A5053898103- Mesenchymal stem cell research
- Fibroblast Growth Factor Research
- Tissue Engineering and Regenerative Medicine
- Bone Metabolism and Diseases
- Muscle Physiology and Disorders
- Bone health and treatments
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Connective Tissue Growth Factor Research
- Connective tissue disorders research
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Pancreatic function and diabetes
- Dental Implant Techniques and Outcomes
- Biomarkers in Disease Mechanisms
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- Pluripotent Stem Cells Research
- Growth Hormone and Insulin-like Growth Factors
- Phagocytosis and Immune Regulation
- Endodontics and Root Canal Treatments
- Orthopaedic implants and arthroplasty
- Redox biology and oxidative stress
- Proteoglycans and glycosaminoglycans research
University of Würzburg
2006-2024
Bavarian Polymer Institute
2019-2021
Universitätsklinikum Würzburg
2007-2014
University of York
2010
Primary osteoporosis is an age-related disease characterized by imbalance in bone homeostasis. While the resorptive aspect of has been studied intensely, less known about anabolic part syndrome or presumptive deficiencies regeneration. Multipotent mesenchymal stem cells (MSC) are primary source osteogenic In present study we aimed to unravel whether MSC biology directly involved pathophysiology and therefore performed microarray analyses hMSC elderly patients (79-94 years old) suffering from...
Abstract Macrophages are key players of the innate immune system that can roughly be divided into pro-inflammatory M1 type and anti-inflammatory, pro-healing M2 type. While a transient initial state is helpful, prolonged inflammation deteriorates proper healing subsequent regeneration. One promising strategy to drive macrophage polarization by biomaterials precise control over biomaterial geometry. For regenerative approaches, it particular interest identify geometrical parameters direct...
Abstract The molecular events associated with the age‐related gain of fatty tissue in human bone marrow are still largely unknown. Besides enhanced adipogenic differentiation mesenchymal stem cells (MSCs), transdifferentiation osteoblast progenitors may contribute to bone‐related diseases like osteopenia. Transdifferentiation MSC‐derived into adipocytes and vice versa has previously been proven feasible our cell culture system. Here, we focus on mRNA species that regulated during represent...
Controlling the adipo-osteogenic lineage decision of trabecular human bone marrow stromal cells (hBMSCs) in favor osteogenesis represents a promising approach for osteoporosis therapy and prevention. Previously, Fibroblast Growth Factor 1 (FGF1) its subfamily member FGF2 were scored as leading candidates to exercise control over skeletal precursor commitment albeit literature results are highly inconsistent. We show here that FGF1 2 strongly prevent osteogenic differentiation hBMSCs....
Abstract In vitro co-cultures of different primary human cell types are pivotal for the testing and evaluation biomaterials under conditions that closer to in vivo situation. Especially macrophages mesenchymal stem cells (MSCs) interest, as they both present involved tissue regeneration inflammatory reactions play crucial roles immediate onset regenerative processes, thus reflecting decisive early phase biomaterial contact with host. A co-culture system these might allow assessment...
Pancreatic islet beta-cell replenishment can be driven by epithelial cells from exocrine pancreas via epithelial-mesenchymal transition (EMT) and the reverse process MET, while specified pancreatic mesenchymal control cell development maintenance. The role of human islet-derived precursor (hIPCs) in regeneration support endocrine islets is under investigation. Here, we analyzed hIPCs as to their immunophenotype, multilineage differentiation capacity, gene profiling, comparison bone...
Melt electrowriting (MEW) is an additive manufacturing technology that produces readily handleable fibrous scaffolds with controlled geometry to support cell infiltration. Although MEW have excellent potential for delivery in regenerative medicine applications, studies date primarily focused on polymers such as poly(ε-caprolactone) (PCL) lack bioactive cues affect function. To address this aspect, extracellular matrix (ECM) coatings were developed a proadipogenic platform human mesenchymal...
ObjectiveThe identification of signaling pathways involved in megakaryocytopoiesis is essential for development novel therapeutics to treat hematological disorders. Following our previous findings that megakaryocytes express functional channel-forming N-methyl-D-aspartate-type glutamate receptors, here we aimed determine the release capacity undifferentiated and differentiated role soluble N-ethyl maleimide-sensitive factor attachment protein receptor (SNARE) proteins are known be associated...
Mesenchymal stem cells (MSC) are derived from mesodermal precursor and committed towards mesenchymal differentiation. They scattered all over the organism, situated in bone, cartilage, adipose tissue accompany organs for regeneration structural functional support. MSC populations not homogenous, their signature is variable according to localization. A process called "epithelial transition" fundamental development of mesoderm. Epithelial-mesenchymal interactions specify this may influence...
ABSTRACT Doping of brushite cements with metal ions can entail many positive effects on biological and physicochemical properties. Cu 2+ are known to exhibit antibacterial properties additionally have different cells as trace elements, whereas high concentrations cytotoxic. For therapeutical applications bone cement, a combination good biocompatibility sufficient mechanical is required. Therefore, the aim this study was investigate aspects, relevant for application, cement ‐doped...
Bone development, regeneration and maintenance are governed by osteogenic differentiation processes from mesenchymal stem cells through to mature bone cells, which directed local growth factors modulated strongly hormones. Mesenchymal develop both mesoderm neural crest can give rise of tissues, such as bone, cartilage, muscle, tendons discs. There only limited data regarding the effects hormones on early events, regulation stemness cell pool. Hormones, estrogens, vitamin D-hormone...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)