A5079488421- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Medical Imaging Techniques and Applications
- Cancer Research and Treatments
- Vascular Tumors and Angiosarcomas
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Cardiac Structural Anomalies and Repair
- Inflammatory Biomarkers in Disease Prognosis
- Protein Degradation and Inhibitors
- Aortic Thrombus and Embolism
- Parvovirus B19 Infection Studies
- Chromatin Remodeling and Cancer
- Urologic and reproductive health conditions
- Empathy and Medical Education
- Pericarditis and Cardiac Tamponade
- Cardiac tumors and thrombi
Ministry of Health of the Russian Federation
2018-2024
Research Medical Center
2024
Russian Cancer Research Center NN Blokhin
2017
Russian Scientific Center of Radiology and Surgical Technologies
2014
Federal Almazov North-West Medical Research Centre
2009
В статье представлены результаты голосования I Cанкт-Петербургского международного консенсуса по диагностике и лечению рака молочной железы «Белые ночи 2024», посвященного наиболее актуальным спорным вопросам диагностики, хирургической тактики, лучевой терапии системного лечения данной категории пациентов. Под председательством член-корреспондента РАН, профессора Владимира Федоровича Семиглазова в международном консенсусе приняли участие 38 экспертов области диагностики (РМЖ),...
Восемьдесят лет назад была снята 872-дневная блокада Ленинграда. Сегодня невозможно найти среди жителей современного Санкт-Петербурга, тех кто не знает об ужасах войны и героизме блокадного Ленинграда, которые победили, пережив голод, бомбежки, смерть близких. Вместе с тем, архив лаборатории патологической анатомии Института ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России, который ведется со дня его основания в 1926 г., хранит уникальные свидетельства ежедневного подвига врачей...
The aim of the study is to evaluate prognostic and predictive capabilities tumorinfiltrating lymphocytes in breast cancer (BC); value T-cell (CD8+, CD3+) lymphocyte infiltration tumor level T-regulatory (CD4+) lymphocytes; expression proteins Forkhead Box Protein 3, check-point PD-1, PDL1. Materials methods. content tumor-infiltrating their quantitative ratio correlation with regulatory genes were assessed. Archival material was used work. included archival data from registry 1240 patients...
Background. Dual anti-HER2-targeted therapy in breast cancer (BC) significantly increased the rate of pathological complete response (pCR) compared to single blockade when added chemotherapy. However, limited data exist on long-term impact survival additional increase pCR. Aim. To improve recommendations regarding HER2-targeted agents and chemotherapy neoadjuvant treatment BC. Materials methods. N.N. Petrov National Medical Research Oncology Center, Ministry Health Russia took participation...
Интимальная саркома – очень редкая злокачественная мезенхимальная опухоль, возникающая в крупных кровеносных сосудах системного и легочного кровообращения, а также сердце. Прогноз при интимальной саркоме обычно неблагоприятный, причем на него оказывает большое влияние выбор тактики лечения пользу хирургического вмешательства. Статья представляет собой анализ двух клинических случаев саркомы сердца, обзор литературы, обсуждение возможных ошибок диагностике этого редкого заболевания.
Tumor cell proliferation and angiogenesis are essential factors for tumor growth, progression, metastasis. Objective: to assess the relationship between values of proliferative activity morphometric parameters intratumoral microvessels in metastatic localized carcinomas kidney. Materials methods. Surgical specimens taken from 54 patients (32 men 22 women) aged 26 69 years (mean age 55 ± 1.5 years) with verified diagnosis clear-cell renal carcinoma (RCC) were studied. Conclusion....
The semi-quantitative histologic and immunohistochemical analyses were carried out on the biopsy autopsy samples of right atrium, interatrial septum left ventricle 110 patients. antibodies against calcineurin, natriuretic peptide, prealbumin (transthyretin), λ- κ-light chains, АА amyloid, Ki-67-antigen, VP1-antigen enterovirus, herpes simplex virus, cytomegalovirus, LMP- antigen Epstein-Barr adenovirus, parvovirus B19 used. All cases with persistent atrial fibrillation are characterized by...
Background. Breast cancer is a heterogeneous disease with variety of phenotypic forms. Triple-negative breast (TNBC) one the most aggressive subtypes characterized by high sensitivity to chemotherapy and early recurrence. Due lack efficiency standard therapeutic approaches, it appears extremely important search for new regimens neoadjuvant polychemotherapy (NAPCT). Objective: assess different NAPCT treatment stages T1N1–3 T2–4N0–3 locally advanced TNBC compare eribulin paclitaxel in TNBC....
According publications' data, the range of diagnostic sensitivity cytological analysis exudates makes up to 64%-96%. In case emergency intra-operational diagnostic, a necessity occurs implement additional techniques. One them is fluorescent immune cytochemical with monoclonal antibodies BER-EP4, conjugated fluorochrome FITC. The mentioned demonstrates high specificity and under differential metastatic reactive exudates.
Objective: to study the breast cancer phenotype (ER/PR, FOXA1, HER2, Ki67) and dynamics of changes in these markers tumour before after neoadjuvant chemotherapy (NAT), compare them with metastases regional lymph nodes (LN). Materials methods. The subject was a group patients carcinomas receiving NAT according TAC TC regimens, who had LUs course treatment (urN1,2,3). Results. Patients were divided into three groups. first (n = 11, primary NAT). conversion hormone receptor expression both...
Immunohistochemical study of breast cancer has been practiced for several decades; however, the standardization this process not yet achieved, despite substantial advances in methodology. The paper presents practical guidelines and standards testing carcinomas, which can be used as day-to-day control work an immunohistochemistry laboratory. It considers concept external quality immunohistochemical detection estrogen (ER) progesterone (PR) receptors, well problems harmonization analysis by...
Small cell carcinoma of the prostate is a rare and very aggressive tumor. Primary emphasis laid on morphological immunohistochemical characteristics this type tumor, clinical presentations disease, performed treatment, its response. Three cases small with their further discussion are described.
The authors provide the proceedings of 2005 First International Society Urological Pathology Consensus Conference and basic provisions that differ modified Gleason grading system from its original interpretation. In particular, we should do away with grade 1 (or + = 2) while assessing needle biopsy specimens. Contrary to recommendations by himself, conference decided apply stringent criteria for using grades 3 4. This is due fact these are special prognostic value so it important have clear...
The article provides an overview of the main changes in current (2020) WHO classification soft tissue tumors, as well selected updates that have occurred since release classification.В статье представлен обзор основных изменений в текущей (2020 г.) классификации ВОЗ опухолей мягких тканей, а также избранных обновлений, произошедших уже после выхода классификации.
Introduction. It is essential to accurately identify HER2-amplified tumors for effective classification and treatment of breast cancer patients. The most precise method detecting HER2 gene amplification fluorescence in situ hybridization (FISH) testing. When tumor status uncertain IHC analysis, FISH testing becomes necessary proper into the category triple-positive carcinomas. Data on biology such their response therapy are limited inconsistent, which makes this topic an interesting area...