osteoarthritis, meniscal scaffolds are proposed as new strategies. Development a suitable scaffold has to take into account differing thickness, exposure compressive and tensile forces combined high porosity biocompatibility the material. After physical testing three flat composed different modified polyglycolic acid (PGA) fibers, three‐dimensional meniscus‐shaped PGA‐hyaluronan implant was generated. Micro‐computed...
Intervertebral disc degeneration is a major source of back pain. For intervertebral regeneration after herniation fast closure anulus fibrosus (AF) defects crucial. Here, the use C-C motif chemokine ligand 25 (CCL)25 in comparison to differentiation factors such as transforming growth factor (TGF)β3, bone morphogenetic protein (BMP)2, BMP7, BMP12, and BMP14 (all concentrations 10, 50 100 ng/mL) was tested an vitro micro mass pellet model with isolated cultivated human AF-cells (n = 3) induce...
Background: For regenerative therapies in the orthopedic field, one prerequisite for therapeutic success treatment of cartilage defects is potential body's own cells to migrate, proliferate and differentiate into functional cells. While this has been demonstrated mesenchymal stem progenitor (MPC) from healthy tissue sources, degenerative conditions unclear. In study MPC derived subchondral cancellous bone with diagnosed osteoarthritis evaluated vitro. Methods: OaMPC isolated chips three...
Plasma fibronectin (pFN) plays a crucial role in wound healing by binding to integrins and inducing cell migration. It is known induce the migration proliferation of mesenchymal progenitor cells vitro, which play key during microfracture cartilage repair. Endogenous chondrocytes from native defect rim might aid In this study, effect pFN on proliferation, migration, differentiation was tested human articular chondrocytes. Results showed that treatment with increased range 1–30 μg/ml as no...