A5028911763- Urticaria and Related Conditions
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Immune Cell Function and Interaction
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Toxoplasma gondii Research Studies
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Drug-Induced Adverse Reactions
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Complement system in diseases
- Curcumin's Biomedical Applications
- Autoimmune and Inflammatory Disorders Research
- Hemoglobin structure and function
- IL-33, ST2, and ILC Pathways
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- Receptor Mechanisms and Signaling
- Salmonella and Campylobacter epidemiology
- Polyomavirus and related diseases
- Celiac Disease Research and Management
Fraunhofer Institute for Translational Medicine and Pharmacology
2021-2025
Freie Universität Berlin
2019-2025
Charité - Universitätsmedizin Berlin
2010-2025
Humboldt-Universität zu Berlin
2019-2025
Koç University
2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021-2022
German Rheumatism Research Centre
2021
Vall d'Hebron Hospital Universitari
2012
MSB Medical School Berlin
2011
Institute of Medical Microbiology and Hygiene
2009-2010
Background The health beneficial effects of Resveratrol, Curcumin and Simvastatin have been demonstrated in various experimental models inflammation. We investigated the potential anti-inflammatory immunomodulatory mechanisms above mentioned compounds a murine model hyper-acute Th1-type ileitis following peroral infection with Toxoplasma gondii. Methodology/Principal Findings Here we show that after administration or Simvastatin, mice were protected from development survived acute phase...
Background Although Campylobacter jejuni-infections have a high prevalence worldwide and represent significant socioeconomic burden, it is still not well understood how C. jejuni causes intestinal inflammation. Detailed investigation of jejuni-mediated immunopathology hampered by the lack appropriate vertebrate models. In particular, mice display colonization resistance against this pathogen. Methodology/Principal Findings To overcome these limitations we developed novel jejuni-infection...
Abstract Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics assess the effects of human CSU fecal microbial transplantation, Klebsiella pneumoniae , Roseburia hominis metabolites in vivo. microbiota displays low diversity production, high levels, negatively correlates blood levels links to disease activity. Blood lipopolysaccharide are elevated, link rapid relapse,...
Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role Th17 cells in ileitis is unknown. We report interleukin (IL)-23–mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation ileum infected mice. MMP-2 deficiency as well therapeutic or prophylactic selective blockage protected mice from T. gondii–induced immunopathology. Moreover, IL-23–dependent IL-22 was essential for ileitis, whereas IL-17...
Clearance of infection with intracellular pathogens in mice involves interferon-regulated GTPases the IRG protein family. Experiments genetically deficient members this family such as Irgm1(LRG-47), Irgm3(IGTP), and Irgd(IRG-47) has revealed a critical role microbial clearance, especially for Toxoplasma gondii. The vivo another member family, Irga6 (IIGP, IIGP1) been studied less detail. We investigated susceptibility two independently generated mouse strains to T. gondii, Mycobacterium...
A 58-year-old woman with no allergies or rheumatic disease had a 2-year history of spontaneous wheals that occurred daily, accompanied by pruritus, arthralgia, and intermittent fevers; the resolved after several hours without residual hyperpigmentation bruising. C-reactive protein level was elevated, skin biopsy showed dermal neutrophilic infiltration. What is diagnosis what would you do next?
Mast cells (MCs), strategically localized at mucosal surfaces, provide first-line defense against pathogens and shape innate adaptive immune responses. Recent studies have shown that MCs are involved in pathogenic responses to several viruses including herpes simplex viruses, dengue virus, vaccinia virus influenza virus. However, the underlying mechanisms of activation CD8 + T during viral infections not fully understood. Therefore, we investigate role development virus-specific cell using...
Tim-3 has opposing roles in innate and adaptive immunities. It not only dampens CD4+ CD8+ T cells responses but also enhances the ability of macrophages to eliminate intracellular pathogens. After peroral infection with 100 cysts Toxoplasma gondii genetically susceptible C57BL/6 mice develop an unchecked Th1 response associated development small intestinal immunopathology. Here we report that upon T. gondii, both resistant BALB/c exhibit increased frequencies Tim-3+ spleens mesenteric lymph...
Abstract Efficient anti‐viral responses of CD8 + T cells require signals that promote their effector cell differentiation, are mainly provided by dendritic (DCs). Mast (MCs) key drivers DC maturation, but also influence migration and antigen presenting properties therefore indirectly mediate activation. MCs initiate innate immune at pathogen entry sites, the development adaptive after infection, release mediators including chemokines recruit activate during viral infections. However, whether...