A5030041387- Advanced Drug Delivery Systems
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Evolution and Genetic Dynamics
- Polymer Surface Interaction Studies
- Barrier Structure and Function Studies
- Dendrimers and Hyperbranched Polymers
- Mosquito-borne diseases and control
- Malaria Research and Control
- Connexins and lens biology
Charité - Universitätsmedizin Berlin
2022-2024
Freie Universität Berlin
2020-2024
Humboldt-Universität zu Berlin
2020-2024
Max Planck Institute for Infection Biology
2019
Oral inflammatory diseases are highly prevalent in the worldwide population. Topical treatment of inflammation is challenging due to dilution effects saliva and crevicular fluid. Thus, there a great medical need develop smart anti-inflammatory drug delivery systems for mucosa treatment. We compared two promising dendritic poly(glycerol-caprolactone) sulfate (dPGS-PCL) polymers their applicability oral mucosa. Using an ex vivo porcine tissue model, cell monolayers, full-thickness 3D mucosal...
Abstract Topical treatment of oral inflammatory diseases is challenging due to the intrinsic physicochemical barriers mucosa and continuous flow saliva, which dilute drugs limit their bioavailability. Nanocarrier technology can be an innovative approach circumvent these problems thus improve efficacy topical drug delivery mucosa. Core‐multishell (CMS) nanocarriers are putative systems with high biocompatibility ability adhere penetrate Ester‐based CMS release anti‐inflammatory compound...
Periodontitis is one of the most common oral diseases worldwide and caused by a variety interactions between bacteria host. Here, pathogens induce inflammatory host responses that cause secretion proinflammatory cytokines such as IL-1β, IL-6, IL-8 epithelial cells. In various systems, it has been shown inflammation compromises physical barriers, which enables to invade tissue. this study, we investigated barrier properties mucosa under physiological inflamed conditions. For purpose, assessed...
A synthetic route for adhesive core-multishell (CMS) nanocarriers application to the oral mucosa was established using mussel-inspired catechol moieties. The three CMS with 8%, 13%, and 20% functionalization were evaluated loading capacity Nile red, showing an overall of 1 wt%. ability red loaded functionalized bind a moist mucosal surface tested in two complementary adhesion assays under static dynamic conditions monolayers differentiated gingival keratinocytes. Adhesion properties compared...