A5009731881- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Carbohydrate Chemistry and Synthesis
- Advanced Drug Delivery Systems
- Protease and Inhibitor Mechanisms
- Caveolin-1 and cellular processes
- Protein Kinase Regulation and GTPase Signaling
- Barrier Structure and Function Studies
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Lipid Membrane Structure and Behavior
- Oral microbiology and periodontitis research
- S100 Proteins and Annexins
- Proteoglycans and glycosaminoglycans research
- Advancements in Transdermal Drug Delivery
- Signaling Pathways in Disease
- Nitric Oxide and Endothelin Effects
- ATP Synthase and ATPases Research
- RNA Research and Splicing
- Biochemical and Structural Characterization
- PI3K/AKT/mTOR signaling in cancer
- Dermatology and Skin Diseases
Freie Universität Berlin
2000-2024
Charité - Universitätsmedizin Berlin
2013-2024
Humboldt-Universität zu Berlin
2018-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2017-2021
Evotec (Germany)
2021
Medizinische Hochschule Hannover
2014
University of Regensburg
2014
Bayer (Germany)
2014
PharmacoGenetics (China)
2011
Abstract Axonal degeneration is an early and ongoing event that causes disability disease progression in many neurodegenerative disorders of the peripheral central nervous systems. Chemotherapy-induced neuropathy (CIPN) a major cause morbidity main dose reductions discontinuations cancer treatment. Preclinical evidence indicates activation Wallerian-like pathway driven by sterile alpha TIR motif containing 1 (SARM1) responsible for axonopathy CIPN. SARM1 driver evolutionarily conserved...
Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role Th17 cells in ileitis is unknown. We report interleukin (IL)-23–mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation ileum infected mice. MMP-2 deficiency as well therapeutic or prophylactic selective blockage protected mice from T. gondii–induced immunopathology. Moreover, IL-23–dependent IL-22 was essential for ileitis, whereas IL-17...
N-Acetylneuraminic acid is a main constituent of glycoproteins and gangliosides. In many membrane-bound receptors it the target for external stimuli. The key enzyme its biosynthesis bifunctional UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, catalysing first two steps in cytosol. rat was previously isolated characterised. this report we present corresponding human cDNA sequence, compare with primary structure rodent enzyme, analysis expression different tissues cell lines.
Resistance arteries are the site of earliest manifestations many cardiovascular and metabolic diseases. Flow (shear stress) is main physiological stimulus for endothelium through activation vasodilatory pathways generating flow-mediated dilation (FMD). The role FMD in local blood flow control angiogenesis well established, alterations early markers disorders. alpha(1)-Integrin, which has a angiogenesis, could be involved FMD. was studied mesenteric resistance (MRA) isolated arteriographs....
Neuraminic acids are widely expressed as terminal carbohydrates on glycoconjugates and involved in a variety of biological functions. The key enzyme N-acetylneuraminic acid synthesis is UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase, which catalyses the first two steps neuraminic biosynthesis cytosol. In this study we report complete amino sequence mouse kinase. ORF 2166 bp encodes 722 protein with predicted molecular mass 79.2 kDa. Northern blot analysis situ hybridization...
Abstract Background One key approach for anticancer therapy is drug combination. Drug combinations can help reduce doses and thereby decrease side effects. Furthermore, the likelihood of resistance reduced. Distinct alterations in tumor metabolism have been described past decades, but has yet to be targeted clinical cancer therapy. Recently, we found evidence synergism between dichloroacetate (DCA), a pyruvate dehydrogenase kinase inhibitor, HIF-1α inhibitor PX-478. In this study, aimed...
Integrin adhesion receptors have been implicated in bidirectional signal transduction. The dynamic regulation of integrin affinity and avidity as well post-ligand effects involved outside-in signaling depends on the interaction integrins with cytoskeletal proteins. In this study, we attempted to identify cytoplasmic binding partners α<sub>1</sub>β<sub>1</sub> integrin. We were able show that cell α<sub>1</sub>β<sub>1</sub>-specific substrates results association phospholipase Cγ (PLCγ)...
The aim of this study was to: (1) investigate the expression patterns antimicrobial peptides (AMPs), specifically psoriasin (S100A7) and calgranulin A B (S100A8/A9), in patients with oral lichen planus (OLP) compared to healthy individuals; (2) evaluate health-related quality life (OHrQoL) OLP versus controls; (3) impact clinical severity on OHrQoL; (4) assess influence AMP OHrQoL patients.
UDP‐ N ‐acetylglucosamine‐2‐epimerase/ ‐acetylmannosamine kinase (UDP‐GlcNAc 2‐epimerase) is the key enzyme in de novo synthesis pathway of neuraminic acid, which widely expressed as a terminal carbohydrate residue on glycoconjugates. UDP‐GlcNAc 2‐epimerase bifunctional and catalyzes first two steps acid cytosol, conversion ‐acetylglucosamine to ManAc phosphorylation ManAc‐6‐phosphate. So far, regulation this essential by posttranslational modification has not been shown. Since cytosolic...
Abstract The search for specific anticancer drugs that do not interfere with DNA synthesis or influence the cytoskeleton has led to development of modified phospholipids antiproliferative properties. These compounds cause remodeling structure and function plasma membranes. Recently, we described novel compounds, glycosidated phospholipids, surprisingly inhibit cell proliferation. contain α‐ D ‐glucose in sn ‐2 position glycerol backbone phosphatidylcholine (PC) platelet‐activating factor...
In the oral cavity, mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, lichen planus) that require therapy. The application topical drugs is one common therapeutic approach. However, their efficacy limited. Dilution effects due to saliva hinder adherence penetration drug formulations. Therefore, bioavailability insufficient, patients suffer from disease over years, if not...
Oral inflammatory diseases are highly prevalent in the worldwide population. Topical treatment of inflammation is challenging due to dilution effects saliva and crevicular fluid. Thus, there a great medical need develop smart anti-inflammatory drug delivery systems for mucosa treatment. We compared two promising dendritic poly(glycerol-caprolactone) sulfate (dPGS-PCL) polymers their applicability oral mucosa. Using an ex vivo porcine tissue model, cell monolayers, full-thickness 3D mucosal...
Abstract Topical treatment of oral inflammatory diseases is challenging due to the intrinsic physicochemical barriers mucosa and continuous flow saliva, which dilute drugs limit their bioavailability. Nanocarrier technology can be an innovative approach circumvent these problems thus improve efficacy topical drug delivery mucosa. Core‐multishell (CMS) nanocarriers are putative systems with high biocompatibility ability adhere penetrate Ester‐based CMS release anti‐inflammatory compound...
Integrins are heterodimeric adhesion receptors consisting of alpha- and beta-subunits capable binding extracellular matrix molecules as well other on neighbouring cells. These interactions induce various signal transduction pathways in many cell types, leading to cytoskeletal reorganization, phosphorylation induction gene expression. Integrin ligation leads cytoplasmic protein-protein requiring both integrin domains, these domains initiation points for focal formation subsequent cascades. In...