A5072275583- Sarcoma Diagnosis and Treatment
- Bone fractures and treatments
- Bone Tumor Diagnosis and Treatments
- Orthopaedic implants and arthroplasty
- Reconstructive Surgery and Microvascular Techniques
- Neuroendocrine regulation and behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Total Knee Arthroplasty Outcomes
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Orthopedic Surgery and Rehabilitation
- Stress Responses and Cortisol
- Tumors and Oncological Cases
- Receptor Mechanisms and Signaling
- Musculoskeletal synovial abnormalities and treatments
- Anesthesia and Pain Management
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Reproductive System and Pregnancy
- Management of metastatic bone disease
- Hip and Femur Fractures
- Oral and Maxillofacial Pathology
- Global Health and Surgery
University of Southern California
2023-2024
City of Hope
2023
City Of Hope National Medical Center
2019-2022
Loma Linda University
2011-2020
Loma Linda University Medical Center
2015-2020
Creative Commons
2020
Adventist University of Haiti
2020
NuVasive (United States)
2018
SUNY Downstate Health Sciences University
2009
Columbia University
2008
Chondrosarcomas (CSs) consist of a heterogenous group primary bone cancers arising from malignant cells which produce cartilaginous matrix. As the second most common cancer, CS are often resistant to systemic chemotherapy due poor vascularization, slow proliferation, and expression multidrug-resistant pumps. Immune checkpoint inhibitors have transformed field oncology now designated as frontline therapy for many solid tumor cancers. Several studies demonstrated increased programed cell death...
Cortical bone drilling for preparation of screw placement is common in multiple surgical fields. The heat generated while may reach thresholds high enough to cause osteonecrosis. This can compromise implant stability. Orthopaedic drill bits are several orders more expensive than their similarly sized, publicly available industrial counterparts. We hypothesize that an bit will generate less during drilling, and the not after cortical passes.We compared 4 4.0 mm orthopaedic 1 3.97 bits. Three...
Objectives: The objectives of this study were (1) to compare the axial and torsional stiffness a dynamic hip screw with two- four-hole side-plate in synthetic model healed stable intertrochanteric femur fracture (2) evaluate load failure, as well propensity peri-implant fracture. Methods: Fourth-generation composite models, simulating osteoporotic bone, implanted 135° screws (DHS) either or without Specimens cyclically loaded up nondestructive determine stiffness. Constructs then failure...
Osteosarcoma is the most common type of bone cancer in adolescents. There have been no significant improvements outcomes since chemotherapy was first introduced. Bupivacaine and lidocaine shown to be toxic certain malignancies. This study evaluates effect these medications on two osteosarcoma cell lines.(1) Does incubation cells with bupivacaine or result death? (2) this from an apoptotic mechanism? (3) Is a specific pathway implicated?Two lines were chosen account for inherent heterogeneity...
Behavioral models of antipsychotic drug (APD) action in the rat are widely used for screening and developing APDs. Valid not only required to be selective specific APDs, but also able dissociate between typical atypical In recent years, newer have been developed that claimed model processes impaired schizophrenic patients. However, these depend on previous administration propsychotic drugs revealing effects raising possibility “model” APD is behavior assessed drug. A valid behavioral should...
Traditionally, intercalary allograft reconstruction after tumor resection has had a high rate of complications, particularly nonunion. Plate and intramedullary nail fixation have been used alone in combination to improve union rates. This study sought evaluate new technique that uses magnetic growing compress the osteotomy sites aid healing answer 2 questions: (1) What is time when using nails? (2) complications occur with this technique? Eight patients 15 minimum follow-up 14 months were...
Arthrodesis of the elbow joint addresses pain due to intra-articular pathology, but with significant functional limitations. Loss motion at is not completely compensated by wrist and shoulder joints fusion thus purely a salvage procedure. Advances in arthroplasty have allowed surgeons address limitations arthrodesis, despite these advances still one replacements higher complication rate. Conversion has been reported for hip, knee, shoulder, ankle. The takedown surgically fused was German...
Traditionally, distraction osteogenesis has been accomplished with an external fixator. All internal transport utilizing magnetic intramedullary nails is a newer technique for bone reconstruction. The Precice Bone Transport Nail new implant that allows noninvasive via magnetically driven motor.This report describes the function of along technical considerations on how to successfully manage defects this technology. Appropriate use nail, preoperative planning, intraoperative considerations,...
Primary sarcomas of the thumb metacarpal are rare malignant lesions. Surgical treatment involves amputation versus tumor resection with reconstruction. If complete is possible, preservation may be considered, as vital to hand function. Following resection, previous reports have described graft reconstruction fusion trapezium or scaphoid. We present two cases sarcoma necessitating that were reconstructed an arthrodesis proximal phalanx second shaft. Arthrodesis allows robust bony contact for...
Osteosarcoma (OS), an aggressive malignancy, is the most common primary bone tumor in children. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to reduce pain and inflammation. NSAIDs have shown be toxic certain malignancies such as colorectal, breast, pancreatic cancers, but not well-studied OS. The purpose of this study assess whether ketorolac induces apoptosis OS cells, compare indomethacin, which has been inhibit proliferation, explore underlying mechanism.A rat cell line...
Recurrence or metastasis remains the major cause of poor prognosis and mortality in Osteosarcoma patients. Therefore, development more effective therapeutic approaches is required. We showed that indomethacin, significantly induces apoptosis MNNG/HOS cell line, which was confirmed by morphological changes, increased Annexin-V + cells nuclear fragmentation. Apoptosis accompanied cleavage caspase-3 PARP, suggesting activation caspase-dependent death. Indomethacin decreased expression...
Distraction osteogenesis is an option for reconstruction of intercalary defects. The use bone transport after tumor surgery has been limited because concerns pin tract infections with external fixation and the theoretical risk causing growth. effects chemotherapy radiation on regenerate healing docking site are also not well studied, but current literature mostly favorable outcomes no evidence proliferation. Precice nail offers a noninvasive method distraction osteogenesis, which eliminates...
Multifocal fibromatosis is a rare entity. We report on two cases where multifocal disease developed after surgical resection. Chronic inflammation and repetitive trauma may be considered risk factor for developing disease.