A5074790299- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- COVID-19 epidemiological studies
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- Prostate Cancer Treatment and Research
- COVID-19 diagnosis using AI
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Gene Regulatory Network Analysis
- Pancreatic function and diabetes
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
- COVID-19 impact on air quality
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Urologic and reproductive health conditions
Oregon Health & Science University
1995-2025
Hebei Normal University
2025
China Pharmaceutical University
2020-2023
Abstract Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features solid tumorigenesis, wherein alterations immune non-immune stromal elements enable loss homeostasis during onset. The precise mechanisms by which cell states limit plasticity lost progression, remain largely unknown. Here we show that healthy pancreatic mesenchyme expresses the paracrine signaling molecule KITL, also known stem factor,...
The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is characterized by a limited infiltration tumor-specific T cells and anti-tumor cell activity. Extracellular factors in the PDAC TME have been widely reported to mediate immune suppression, but contribution from tumor-intrinsic not well understood. RNA-binding protein, HuR (ELAVL1), enriched negatively correlates with infiltration. In an immunocompetent Kras-p53-Cre (KPC) orthotopic model PDAC, we found that genetic...
Abstract Pevonedistat (TAK924) is a Nedd8-activating enzyme inhibitor with preclinical activity in non-Hodgkin lymphoma (NHL). This open-label, Phase I, multicenter, investigator-sponsored study enrolled patients relapsed/refractory (R/R) NHL and chronic lymphocytic leukemia (CLL). The primary objective was safety. given intravenously on days 1, 3, 5 of 21-day cycle for 8 cycles at five dose levels (15 to 50 mg/m 2 ); ibrutinib administered 420 or 560 mg orally daily continuously. Eighteen...
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) tumors contain chaotic vasculature that limits immune surveillance and promotes early events in the metastatic cascade. However, current antiangiogenic therapies have failed PDAC, thus, it remains important to uncover mechanisms by which cancer cells signal endothelial increase angiogenesis. Our lab has shown tumor-intrinsic RNA-binding protein HuR ( ELAVL1 ) plays an role re-shaping tumor microenvironment (TME) regulating stability...
<div>Abstract<p>Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features solid tumorigenesis, wherein alterations immune nonimmune stromal elements enable loss homeostasis during onset. The precise mechanisms by which cell states limit plasticity lost progression, remain largely unknown. In this study, we show that healthy pancreatic mesenchyme expresses the paracrine signaling molecule KITL,...
<p>Supplementary Figure S3: Stromal KITL promotes regulation of pancreas tissue architecture</p>
<p>Supplementary Figure S2: Kitl is expressed by healthy pancreatic mesenchyme and reduced upon activation to a CAF phenotype</p>
<p>Supplementary Figure S1: scRNA-seq reveals gene expression programs in PSCs and PSC-derived CAFs</p>
<p>Supplementary Figure S4: Stromal KITL promotes pancreas tissue homeostasis</p>
Background and Aims: Chronic pancreatitis (CP) is characterized by inflammation, fibrosis, acinar-to-ductal metaplasia (ADM). PIN1, known to drive oncogenic signaling cellular plasticity in cancer, has an unexplored role CP. This study investigates PIN1's expression function CP pathogenesis using human tissues mouse models. Methods: PIN1 was assessed tissue microarrays (TMAs) via immunohistochemistry (IHC) cyclic immunofluorescence (CyCIF). Acute chronic were induced wild-type (WT) knockout...
Abstract Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features solid tumorigenesis, wherein alterations immune non-immune stromal elements enable loss homeostasis during evolution. The precise mechanisms by which cell states limit plasticity lost progression, remain largely unknown. Here we show that healthy pancreatic mesenchyme expresses the paracrine signaling molecule KITL, also known stem factor,...
Abstract The earliest cats in human settlements China were not domestic ( Felis catus ), but native leopard Prionailurus bengalensis ). To trace when and how arrived East Asia, we analyzed 22 feline bones from 14 sites across spanning 5,000 years. Nuclear mitochondrial genomes revealed that began occupying anthropogenic scenes around 5,400 years ago last appeared 150 CE. Following several centuries’ gap of archeological remains, the first known cat (706–883 CE) was identified Shaanxi during...
Abstract Background Although COVID-19 has been well controlled in China, it is rapidly spreading outside the country and may have catastrophic results globally without implementation of necessary mitigation measures. Because outbreak made comprehensive profound impacts on world, an accurate prediction its epidemic trend significant. many studies predicted trend, most used early-stage data focused Chinese cases. Methods We first built models to predict daily numbers cumulative confirmed cases...
Intratumor heterogeneity (ITH) is associated with tumor development, prognosis, immune evasion and therapeutic effects. We proposed the Defining ITH based on EntRopy (DITHER) algorithm for evaluating ITH. first evaluated entropies of somatic mutation profiles copy number alteration (CNA) in a tumor, respectively, defined their average as level tumor. Using DITHER, we analyzed 33 cancer types from The Cancer Genome Atlas (TCGA) program. demonstrated that by DITHER had typical properties ITH,...
Abstract Neddylation is a sequential enzyme-based process which regulates the function of E3 Cullin-RING ligase (CRL) and thus degradation substrate proteins. Here we show that CD8 + T cells are direct target for therapeutically relevant anti-lymphoma activity pevonedistat, Nedd8-activating enzyme (NAE) inhibitor. Pevonedistat-treated patient-derived upregulated TNFα IFNγ exhibited enhanced cytotoxicity. Pevonedistat induced T-cell inflamed microenvironment delayed tumor progression in A20...
Abstract There is now increasing recognition of the important role androgen receptor (AR) in modulating immune function. To gain a comprehensive understanding effects AR activity on cancer immunity, we employed computational approach to profile 33 human tumor types using RNA-Seq datasets from The Cancer Genome Atlas. Our pan-cancer analysis revealed that genes most negatively correlated with across cancers are involved active system processes. Importantly, observed significant negative...
Background kalirin RhoGEF kinase ( KALRN ) is mutated in a wide range of cancers. Nevertheless, the association between mutations and pathogenesis cancer remains unexplored. Identification biomarkers for immunotherapy response crucial because immunotherapies only show beneficial effects subset patients with cancer. Methods We explored correlation antitumor immunity 10 cohorts from The Cancer Genome Atlas program by bioinformatics approach. Moreover, we verified findings analysis vitro vivo...
Abstract The COVID-19 virus has infected millions of people and resulted in hundreds thousands deaths worldwide. By using the logistic regression model, we identified novel critical factors associated with COVID19 cases, death, case fatality rates 154 countries 50 U.S. states. Among numerous risk, found that unitary state system was counter-intuitively positively increased cases deaths. Blood type B a protective factor for while blood A risk factor. prevalence HIV, influenza pneumonia,...
Alterations in the spliceosome pathway (SP) have been associated with diverse human cancers. In this study, we explored associations of SP activity various clinical features, anti-tumor immune signatures, tumor immunity-related genomic and molecular response to immunotherapies targeted therapies 29 cancer types from The Cancer Genome Atlas (TCGA) database. We showed that was an oncogenic signature, as evidenced by its hyperactivation invasive subtypes correlations unfavorable outcomes...
E1A binding protein p300 ( EP300 ) is mutated in diverse cancers. Nevertheless, a systematic investigation into the associations of mutations with genome instability and antitumor immunity pan-cancer remains lacking. Using datasets from The Cancer Genome Atlas, we analyzed correlations between immune response 11 cancer types. Compared to -wild-type cancers, -mutated cancers had significantly higher tumor mutation burden (TMB) 10 harbored much fraction microsatellite instable colon gastric...