A5055214550- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- Cancer-related gene regulation
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- RNA and protein synthesis mechanisms
- HVDC Systems and Fault Protection
- Prostate Cancer Diagnosis and Treatment
Zhejiang University
2024
First Affiliated Hospital Zhejiang University
2022-2024
Background: Bladder cancer (BC) represents a common malignancy and is characterized by high heterogeneity complex biological behaviors, which pose substantial challenges to its effective treatment. Mounting evidence highlights the pivotal roles of ribonucleic acid (RNA) modifications, particularly N6-methyladenosine, alongside others such as 1-methyladenosine, 5-methylcytosine, N4-acetylcytidine, 7-methylguanosine, in regulation proliferation, migration, drug resistance, immune evasion BC...
FTO, as an m6A mRNA demethylase, is involved in various cancers. However, the role of FTO clear cell renal carcinoma (ccRCC) remains unclear. In present study, we discovered upregulated ccRCC. Functionally, knockdown significantly impairs proliferation and migration ability ccRCC cells. Mechanistically, our data suggest promotes through preventing degradation PDK1 induced by YTHDF2 m6A-dependent mechanism. Overall, results identify protumorigenic m6A/YTHDF2/PDK1 pathway, which could be a...
Abstract R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and displaced single-stranded DNA, that frequently form during transcription may be attributed to genomic stability gene expression regulation. It was recently discovered RNA modification contributes maintain the of such as N6-methyladenosine (m 6 A). Yet, m A-modified in regulating remains poorly understood. Here, we demonstrated insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs)...
R-loops are critical structures that play pivotal roles in regulating genomic stability and modulating gene expression. This study investigates the interactions between 5-methylcytosine (m
To assess the clinical utility of PCA3 in diagnostic accuracy, correlation between and biopsy or pathological characteristics performance to reduce unnecessary biopsies Chinese population.