A5100736980- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Synthesis and biological activity
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Gold and Silver Nanoparticles Synthesis and Applications
- Estrogen and related hormone effects
- Crystal structures of chemical compounds
- Computational Drug Discovery Methods
- Higher Education and Teaching Methods
- Luminescence Properties of Advanced Materials
- Edible Oils Quality and Analysis
- Cancer Immunotherapy and Biomarkers
- Meat and Animal Product Quality
- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- Synthesis and Characterization of Heterocyclic Compounds
- Psoriasis: Treatment and Pathogenesis
- Morinda citrifolia extract uses
- Traditional and Medicinal Uses of Annonaceae
- Inflammatory mediators and NSAID effects
- Phytochemical compounds biological activities
Henan University of Technology
2008-2024
China Pharmaceutical University
2012-2020
State Key Laboratory of Natural Medicine
2014
Nanjing Library
2014
Chinese PLA General Hospital
2011
Dana (United States)
2004
Baidu (China)
2003
Two major challenges of current photodynamic therapy (PDT) are the limited tissue penetration excitation light and poor tumor-selectivity photosensitizer (PS). To address these issues, we developed a multifunctional nanoconstruct consisting upconversion nanoparticles (UCNPs) that transform near-infrared (NIR) to visible zinc(II) phthalocyanine (ZnPc). Folate-modified amphiphilic chitosan (FASOC) was coated on surface UCNPs anchor ZnPc close UCNPs, thereby facilitating resonance energy...
The molecular basis for aging of the kidney is not well understood. MicroRNAs (miRNAs) contribute to processes such as development, differentiation, and apoptosis, but their contribution process unknown. Here, we analyzed miRNA expression profile young (3-month) old (24-month) rat kidneys identified biologic pathways genes regulated by differentially expressed miRNAs. We observed upregulation 18 miRNAs with aging, mainly regulating associated energy metabolism, cell proliferation,...
Photodynamic therapy (PDT) has recently been proposed as an innovative approach to combat multi-drug resistant (MDR) bacteria. To improve the penetration depth of current PDT, a core–shell upconversion nanoparticle (UCNP) based PDT system, composed cationic N-octyl chitosan (OC) coated UCNP loaded with photosensitizer zinc phthalocyanine (OC-UCNP-ZnPc), was constructed enhance antibacterial efficacy against MDR bacteria in deep tissue. The UCNPs displayed higher fluorescence efficiency...
Exploring the synthesis of new biocompatible quantum dots (QDs) helps in overcoming intrinsic toxicity existing QDs composed highly toxic heavy metals (e.g., Cd, Hg, Pb, etc.) and is particularly interesting for future practical application biomedical imaging. Hence, this report, a one-pot approach to oil-soluble (highly metal-free) luminescent quaternary Zn-Ag-In-Se (ZAISe) was designed. Their photoluminescence (PL) emission could be systematically tuned from 660 800 nm by controlling Ag/Zn...
With the rapid development of science and technology, BIM technology has been widely used in civil engineering industry become an important tool to promote progress industry. However, colleges universities still face many challenges teaching mechanics, such as disconnect between theory practice, lack students’ practical innovation ability. Therefore, this paper proposes integrate into reform Engineering Mechanics establish a virtual research room realize sharing optimization resources,...
Drug loaded multi-layered gold nanorods exhibited synergistic photothermal and chemotherapy effects on tumors.
Galactose residues could be specifically recognized by the asialoglycoprotein receptor (ASGPR) which is highly exhibited on liver tissues. However, ASGPR has not been widely investigated different tumor cell lines except for hepatoma carcinoma cells, motivates us to investigate possibility of galactose serving as a board ligand. In this study, (Gal)-based probe conjugated with fluorescence dye MPA (Gal-MPA) was constructed evaluation affinities/targeted ability lines. vitro it indicated that...
This study investigated the effects of lysine addition (0 g/100g, 0.25 0.50 0.75 1.00 1.25 g/100g) on physiochemical properties a soy protein-wheat gluten mixture subjected to high-moisture extrusion. Extrudates were evaluated in terms color, degree texturization, textural properties, microstructure, water distribution, rheological protein solubility and secondary structure. The results showed that deepened color extrudates increased texturization (2.00–2.73) chewiness extrudates. Adding...
Two kinds of thermally responsive polymers P(FAA-NIPA-co-AAm-co-ODA) and P(FPA-NIPA-co-AAm-co-ODA) containing folate, isopropyl acrylamide octadecyl acrylate were fabricated through free radical random copolymerization for targeted drug delivery. Then the micelles formed in aqueous solution by self-assembly characterized terms particle size, lower critical temperature (LCST) a variety optical spectra. MTT assays demonstrated low cytotoxicity control micelle drug-loaded on A549 cells Bel 7402...
A series of N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives with NF-κB inducing kinase (NIK) inhibitory activity were obtained through structure-based drug design and synthetic chemistry. Among them, 4-(3-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-morpholinophenyl)-2-(thiazol-2-yl)but-3-yn-2-ol (12f) was identified as a highly potent NIK inhibitor, along satisfactory selectivity. The pharmacokinetics 12f its ability to inhibit interleukin 6 secretion in BEAS-2B cells better than...
Tocopherols and phytosterols are generally considered to be nutritionally beneficial, 3-Monochloropropane-1,2-diol esters (3-MCPD esters), glycidyl (GEs) trans fatty acids (TFAs) harmful. The high temperature deodorization step is when these harmful 3-MCPD esters, GEs TFAs generated. Knowing how conditions affect levels of substances essential for designing refining processes that will produce nutritious, quality edible oils. This study analyzed the changes components sunflower oil at...
Background kalirin RhoGEF kinase ( KALRN ) is mutated in a wide range of cancers. Nevertheless, the association between mutations and pathogenesis cancer remains unexplored. Identification biomarkers for immunotherapy response crucial because immunotherapies only show beneficial effects subset patients with cancer. Methods We explored correlation antitumor immunity 10 cohorts from The Cancer Genome Atlas program by bioinformatics approach. Moreover, we verified findings analysis vitro vivo...
Bombesin (BBN), an analog of gastrin‐releasing peptide (GRP), which the receptors are over‐expressed on various tumor cells, is able to bind GRP receptor specifically. In this study, a near‐infrared fluorescent dye (MPA) and polyethylene glycol (PEG) were conjugated BBN form BBN[7–14]–MPA BBN[7–14]–SA–PEG–MPA. The successful synthesis two probes was proved by characterization via sodium dodecylsulfate–polyacrylamide gel electrophoresis, infrared optical spectra. Cellular uptakes studies...
The unique properties of gold nanoclusters (Au NCs) enable them to be functionalized as fluorescent probes or pro-drugs for biomedical application. A facile approach was introduced synthesize nanoconjugates (Au–cRGD–MPA), which composed Au NCs, cyclic (Arg–Gly–Asp–DTyr–Lys) (cRGD) peptide and a near infrared (NIR) fluorescence dye (MPA). exhibited dual in the visible range NIR simultaneously. low cytotoxicity Au–cRGD–MPA demonstrated MCF-7 cell line U87 line. affinity investigations verified...
The human vascular endothelial growth factor receptor-2 (VEGFR-2) has been an attractive target for the inhibition of angiogenesis. In current study, we used a hybrid protocol virtual screening methods to retrieve new VEGFR-2 inhibitors from Zinc-Specs Database (441 574 compounds). included initial candidates by comparing 2D similarity five reported top active 13 X-ray crystallography structures, followed pharmacophore modeling on basis receptor-ligand interactions and further narrowing...
Conventional chemotherapy suffers from non-specificity, lack of aqueous solubility and multidrug resistance. Tumor-targeting nanotherapeutics exhibit unique advantages in the delivery drugs specifically into tumors. Here, folic acid (FA), methionine (Met) a near infrared (NIR) fluorescence probe (cypate, ICG derivative) were all bio-conjugated to succinyl-chitosan (SC) micelles. An anti-cancer drug (paclitaxel, PTX) was loaded hydrophobic cores formed FA–Met–SC–ICG derivative (FMSCI)...