A5049326120- Visual perception and processing mechanisms
- Reading and Literacy Development
- Neural and Behavioral Psychology Studies
- Cognitive and developmental aspects of mathematical skills
- Face Recognition and Perception
- Spatial Neglect and Hemispheric Dysfunction
- EEG and Brain-Computer Interfaces
- Tactile and Sensory Interactions
- Color perception and design
- Neural dynamics and brain function
- Gaze Tracking and Assistive Technology
- Protein Tyrosine Phosphatases
- Multiple Myeloma Research and Treatments
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Glycosylation and Glycoproteins Research
- Traumatic Brain Injury Research
- Thyroid Cancer Diagnosis and Treatment
- Multisensory perception and integration
- Peptidase Inhibition and Analysis
- Tracheal and airway disorders
- Logic, Reasoning, and Knowledge
- Currency Recognition and Detection
- Galectins and Cancer Biology
- Ophthalmology and Visual Impairment Studies
Fondazione Santa Lucia
2014-2024
Sapienza University of Rome
2015-2024
Enrico Fermi Center for Study and Research
2023
Scuola Internazionale Superiore di Studi Avanzati
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2023
University of Bologna
2023
University of Rome Tor Vergata
2023
Candiolo Cancer Institute
2008-2014
New York University
2003-2010
University of Turin
2008-2010
Germline mutations of the tumour suppressor gene BRCA1 are involved in predisposition and development breast cancer account for 20–45% all hereditary cases. There is an increasing evidence that these tumours characterised by a specific phenotype pattern expression. We have hypothesised differences chemosensitivity might parallel molecular heterogeneity sporadic tumours. To this end, we investigated BRCA1-defective HCC1937 cell line, BRCA1-competent MCF-7 (hormone-sensitive) MDA-MB231...
Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence situ hybridization probes, we show complex karyotypic abnormalities of the or L-myc 19 20 MM cell lines approximately 50% advanced primary tumors. These include unusual translocations insertions that often juxtapose myc with IgH IgL locus. For two tumors, some tumor cells contain a abnormality locus, whereas other do not, indicating this occurs as late event....
Do we identify an object as a whole or by its parts? This simple question has been surprisingly hard to answer. It suggested that faces are recognized wholes and words parts. Here answer the applying test for crowding. In crowding, target is harder in presence of nearby flankers. Previous work described crowding between objects. We show also occurs parts object. Such internal severely impairs perception, identification, fMRI face-area activation. apply diagnostic word face, find critical...
We tested the hypothesis that crowding effects are responsible for reading slowness characteristic of developmental dyslexia. A total twenty-nine Italian dyslexics and thirty-three age-matched controls participated in various parts study. In Experiment 1, we measured contrast thresholds identifying letters words as a function stimulus duration. Thresholds were higher than (at limited time exposure) but not single letters. Adding noise to stimuli produced comparable controls. At long exposure...
Abstract Vocal reaction times (RTs) in naming 3- to 8-letter words were measured proficient and dyslexic readers (Study 1). In readers, RTs independent of word length up 5-letter words, indicating parallel processing. the 5- range, increased linearly, sequential Reading experience was associated with both faster discrimination individual elements processing increasingly large parts. dyslexics, linearly increasing reliance on decoding. Individual analysis indicated 2 profiles (Types A B)....
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear involved in such cellular processes as adipogenesis, inflammation, atherosclerosis, cell cycle control, apoptosis, and carcinogenesis. PPARγ gene mutations have been found 4 of 55 sporadic colon cancers, chimeric PAX8-PPARγ1 frequently generates chromosomal translocation thyroid follicular carcinomas, implicating tumor suppression. We investigated whether the growth regulation normal cells. no exons 3 5 human carcinoma lines...
The effect of age on pain sensitivity is unclear. Some studies suggest a loss perception with age, whereas other indicate either no change or an increase in age. present study assessed perceived intensities six levels painful contact thermal stimuli (43 °C, 45 47 48 49 and 51 °C). Magnitude estimation procedures were used, participants instructed to provide separate ratings for the sensory intensity unpleasantness (affective intensity) during sessions. Middle-age adults showed lowest...
Abstract The pathogenesis of multiple myeloma (MM) is thought to involve at least two pathways, which generate hyperdiploid (HRD) or nonhyperdiploid (NHRD) tumors, respectively. Apart from chromosome content, the pathways are distinguished by five primary immunoglobulin heavy chain ( IGH ) rearrangements (4p16, FGFR3 , and MMSET ; 6p21, CCND3 11q13, CCND1 16q23, MAF 20q12, MAFB that present mainly in NHRD tumors. To determine prevalence structures IG light chain, MYC genomic MM, we have done...
Abstract We compared reading words and pseudo-words presented in single displays (as typical of psycholinguistic research) with stimuli multiple real-life conditions clinical testing) under controlled conditions. Italian sixth-grade children without a deficit showed an advantage times for over displays. This finding was partly ascribed to the capacity overlap non-decisional component response, effect present control readers as well dyslexia. Furthermore, there were several indications data...
We previously reported that galectin-1 gene expression increases up to 100-fold in oncogene-transformed rat thyroid cells compared with their normal counterparts and the relative mRNA levels correlate degree of malignancy. In present study we investigated whether is differentially expressed human neoplasms, which range from well-differentiated tumors undifferentiated anaplastic carcinomas. analyzed 74 specimens neoplastic, hyperproliferative tissues several tumor cell lines. Galectin-1...
<ns4:p>Crowding is a major limitation of visual perception. Because crowding, simple object, like letter, can only be recognized if clutter certain <ns4:italic>critical spacing </ns4:italic>away. Crowding weakly associated with acuity. The critical crowding lowest in the normal fovea, and grows increasing eccentricity peripheral vision. Foveal more prominent patient groups, including those strabismic amblyopia apperceptive agnosia. may lessen age during childhood as reading speed increases....
The "Sign-tracker/Goal-tracker" (ST/GT) is an animal model of individual differences in learning and motivational processes attributable to distinctive conditioned responses environmental cues. While GT rats value the reward-predictive cue as a mere predictor, ST attribute it with incentive salience, engaging aberrant reward-seeking behaviors that mirror those impulse control disorders. Given its potential clinical value, present study aimed map such onto humans investigated resting state...