A5015435831- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Retinal Diseases and Treatments
- Histone Deacetylase Inhibitors Research
- Ocular Oncology and Treatments
- Neurofibromatosis and Schwannoma Cases
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Chromatin Remodeling and Cancer
- Meningioma and schwannoma management
- Ubiquitin and proteasome pathways
- Radiation Therapy and Dosimetry
Children Cancer Hospital
2018-2024
Abstract Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M–mutant is new entity introduced to HGG in the latest WHO classification. In this study we evaluated presence of H3K27M mutation 105 tumor samples histologically classified into low-grade (LGG) (n = 45), 60). Samples were screened for histone H3.3 H3.1 variants examine its prevalence, impact, assess potential clinical value limited resource...
Aggresomes are inclusion bodies for misfolded/aggregated proteins. Despite the role of proteins in neurological disorders, their cancer pathogenesis is poorly defined. In current study we aimed to investigate whether aggresomes-positivity could be used improve disease subclassification and prognosis prediction pediatric medulloblastoma. Ninety three medulloblastoma tumor samples were retrospectively stratified into molecular subgroups; WNT, SHH non-WNT/non-SHH, using immunohistochemistry...
Protein misfolding and aggregation result in proteotoxic stress underlie the pathogenesis of many diseases. To overcome proteotoxicity, cells compartmentalize misfolded aggregated proteins different inclusion bodies. The aggresome is a paranuclear body that functions as storage compartment for proteins. Choroid plexus tumors (CPTs) are rare neoplasms comprised three pathological subgroups. underlying mechanisms their remain unclear. This study aims to elucidate prognostic role biological...
Abstract Background: Pediatric gliomas comprise a clinically, histologically, and molecularly heterogeneous group of central nervous system tumors. The survival children with influenced by histologic subtype, age, extent resection. Tumor grade emerged as the most determinant except in young age groups. aim this study was to evaluate role multidisciplinary therapeutic approach including surgery chemotherapy, their impact on outcome pediatric patients low-grade glioma (LGG). Procedure: Study...
Abstract Purpose High-grade gliomas (HGG) in infants and very young children (less than 3 to 5 years old) pose significant challenges due the limited scientific literature available high risks associated with treatments. This study aims investigate characteristics, treatment, outcomes of this cohort. Methods A retrospective cohort was conducted from 2007 2022 at Children’s Cancer Hospital, Egypt (CCHE-57357). Cases included aged < old pathologically confirmed CNS glioma grades III-IV....